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Role of Polycomb in the control of transposable elements

Abstract : It has been generally accepted that H3K9me2-3/DNA methylation and H3K27me3 silent heterochromatin marks are found in mutually exclusive genomic regions and display distinct properties. This view is challenged by recent observations of transposable elements marked by H3K27me3. We hypothesize an ancestral association of H3K27me3 with silencing of transposable elements. As multicellular eukaryotes evolved, H3K27me3 became associated with gene silencing, while H3K9/DNA methylation became dedicated to silencing transposable elements.
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https://hal.archives-ouvertes.fr/hal-03372798
Contributor : Sandra Duharcourt Connect in order to contact the contributor
Submitted on : Monday, October 25, 2021 - 11:49:29 AM
Last modification on : Thursday, January 27, 2022 - 3:41:00 AM

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Angélique Déléris, Frédéric Berger, Sandra Duharcourt. Role of Polycomb in the control of transposable elements. Trends in Genetics, Elsevier, 2021, 37 (10), pp.882-889. ⟨10.1016/j.tig.2021.06.003⟩. ⟨hal-03372798⟩

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