Hypercholesterolemia, a pivotal public health concern, propels the collaborative international project CASH (Chromophores Actifs en Santé Humaine) to explore natural alternatives to statins for blood cholesterol level reduction, aiming to prevent cardiovascular risks. This project, cofounded by Walloon Region through the WAGRALIM Competitiveness Cluster, is a partnerships between the University of Liège, the University of Louvain-La-Neuve, the University of Lille, Tilman sa and Biores sa (two Wallonia-based compagnies). Spirulina, a blue-green alga of the Cyanophyceae family, is celebrated for its exceptional nutritional properties and well-established antioxidant, antidiabetic, and anti-inflammatory activities [1, 2]. Spirulina contains the phycocyanin, a chromoprotein used as natural blue pigment in food. The CASH project unfolds through diverse tasks ranging from: (i) assessing the bioactive potential of peptides from spirulina proteins through an in silico approach, (ii) developing bioactive spirulina protein hydrolysates, (iii) evaluating the hypocholesterolemic and antioxidant activities before and after simulated in vitro static INFOGEST gastrointestinal digestion [3, 4], and (iv) identifying peptides and chromopeptides responsible for the studied bioactivities through a peptidomic approach. The project led to the identification of fractions obtained by gel filtration of phycocyanins hydrolysates with high antioxidant activity. This innovative study promises to redefine preventive approaches against cardiovascular diseases by harnessing the bioactive potential of spirulina peptides, paving the way for natural and sustainable solutions to enhance cardiovascular human health. 1. Abreu AP, Martins R, Nunes J (2023) Emerging Applications of Chlorella sp. and Spirulina (Arthrospira) sp. Bioengineering 10:955. doi: 10.3390/bioengineering10080955 2. Gentscheva G, Nikolova K, Panayotova V, et al (2023) Application of Arthrospira platensis for Medicinal Purposes and the Food Industry: A Review of the Literature. Life 13:845. doi: 10.3390/life13030845 3. Brodkorb A, Egger L, Alminger M, et al (2019) INFOGEST static in vitro simulation of gastrointestinal food digestion. Nat Protoc 14:991–1014. doi: 10.1038/s41596-018-0119-1 4. Atallah N, Deracinois B, Boulier A, et al (2020) In Vitro Assessment of the Impact of Industrial Processes on the Gastrointestinal Digestion of Milk Protein Matrices Using the INFOGEST Protocol. Foods 9:1580. doi: 10.3390/foods9111580