Hepatocellular carcinoma: epidemiology and molecular carcinogenesis, Gastroenterology, vol.132, issue.7, pp.2557-2576, 2007. ,
,
, Genotype-phenotype correlation of CTNNB1 mutations reveals different b-catenin activity associated with liver tumor progression, Hepatology, vol.64, issue.6, pp.2047-2061, 2016.
Genetic Landscape and Biomarkers of Hepatocellular Carcinoma, Gastroenterology, vol.149, issue.5, pp.1226-1239, 2015. ,
Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets, Nat Genet, vol.47, issue.5, pp.505-511, 2015. ,
URL : https://hal.archives-ouvertes.fr/inserm-01159736
Wholegenome mutational landscape and characterization of noncoding and structural mutations in liver cancer, Nat Genet, vol.48, issue.5, pp.500-509, 2016. ,
,
, Histological Subtypes of Hepatocellular Carcinoma Are Related To Gene Mutations and Molecular Tumour Classification, J Hepatol, vol.67, issue.4, pp.727-738, 2017.
, The roles of APC and 8
,
, Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas, Proc Natl Acad Sci U S A, vol.101, issue.49, pp.17216-17221, 2004.
,
, mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1, Nat Genet, vol.24, issue.3, pp.245-250, 2000.
,
Differential effects of inactivated Axin1 and activated beta-catenin mutations in human hepatocellular carcinomas, Oncogene, vol.26, issue.5, pp.774-780, 2007. ,
Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets, Hepatology, vol.45, issue.1, pp.42-52, 2007. ,
URL : https://hal.archives-ouvertes.fr/inserm-00130313
Conditional disruption of Axin1 leads to development of liver tumors in mice, Gastroenterology, vol.143, issue.6, pp.1650-1659, 2012. ,
New targets of b-catenin signaling in the liver are involved in the glutamine metabolism ,
, Oncogene, vol.21, issue.54, pp.8293-301, 2002.
Tbx3 is a downstream target of the Wnt/beta-catenin pathway and a critical mediator of betacatenin survival functions in liver cancer, Cancer Res, vol.67, issue.3, pp.901-911, 2007. ,
,
,
Apc tumor suppressor gene is the "zonation-keeper" of mouse liver, Dev Cell, vol.10, issue.6, pp.759-70, 2006. ,
TRIB2 acts downstream of Wnt/TCF in liver cancer cells to regulate YAP and C/EBPa function ,
, Mol Cell, vol.51, issue.2, pp.211-236, 2013.
Genomic profiling of hepatocellular adenomas reveals recurrent FRK-activating mutations and the mechanisms of malignant transformation, Cancer Cell, vol.25, issue.4, pp.428-469, 2014. ,
,
, Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma, Nat Genet, vol.44, issue.6, pp.694-702, 2012.
,
, Cholestasis is a marker for hepatocellular carcinomas displaying beta-catenin mutations, J Pathol, vol.212, issue.3, pp.345-52, 2007.
,
, Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma, Cancer Res, vol.69, issue.18, pp.7385-7392, 2009.
Focal gains of VEGFA and molecular classification of hepatocellular carcinoma, Cancer Res, vol.68, issue.16, pp.6779-6788, 2008. ,
Up-regulation of annexin ,