Environmental risk factors in puppies and kittens for developing chronic disorders in adulthood: A call for research on developmental programming - Biologie de la reproduction, environnement, épigénétique et développement Accéder directement au contenu
Article Dans Une Revue Frontiers in Veterinary Science Année : 2022

Environmental risk factors in puppies and kittens for developing chronic disorders in adulthood: A call for research on developmental programming

Résumé

Many dogs and cats are affected by chronic diseases that significantly impact their health and welfare and relationships with humans. Some of these diseases can be challenging to treat, and a better understanding of early-life risk factors for diseases occurring in adulthood is key to improving preventive veterinary care and husbandry practices. This article reviews early-life risk factors for obesity and chronic enteropathy, and for chronic behavioral problems, which can also be intractable with life-changing consequences. Aspects of early life in puppies and kittens that can impact the risk of adult disorders include maternal nutrition, establishment of the gut microbiome, maternal behavior, weaning, nutrition during growth, growth rate, socialization with conspecifics and humans, rehoming and neutering. Despite evidence in some species that the disorders reviewed here reflect the developmental origins of health and disease (DOHaD), developmental programming has rarely been studied in dogs and cats. Priorities and strategies to increase knowledge of early-life risk factors and DOHaD in dogs and cats are discussed. Critical windows of development are proposed: preconception, gestation, the suckling period, early growth pre-neutering or pre-puberty, and growth post-neutering or post-puberty to adult size, the durations of which depend upon species and breed. Challenges to DOHaD research in these species include a large number of breeds with wide genetic and phenotypic variability, and the existence of many mixed-breed individuals. Moreover, difficulties in conducting prospective lifelong cohort studies are exacerbated by discontinuity in pet husbandry between breeders and subsequent owners, and by the dispersed nature of pet ownership.

Mots clés

Fichier principal
Vignette du fichier
Gaillard et al. Environmental risk factors in puppies and kittens for developing chronic disorders in adulthood. Frontiers in Vet Sci. 2022.pdf (1.8 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03912284 , version 1 (23-12-2022)

Licence

Paternité

Identifiants

Citer

Sylvie Chastant, Gary England, Oliver Forman, Alexander German, Jan Suchodolski, et al.. Environmental risk factors in puppies and kittens for developing chronic disorders in adulthood: A call for research on developmental programming. Frontiers in Veterinary Science, 2022, 9, ⟨10.3389/fvets.2022.944821⟩. ⟨hal-03912284⟩
56 Consultations
63 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More