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Transient receptor potential canonical 3 (trpc3) Figure 4: MBH TRPC3 channels ar e r equir ed for brain glucose det ect ion. A. Food int ake in response t o int racerebrovent ricular ( I CV) infusion of glucose or sucrose ( lat eral vent ricule, 0.125 µg in 2 µl infused in 5 m in) in 18h fast ed/ TRPC3 WT ( Sucrose: n= 6; Glucose: n= 5) and TRPC3 KO m ice ( Sucrose: n= 6; Glucose: n= 6) . B. Food intake in response t o int raper it oneal infusion of glucose ( 2 g kg) or NaCl ( 0.9 % ) in 18h, UCP2 Regulates Mitochondrial Fission and Ventromedial Nucleus Control of Glucose Responsiveness. Cell ce document : Chrétien, 2017. ,
, delt a insulin secret ion vs. t = 0; C right below) in response t o an int racarot id glucose inj ect ion ( 25 m g kg) in TRPC3 WT ( n= 8) and KO ( n= 13) m ice. D. Experim ent al prot ocol ( D left ) , blood glucose ( D right above) or plasm a insulin ( delt a insulin secret ion vs. t = 08) . * : p< 0.05, * * p < 0.01 vs. WT or Vehicle, Two/ way ANOVA + bonfer oni post / hoc t est, Experim ent al prot ocol ( C left ) , blood glucose ( C right t op) and plasm a insulin
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