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FOOTNOTES We would like to thank several people: D.J. Mangelsdorf (Howard Hughes Medical Institute, Dallas, TX) for providing the LXR?/? knockout mice, N. Aguilera and A. Couzon for taking care of our mice at the PBES (ENS Lyon, France), D. Jeantet for the genotyping, F. Flamant and L. Canaple for critical reading of the manuscript. This work was supported by SIGNATOR ANR-06, Crescendo Contract LSHM-CT-2005-018652, Cascade, Contract FOOD-CT-2004-506319, the Fondation pour la Recherche Médicale Grant INE2000-407031/1 and the Fondation BNP-Paribas, pp.2159-2170, 2006. ,