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Article Dans Une Revue Journal of Chromatography A Année : 2020

Scout-multiple reaction monitoring: A liquid chromatography tandem mass spectrometry approach for multi-residue pesticide analysis without time scheduling

Résumé

In this work, an innovative method is described for multi-residue pesticide analysis by liquid chromatography coupled to targeted mass spectrometry, called "Scout-MRM, this new acquisition mode relies on the monitoring by either endogenous or spiked Scout compounds, hence fully releasing the monitoring of target molecules from time scheduling. As a proof of concept, a Scout-MRM method was built where 5 transitions groups tracking a total of 191 pesticides where successively triggered under the control of 5 spiked-in deuterated pesticides. As expected from its retention time independency, Scout-MRM demonstrates strong detection robustness towards modifications of gradient parameters, as well as easy method transfer between distinct analytical platforms with nearly 100% recovery after a single run. Finally, Scout-MRM was used for the multi-residue screening and quantification of pesticides in real surface water samples, by applying an external calibration procedure and comparing it with classical scheduled reaction monitoring methods.
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hal-02771252 , version 1 (20-05-2022)

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Paternité - Pas d'utilisation commerciale

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Arnaud Salvador, Romain Carrière, Sophie Ayciriex, Christelle Margoum, Yves Leblanc, et al.. Scout-multiple reaction monitoring: A liquid chromatography tandem mass spectrometry approach for multi-residue pesticide analysis without time scheduling. Journal of Chromatography A, 2020, 1621, pp.461046. ⟨10.1016/j.chroma.2020.461046⟩. ⟨hal-02771252⟩
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