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A scaffold lncRNA shapes the mitosis to meiosis switch

Abstract : Long non-coding RNAs (lncRNAs) contribute to the regulation of gene expression in response to intra-or extracellular signals but the underlying molecular mechanisms remain largely unexplored. Here, we identify an uncharacterized lncRNA as a central player in shaping the meiotic gene expression program in fission yeast. We report that this regulatory RNA, termed mamRNA, scaffolds the antagonistic RNA-binding proteins Mmi1 and Mei2 to ensure their reciprocal inhibition and fine tune meiotic mRNA degradation during mitotic growth. Mechanistically, mamRNA allows Mmi1 to target Mei2 for ubiquitin-mediated downregulation, and conversely enables accumulating Mei2 to impede Mmi1 activity, thereby reinforcing the mitosis to meiosis switch. These regulations also occur within a unique Mmi1containing nuclear body, positioning mamRNA as a spatially-confined sensor of Mei2 levels. Our results thus provide a mechanistic basis for the mutual control of gametogenesis effectors and further expand our vision of the regulatory potential of lncRNAs.
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https://hal.archives-ouvertes.fr/hal-03435964
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Submitted on : Friday, November 19, 2021 - 9:21:19 AM
Last modification on : Tuesday, January 4, 2022 - 6:38:36 AM

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Vedrana Andric, Alicia Nevers, Ditipriya Hazra, Sylvie Auxilien, Alexandra Menant, et al.. A scaffold lncRNA shapes the mitosis to meiosis switch. Nature Communications, Nature Publishing Group, 2021, 12 (1), ⟨10.1038/s41467-021-21032-7⟩. ⟨hal-03435964⟩

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