GENEALOGIES OF TWO LINKED NEUTRAL LOCI AFTER A SELECTIVE SWEEP IN A LARGE POPULATION OF VARYING SIZE - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Accéder directement au contenu
Pré-Publication, Document De Travail Année : 2015

GENEALOGIES OF TWO LINKED NEUTRAL LOCI AFTER A SELECTIVE SWEEP IN A LARGE POPULATION OF VARYING SIZE

Résumé

We study the impact of a hard selective sweep on the genealogy of partially linked neu-tral loci in the vicinity of the positively selected allele. We consider a sexual population of varying size and, focusing on two neighboring loci, derive an approximate formula for the neutral geneal-ogy of a sample of individuals taken at the end of the sweep. We prove that the stochasticity of the population size has a major impact on this genealogy and apply our results to the derivation of the linkage disequilibrium between neutral loci, a statistic which is frequently used to detect recent se-lection on genetic data. Furthermore, we provide a deeper insight into the dynamics of the mutant and wild type population during the different stages of a selective sweep.
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Dates et versions

hal-01116232 , version 1 (12-02-2015)
hal-01116232 , version 2 (17-02-2015)
hal-01116232 , version 3 (06-05-2016)

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Brink-Spalink Rebekka, Charline Smadi. GENEALOGIES OF TWO LINKED NEUTRAL LOCI AFTER A SELECTIVE SWEEP IN A LARGE POPULATION OF VARYING SIZE. 2015. ⟨hal-01116232v1⟩
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