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A. Abd-alla, F. Jousset, Y. Li, G. Fediere, F. Cousserans et al., NS-3 Protein of the Junonia coenia Densovirus Is Essential for Viral DNA Replication in an Ld 652 Cell Line and Spodoptera littoralis Larvae, Journal of Virology, vol.78, issue.2, pp.790-797, 2004.
DOI : 10.1128/JVI.78.2.790-797.2004

B. Afanasiev and J. Carlson, Densovirinae as Gene Transfer Vehicles, Parvoviruses: From Molecular Biology to Pathology and Therapeutic Uses. Basel: Karger, vol.4, pp.33-58, 2000.
DOI : 10.1159/000060330

S. Altschul, T. Madden, A. Schaffer, J. Zhang, Z. Zhang et al., Gapped BLAST and PSI-BLAST: a new generation of protein database search programs, Nucleic Acids Research, vol.25, issue.17, pp.3389-3402, 1997.
DOI : 10.1093/nar/25.17.3389

R. Batchu, M. Shammas, J. Wang, and N. Munshi, Dual Level Inhibition of E2F-1 Activity by Adeno-associated Virus Rep78, Journal of Biological Chemistry, vol.71, issue.26, pp.24315-24322, 2001.
DOI : 10.1101/gad.7.7a.1111

URL : http://www.jbc.org/content/276/26/24315.full.pdf

S. Belloncik, Potential use of densonucleosis virus as biological control agents of insect pests, Handbook of Parvoviruses. Boca Raton, pp.29-39, 1990.

M. Bergoin and P. Tijssen, Biological and Molecular Properties of Densoviruses and Their Use in Protein Expression and Biological Control, The Insect Viruses, pp.141-169, 1998.
DOI : 10.1007/978-1-4615-5341-0_6

H. Bossin, P. Fournier, C. Royer, P. Barry, P. Cerutti et al., Junonia coenia Densovirus-Based Vectors for Stable Transgene Expression in Sf9 Cells: Influence of the Densovirus Sequences on Genomic Integration, Journal of Virology, vol.77, issue.20, pp.11060-11071, 2003.
DOI : 10.1128/JVI.77.20.11060-11071.2003

URL : https://hal.archives-ouvertes.fr/hal-00195290

H. Bossin, R. Furlong, J. Gillett, M. Bergoin, and P. Shirk, Somatic transformation efficiencies and expression patterns using the JcDNV and piggyBac transposon gene vectors in insects, Insect Molecular Biology, vol.72, issue.1, pp.37-47, 2007.
DOI : 10.1046/j.0962-1075.2001.00276.x

S. Cotmore, M. Agbandje-mckenna, J. Chiorini, D. Mukha, D. Pintel et al., The family Parvoviridae, Archives of Virology, vol.155, issue.84, pp.1239-1247, 2014.
DOI : 10.1007/s00705-010-0831-9

URL : https://link.springer.com/content/pdf/10.1007%2Fs00705-013-1914-1.pdf

J. Corsini, J. Tal, and E. Winocour, Directed integration of minute virus of mice DNA into episomes, Journal of Virology, vol.71, pp.9008-9015, 1997.

E. Alencon, P. Piffanelli, A. Volkoff, X. Sabau, S. Gimenez et al., A genomic BAC library and a new BAC-GFP vector to study the holocentric pest Spodoptera frugiperda, Insect Biochemistry and Molecular Biology, vol.34, issue.4, pp.331-341, 2004.
DOI : 10.1016/j.ibmb.2003.12.004

E. Alencon, H. Sezutsu, F. Legeai, E. Permal, S. Bernard-samain et al., Extensive synteny conservation of holocentric chromosomes in Lepidoptera despite high rates of local genome rearrangements, Proceedings of the National Academy of Sciences, vol.107, issue.17, pp.7680-7685, 2010.
DOI : 10.1101/gr.086009.108

URL : https://hal.archives-ouvertes.fr/inria-00537908

L. Daeffler, R. Horlein, J. Rommelaere, and J. Nuesch, Modulation of Minute Virus of Mice Cytotoxic Activities through Site-Directed Mutagenesis within the NS Coding Region, Journal of Virology, vol.77, issue.23, pp.12466-12478, 2003.
DOI : 10.1128/JVI.77.23.12466-12478.2003

S. Daya, N. Cortez, and K. Berns, Adeno-Associated Virus Site-Specific Integration Is Mediated by Proteins of the Nonhomologous End-Joining Pathway, Journal of Virology, vol.83, issue.22, pp.11655-11664, 1128.
DOI : 10.1128/JVI.01040-09

C. Ding, M. Urabe, M. Bergoin, and R. Kotin, Biochemical Characterization of Junonia coenia Densovirus Nonstructural Protein NS-1, Journal of Virology, vol.76, issue.1, 2002.
DOI : 10.1128/JVI.76.1.338-345.2002

URL : https://jvi.asm.org/content/76/1/338.full.pdf

B. Dumas, J. M. Pascaud, A. Bergoin, and M. , Complete nucleotide sequence of the cloned infectious genome of Junonia coenia densovirus reveals an organization unique among parvoviruses, Virology, vol.191, issue.1, pp.202-222, 1992.
DOI : 10.1016/0042-6822(92)90182-O

G. Fediere, Epidemiology and pathology of Densovirinae, Parvoviruses: From Molecular Biology to Pathology and Therapeutic Uses. Basel: Karger, vol.4, pp.1-11, 2000.

R. Goodwin, G. Tompkins, and P. Mccawley, Gypsy moth cell lines divergent in viral susceptibility, In Vitro, vol.13, issue.1970, pp.485-494, 1978.
DOI : 10.1093/jmedent/10.5.488

A. Gouin, A. Bretaudeau, K. Nam, S. Gimenez, J. Aury et al., Two genomes of highly polyphagous lepidopteran pests (Spodoptera frugiperda, Noctuidae) with different host-plant ranges, Scientific Reports, vol.42, issue.1, pp.11816-11826, 1038.
DOI : 10.1186/1471-2164-11-405

URL : https://hal.archives-ouvertes.fr/hal-01633879

J. Gu, M. Liu, Y. Deng, H. Peng, and X. Chen, Development of an Efficient Recombinant Mosquito Densovirus-Mediated RNA Interference System and Its Preliminary Application in Mosquito Control, PLoS ONE, vol.25, issue.6, 2011.
DOI : 10.1371/journal.pone.0021329.s001

P. Hendrie, R. Hirata, and D. Russell, Chromosomal Integration and Homologous Gene Targeting by Replication-Incompetent Vectors Based on the Autonomous Parvovirus Minute Virus of Mice, Journal of Virology, vol.77, issue.24, pp.13136-13145, 2003.
DOI : 10.1128/JVI.77.24.13136-13145.2003

I. Hewson, J. Button, B. Gudenkauf, B. Miner, A. Newton et al., Densovirus associated with sea-star wasting disease and mass mortality, Proceedings of the National Academy of Sciences, vol.71, issue.12, pp.17278-17283, 2014.
DOI : 10.1093/biomet/69.3.553

URL : http://www.pnas.org/content/111/48/17278.full.pdf

T. Janovitz, I. Klein, T. Oliveira, P. Mukherjee, M. Nussenzweig et al., High-Throughput Sequencing Reveals Principles of Adeno-Associated Virus Serotype 2 Integration, Journal of Virology, vol.87, issue.15, pp.8559-8568, 1128.
DOI : 10.1128/JVI.01135-13

A. Katzourakis and R. Gifford, Endogenous Viral Elements in Animal Genomes, PLoS Genetics, vol.13, issue.11, 2010.
DOI : 10.1371/journal.pgen.1001191.s010

URL : https://doi.org/10.1371/journal.pgen.1001191

D. Legendre and J. Rommelaere, Targeting of promoters for trans activation by a carboxyterminal domain of the NS-1 protein of the parvovirus minute virus of mice, Journal of Virology, vol.68, pp.7974-7985, 1994.

H. Liu, Y. Fu, J. Xie, J. Cheng, S. Ghabrial et al., Widespread Endogenization of Densoviruses and Parvoviruses in Animal and Human Genomes, Journal of Virology, vol.85, issue.19, pp.9863-9876, 1128.
DOI : 10.1128/JVI.00828-11

A. Mange, E. Julien, J. Prudhomme, and P. Couble, A strong inhibitory element down-regulates SRE-stimulated transcription of the A3 cytoplasmic actin gene of Bombyx mori, Journal of Molecular Biology, vol.265, issue.3, pp.266-274, 1996.
DOI : 10.1006/jmbi.1996.0734

R. Nalcacioglu, H. Marks, J. Vlak, Z. Demirbag, and M. Van-oers, Promoter analysis of the Chilo iridescent virus DNA polymerase and major capsid protein genes, Virology, vol.317, issue.2, pp.321-329, 2003.
DOI : 10.1016/j.virol.2003.08.007

K. Nash, W. Chen, M. Salganik, and N. Muzyczka, Identification of Cellular Proteins That Interact with the Adeno-Associated Virus Rep Protein, Journal of Virology, vol.83, issue.1, pp.454-469, 1128.
DOI : 10.1128/JVI.01939-08

J. Nuesch, J. Kerr, S. Cotmore, and M. Bloom, Regulation of non-structural protein functions by differential synthesis, modification and trafficking, pp.275-289, 2006.
DOI : 10.1201/b13393-24

H. Ochman, F. Ayala, and D. Hartl, Use of Polymerase Chain Reaction to Amplify Segments Outside Boundaries of Known Sequences, Methods in Enzymology, vol.218, issue.93, pp.309-321, 1993.
DOI : 10.1016/B978-0-12-765561-1.50046-1

R. Team, R: A Language and Environment for Statistical Computing Vienna: R Foundation for Statistical Computing, 2014.

C. Royer, H. Bossin, C. Romane, M. Bergoin, and P. Couble, High amplification of a densovirusderived vector in larval and adult tissues of Drosophila, Insect Molecular Biology, vol.10, issue.3, 2001.

C. Sallaud, D. Meynard, J. Van-boxtel, C. Gay, M. Bes et al., Highly efficient production and characterization of T-DNA plants for rice (Oryza sativa L.) functional genomics, Theoretical and Applied Genetics, vol.296, issue.8, pp.1396-1408, 2003.
DOI : 10.1126/science.1068037

J. Sambrook, E. Fritsch, and T. Maniatis, Molecular Cloning: A Laboratory Manual, 1989.

P. Shirk, H. Bossin, R. Furlong, and J. Gillett, Regulation of Junonia coenia densovirus P9 promoter expression, Insect Molecular Biology, vol.12, issue.0, pp.623-633, 2007.
DOI : 10.1128/JVI.77.19.10357-10365.2003

J. Tal and T. Attathom, Insecticidal potential of the insect parvovirus GmDNV, Archives of Insect Biochemistry and Physiology, vol.22, pp.3-4345, 1993.
DOI : 10.1002/arch.940220304

J. Theze, S. Leclercq, B. Moumen, R. Cordaux, and C. Gilbert, Remarkable Diversity of Endogenous Viruses in a Crustacean Genome, Genome Biology and Evolution, vol.32, issue.8, pp.2129-2140, 2014.
DOI : 10.1111/j.1574-6976.2008.00123.x

URL : https://hal.archives-ouvertes.fr/hal-01078498

J. Vaughn, R. Goodwin, G. Tompkins, and P. Mccawley, The establishment of two cell lines from the insectspodoptera frugiperda (lepidoptera; noctuidae), In Vitro, vol.25, issue.4, pp.213-217, 1977.
DOI : 10.1016/B978-0-12-429740-1.50037-0

Y. Wang, A. Abd-alla, H. Bossin, Y. Li, and M. Bergoin, Analysis of the transcription strategy of the Junonia coenia densovirus (JcDNV) genome, Virus Research, vol.174, issue.1-2, pp.101-107, 2014.
DOI : 10.1016/j.virusres.2013.03.008

B. Yang, J. Zhang, D. Cai, D. Li, W. Chen et al., Biochemical characterization of Periplaneta fuliginosa densovirus non-structural protein NS1, Biochemical and Biophysical Research Communications, vol.342, issue.4, pp.1188-1196, 2006.
DOI : 10.1016/j.bbrc.2006.02.053

K. Ziegler, T. Bui, R. Frisque, A. Grandinetti, and V. Nerurkar, A rapid in vitro polyomavirus DNA replication assay, Journal of Virological Methods, vol.122, issue.1, pp.123-127, 2004.
DOI : 10.1016/j.jviromet.2004.08.012