Gut metagenome in European women with normal, impaired and diabetic glucose control, Nature, vol.35, issue.7452, pp.99-103, 2013. ,
DOI : 10.1111/j.1574-6976.2010.00251.x
Metabolome 2.0: quantitative genetics and network biology of metabolic phenotypes, Molecular BioSystems, vol.8, issue.10, pp.2494-502, 2012. ,
DOI : 10.1039/c2mb25049g
Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity, Diabetes, vol.63, issue.6, pp.2158-71, 2014. ,
DOI : 10.2337/db13-0949
Living with water stress: evolution of osmolyte systems, Science, vol.217, issue.4566, pp.1214-1236, 1982. ,
DOI : 10.1126/science.7112124
Finding the missing heritability of complex diseases, Nature, vol.41, issue.7265, pp.747-53, 2009. ,
DOI : 10.1016/j.tig.2007.12.007
Chemical Chaperones Reduce ER Stress and Restore Glucose Homeostasis in a Mouse Model of Type 2 Diabetes, Science, vol.313, issue.5790, pp.1137-1177, 2006. ,
DOI : 10.1126/science.1128294
Chemical chaperones assist intracellular folding to buffer mutational variations, Nature Chemical Biology, vol.170, issue.3, pp.238-283, 2012. ,
DOI : 10.1006/jmbi.1998.2395
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527004
Microscopic insights into the protein-stabilizing effect of trimethylamine N-oxide (TMAO), Proceedings of the National Academy of Sciences, vol.134, issue.15, pp.8476-81, 2014. ,
DOI : 10.1063/1.3580776
Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat, Nature Genetics, vol.51, issue.1, pp.38-43, 1996. ,
DOI : 10.1038/ng0196-38
URL : https://hal.archives-ouvertes.fr/hal-00399332
Defects in Insulin Secretion and Action in the Pathogenesis of Type 2 Diabetes Mellitus, Current Diabetes Reports, vol.42, issue.Suppl 2, pp.184-91, 2010. ,
DOI : 10.1172/JCI39721
Pathophysiological, Genetic and Gene Expression Features of a Novel Rodent Model of the Cardio-Metabolic Syndrome, PLoS ONE, vol.21, issue.8, p.2962, 2008. ,
DOI : 10.1371/journal.pone.0002962.s002
New genetic loci link adipose and insulin biology to body fat distribution, Nature, vol.9, issue.7538, pp.187-96, 2015. ,
DOI : 10.1038/nmeth.2212
URL : https://hal.archives-ouvertes.fr/hal-01132692
Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice, Science, vol.59, issue.12, p.1241214, 2013. ,
DOI : 10.2337/db10-0253
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829625
A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk, Nature, vol.447, issue.7314, pp.460-464, 2010. ,
DOI : 10.1038/nature09386
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657719
Cytokine-Induced ??-Cell Death Is Independent of Endoplasmic Reticulum Stress Signaling, Diabetes, vol.57, issue.11, pp.3034-3078, 2008. ,
DOI : 10.2337/db07-1802
Age and Microenvironment Outweigh Genetic Influence on the Zucker Rat Microbiome, PLoS ONE, vol.18, issue.5, p.100916, 2014. ,
DOI : 10.1371/journal.pone.0100916.s022
URL : http://doi.org/10.1371/journal.pone.0100916
Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models, Nature Genetics, vol.75, issue.5, pp.666-72, 2007. ,
DOI : 10.1042/bj1180047
750 MHz 1H and 1H-13C NMR Spectroscopy of Human Blood Plasma, Analytical Chemistry, vol.67, issue.5, pp.793-811, 1995. ,
DOI : 10.1021/ac00101a004
An NMR-based metabonomic approach to investigate the biochemical consequences of genetic strain differences: application to the C57BL10J and Alpk:ApfCD mouse, FEBS Letters, vol.32, issue.3, pp.169-74, 2000. ,
DOI : 10.2329/perio.32.Supplement1_117
Metabotyping of Caenorhabditis elegans reveals latent phenotypes, Proceedings of the National Academy of Sciences, vol.16, issue.1, pp.19808-19820, 2007. ,
DOI : 10.1002/cem.695
URL : https://hal.archives-ouvertes.fr/hal-00294039
Urinary metabolic signatures of human adiposity, Science Translational Medicine, vol.308, issue.5728, pp.285-62, 2015. ,
DOI : 10.1126/science.1110591
Metabolite profiles and the risk of developing diabetes, Nature Medicine, vol.110, issue.4, pp.448-53, 2011. ,
DOI : 10.1007/BF00280883
Genetic Defects in Human Pericentrin Are Associated With Severe Insulin Resistance and Diabetes, Diabetes, vol.60, issue.3, pp.925-960, 2011. ,
DOI : 10.2337/db10-1334
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046854
LIGHT (TNFSF14) inhibits adipose differentiation without affecting adipocyte metabolism, International Journal of Obesity, vol.155, issue.2, pp.208-224, 2011. ,
DOI : 10.1016/j.febslet.2008.09.012
URL : http://www.nature.com/ijo/journal/v35/n2/pdf/ijo2010126a.pdf
Untargeted Metabolome Quantitative Trait Locus Mapping Associates Variation in Urine Glycerate to Mutant Glycerate Kinase, Journal of Proteome Research, vol.11, issue.2, pp.631-673, 2012. ,
DOI : 10.1021/pr200566t
URL : https://hal.archives-ouvertes.fr/hal-00699625
Glucose-Dependent Insulinotropic Polypeptide Enhances Adipocyte Development and Glucose Uptake in Part Through Akt Activation, Gastroenterology, vol.133, issue.6, pp.1796-805, 2007. ,
DOI : 10.1053/j.gastro.2007.09.005
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185546
H NMR-Based Metabolic Profiles, Analytical Chemistry, vol.87, issue.8, pp.4377-84, 2015. ,
DOI : 10.1021/acs.analchem.5b00145
Contrasting genetic architectures in different mouse reference populations used for studying complex traits, Genome Research, vol.25, issue.6, pp.775-91, 2015. ,
DOI : 10.1101/gr.187450.114
URL : http://genome.cshlp.org/content/25/6/775.full.pdf
An atlas of genetic influences on human blood metabolites, Nature Genetics, vol.32, issue.6, pp.543-50, 2014. ,
DOI : 10.1093/ije/dyg070
Genome-wide association study identifies multiple loci influencing human serum metabolite levels, Nature Genetics, vol.115, issue.3, pp.269-76, 2012. ,
DOI : 10.1093/bioinformatics/btm443
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605033
A Genome-Wide Metabolic QTL Analysis in Europeans Implicates Two Loci Shaped by Recent Positive Selection, PLoS Genetics, vol.1, issue.9, p.1002270, 2011. ,
DOI : 10.1371/journal.pgen.1002270.s010
A genome-wide perspective of genetic variation in human metabolism, Nature Genetics, vol.78, issue.2, pp.137-178, 2010. ,
DOI : 10.1038/ng.507
A genome-wide association study of metabolic traits in human urine, Nature Genetics, vol.244, issue.6, pp.565-574, 2011. ,
DOI : 10.1086/519795
Mapping Pathways and Phenotypes by Systematic Gene Overexpression, Molecular Cell, vol.21, issue.3, pp.319-349, 2006. ,
DOI : 10.1016/j.molcel.2005.12.011
URL : http://doi.org/10.1016/j.molcel.2005.12.011
The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans, Science, vol.55, issue.4, pp.648-60, 2015. ,
DOI : 10.1016/j.biopsych.2003.10.013
Decreased myo-inositol to chiro-inositol (M/C) ratios and increased M/C epimerase activity in PCOS theca cells demonstrate increased insulin sensitivity compared to controls, Endocrine Journal, vol.61, issue.2, pp.111-118, 2014. ,
DOI : 10.1507/endocrj.EJ13-0423
In vivo chiro-inositol metabolism in the rat: a defect in chiro-inositol synthesis from myo-inositol and an increased incorporation of chiro-[3H]inositol into phospholipid in the Goto-Kakizaki (G.K) rat, Mol Cells, vol.8, pp.301-310, 1998. ,
Genetic regulation of mouse liver metabolite levels, Molecular Systems Biology, vol.10, issue.5, p.730, 2014. ,
DOI : 10.15252/msb.20135004
A metabolomic and systems biology perspective on the brain of the Fragile X syndrome mouse model, Genome Research, vol.21, issue.12, pp.2190-202, 2011. ,
DOI : 10.1101/gr.116764.110
URL : https://hal.archives-ouvertes.fr/hal-00724490
Chronic treatment with myo-inositol reduces white adipose tissue accretion and improves insulin sensitivity in female mice, The Journal of Nutritional Biochemistry, vol.24, issue.2, pp.457-66, 2013. ,
DOI : 10.1016/j.jnutbio.2012.01.008
URL : https://hal.archives-ouvertes.fr/hal-00759518
Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance, J Biol Chem, vol.266, pp.4706-4718, 1991. ,
Altered regulation of insulin signaling components in adipocytes of insulin-resistant type II diabetic goto-kakizaki rats, Metabolism, vol.47, issue.1, pp.54-62, 1998. ,
DOI : 10.1016/S0026-0495(98)90193-7
Stitching together Multiple Data Dimensions Reveals Interacting Metabolomic and Transcriptomic Networks That Modulate Cell Regulation, PLoS Biology, vol.103, issue.4, p.1001301, 2012. ,
DOI : 10.1371/journal.pbio.1001301.s025
URL : http://doi.org/10.1371/journal.pbio.1001301
Genetic Networks of Liver Metabolism Revealed by Integration of Metabolic and Transcriptional Profiling, PLoS Genetics, vol.7, issue.3, p.1000034, 2008. ,
DOI : 10.1371/journal.pgen.1000034.s006
Genetic control of plasma lipid levels in a cross derived from normoglycaemic ,
MetaboNetworks, an interactive Matlab-based toolbox for creating, customizing and exploring sub-networks from KEGG, Bioinformatics, vol.30, issue.6, pp.893-898, 2014. ,
DOI : 10.1093/bioinformatics/btt612
URL : https://academic.oup.com/bioinformatics/article-pdf/30/6/893/17345254/btt612.pdf
Marker-assisted congenic screening ( MACS ): A database tool for the efficient production and characterization of congenic lines, Mammalian Genome, vol.14, issue.5, pp.350-356, 2003. ,
DOI : 10.1007/s00335-002-3058-6
Integrated pathway-level analysis of transcriptomics and metabolomics data with IMPaLA, Bioinformatics, vol.27, issue.20, pp.2917-2925, 2011. ,
DOI : 10.1093/bioinformatics/btr499
AMBIENT: Active Modules for Bipartite Networks - using high-throughput transcriptomic data to dissect metabolic response, BMC Systems Biology, vol.7, issue.1, p.26, 2013. ,
DOI : 10.1007/BF01908075
URL : https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/1752-0509-7-26?site=bmcsystbiol.biomedcentral.com
Production of Spontaneous Diabetic Rats by Repetition of Selective Breeding, The Tohoku Journal of Experimental Medicine, vol.119, issue.1, pp.85-90, 1976. ,
DOI : 10.1620/tjem.119.85
Mapping diabetes QTL in an intercross derived from a congenic strain of the Brown Norway and Goto-Kakizaki rats, Mammalian Genome, vol.14, issue.6, pp.538-585, 2006. ,
DOI : 10.1007/s00335-005-0168-y
Enhanced insulin secretion and cholesterol metabolism in congenic strains of the spontaneously diabetic (Type 2) Goto Kakizaki rat are controlled by independent genetic loci in rat chromosome 8, Diabetologia, vol.47, issue.6, pp.1096-106, 2004. ,
DOI : 10.1007/s00125-004-1416-5
Quantitative trait locus dissection in congenic strains of the Goto-Kakizaki rat identifies a region conserved with diabetes loci in human chromosome 1q, Physiological Genomics, vol.19, issue.1, pp.1-10, 2004. ,
DOI : 10.1152/physiolgenomics.00114.2004
URL : https://hal.archives-ouvertes.fr/hal-00091557
Genome Sequencing Reveals Loci under Artificial Selection that Underlie Disease Phenotypes in the Laboratory Rat, Cell, vol.154, issue.3, pp.691-703, 2013. ,
DOI : 10.1016/j.cell.2013.06.040
The Gene INPPL1, Encoding the Lipid Phosphatase SHIP2, Is a Candidate for Type 2 Diabetes In Rat and Man, Diabetes, vol.51, issue.7, pp.2012-2019, 2002. ,
DOI : 10.2337/diabetes.51.7.2012
H NMR Spectroscopic Metabonomic Studies, Analytical Chemistry, vol.77, issue.2, pp.517-543, 2005. ,
DOI : 10.1021/ac048803i
KEGGgraph: a graph approach to KEGG PATHWAY in R and bioconductor, Bioinformatics, vol.25, issue.11, pp.1470-1471, 2009. ,
DOI : 10.1093/bioinformatics/btp167
Systems genetics approaches to understand complex traits, Nature Reviews Genetics, vol.45, issue.1, pp.34-48, 2014. ,
DOI : 10.2337/db11-1378
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934510