A. Alfonso-pecchio, M. Garcia, R. Leonardi, and S. Jackowski, Compartmentalization of mammalian pantothenate kinases, PLoS One, vol.7, p.49509, 2012.

M. Aurrand-lions, F. Galland, H. Bazin, V. M. Zakharyev, B. A. Imhof et al., Vanin-1, a novel GPI-linked perivascular molecule involved in thymus homing, Immunity, vol.5, pp.391-405, 1996.

C. Berruyer, L. Pouyet, V. Millet, F. M. Martin, A. Legoffic et al., Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor gamma activity, J Exp Med, vol.203, pp.2817-2827, 2006.
URL : https://hal.archives-ouvertes.fr/hal-00165626

S. Bullman, C. S. Pedamallu, E. Sicinska, T. E. Clancy, X. Zhang et al., Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer, Science, vol.358, pp.1443-1448, 2017.

G. Bustos, P. Cruz, A. Lovy, and C. Cardenas, Endoplasmic reticulummitochondria calcium communication and the regulation of mitochondrial metabolism in cancer: A novel potential target, Front Oncol, vol.7, p.199, 2017.

A. Z. Buzatto, M. De-oliveira-silva, R. J. Poppi, and A. Simionato, Assessment of nucleosides as putative tumor biomarkers in prostate cancer screening by CE-UV, Anal Bioanal Chem, vol.409, pp.3289-3297, 2017.

A. Casazza, D. Conza, G. Wenes, M. Finisguerra, V. Deschoemaeker et al., Tumor stroma: A complexity dictated by the hypoxic tumor microenvironment, Oncogene, vol.33, pp.1743-1754, 2014.

C. H. Chang, J. Qiu, D. O'sullivan, M. D. Buck, T. Noguchi et al., Metabolic competition in the tumor microenvironment is a driver of cancer progression, Cell, vol.162, pp.1229-1241, 2015.

E. I. Chen, Mitochondrial dysfunction and cancer metastasis, J Bioenerg Biomembr, vol.44, pp.619-622, 2012.

F. Chibon, P. Lagarde, S. Salas, G. Perot, V. Brouste et al., Validated prediction of clinical outcome in sarcomas and multiple types of cancer on the basis of a gene expression signature related to genome complexity, Nature Med, vol.16, pp.781-787, 2010.
URL : https://hal.archives-ouvertes.fr/inserm-02438669

J. M. Coindre, Grading of soft tissue sarcomas: Review and update, Arch Pathol Lab Med, vol.130, pp.1448-1453, 2006.

O. R. Colegio, N. Q. Chu, A. L. Szabo, T. Chu, A. M. Rhebergen et al., Functional polarization of tumour-associated macrophages by tumour-derived lactic acid, Nature, vol.513, pp.559-563, 2014.

K. J. Dammanahalli, S. Stevens, and R. Terkeltaub, Vanin-1 pantetheinase drives smooth muscle cell activation in post-arterial injury neointimal hyperplasia, PLoS One, vol.7, p.39106, 2012.

D. Virgilio, F. Adinolfi, and E. , Extracellular purines, purinergic receptors and tumor growth, Oncogene, vol.36, pp.293-303, 2017.

S. Dusi, L. Valletta, T. B. Haack, Y. Tsuchiya, P. Venco et al., Exome sequence reveals mutations in CoA synthase as a cause of neurodegeneration with brain iron accumulation, Am J Hum Genet, vol.94, pp.11-22, 2014.

H. F. Dvorak, Tumors: Wounds that do not heal. Similarities between tumor stroma generation and wound healing, N Engl J Med, vol.315, pp.1650-1659, 1986.

M. A. Elmonem, K. R. Veys, N. A. Soliman, M. Van-dyck, L. P. Van-den-heuvel et al., Cystinosis: A review, Orphanet J Rare Dis, vol.11, p.47, 2016.

D. W. Ferreira, M. J. Goedken, S. Rommelaere, L. Chasson, F. Galland et al., Enhanced hepatotoxicity by acetaminophen in Vanin-1 knockout mice is associated with deficient proliferative and immune responses, Biochim Biophys Acta, vol.1862, pp.662-669, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01438514

G. Fiermonte, E. Paradies, S. Todisco, C. M. Marobbio, and F. Palmieri, A novel member of solute carrier family 25 (SLC25A42) is a transporter of coenzyme A and adenosine 39,59-diphosphate in human mitochondria, J Biol Chem, vol.284, pp.18152-18159, 2009.

Y. A. Fouad and C. Aanei, Revisiting the hallmarks of cancer, Am J Cancer Res, vol.7, pp.1016-1036, 2017.

L. Galluzzi, O. Kepp, M. G. Vander-heiden, and G. Kroemer, Metabolic targets for cancer therapy, Nat Rev Drug Discov, vol.12, pp.829-846, 2013.

L. T. Geller, M. Barzily-rokni, T. Danino, O. H. Jonas, N. Shental et al., Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine, Science, vol.357, pp.1156-1160, 2017.

A. H. Giang, T. Raymond, P. Brookes, M. De, K. Bentley et al., Mitochondrial dysfunction and permeability transition in osteosarcoma cells showing the Warburg effect, J Biol Chem, vol.288, pp.33303-33311, 2013.

R. Goosen and E. Strauss, Simultaneous quantification of coenzyme A and its salvage pathway intermediates in in vitro and whole cell-sourced samples, RSC Advances, vol.7, pp.19717-19724, 2017.

L. Huang, A. Khusnutdinova, B. Nocek, G. Brown, X. Xu et al., A family of metal-dependent phosphatases implicated in metabolite damage-control, Nat Chem Biol, vol.12, pp.621-627, 2016.

I. J. Huijbers, P. Krimpenfort, P. Chomez, M. A. Van-der-valk, J. Y. Song et al., Van den Eynde BJ (2006) An inducible mouse model of melanoma expressing a defined tumor antigen, Cancer Res, vol.66, pp.3278-3286

S. Jackowski and R. Co, Metabolism of 4'-phosphopantetheine in Escherichia coli, J Bacteriol, vol.158, pp.115-120, 1984.

D. Jacob, C. Deborde, M. Lefebvre, M. Maucourt, and A. Moing, NMRProcFlow: A graphical and interactive tool dedicated to 1D spectra processing for NMR-based metabolomics, Metabolomics, vol.13, p.36, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01401241

N. Kavian, W. Marut, A. Servettaz, C. Nicco, C. Chereau et al., Pantethine prevents murine systemic sclerosis through the inhibition of microparticle shedding, Arthritis Rheumatol, vol.67, pp.1881-1890, 2015.
URL : https://hal.archives-ouvertes.fr/hal-02016450

N. Kavian, S. Mehlal, W. Marut, A. Servettaz, C. Giessner et al., Imbalance of the Vanin-1 pathway in systemic sclerosis, J Immunol, vol.197, pp.3326-3335, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01438160

E. M. Kerr, E. Gaude, F. K. Turrell, C. Frezza, and C. P. Martins, Mutant Kras copy number defines metabolic reprogramming and therapeutic susceptibilities, Nature, vol.531, pp.110-113, 2016.

R. Leonardi, C. O. Rock, S. Jackowski, and Y. M. Zhang, Activation of human mitochondrial pantothenate kinase 2 by palmitoylcarnitine, 2007.

, Proc Natl Acad Sci, vol.104, pp.1494-1499

Y. Li, Y. Chang, L. Zhang, Q. Feng, Z. Liu et al., High glucose upregulates pantothenate kinase 4 (PanK4) and thus affects M2-type pyruvate kinase (Pkm2), Mol Cell Biochem, vol.277, pp.117-125, 2005.

M. P. Lisanti, U. E. Martinez-outschoorn, and F. Sotgia, Oncogenes induce the cancer-associated fibroblast phenotype: Metabolic symbiosis and "fibroblast addiction" are new therapeutic targets for drug discovery, Cell Cycle, vol.12, pp.2723-2732, 2013.

W. Liu, B. H. Beck, K. S. Vaidya, K. T. Nash, A. R. Diers et al., The KISS1 metastasis suppressor appears to reverse the Warburg effect by enhancing mitochondria biogenesis, Cancer Res, vol.74, pp.954-963, 2013.

J. R. Lu, M. Tan, and Q. S. Cai, The Warburg effect in tumor progression: Mitochondrial oxidative metabolism as an anti-metastasis mechanism, Cancer Lett, vol.356, pp.156-164, 2015.

B. Maras, D. Barra, S. Dupre, and G. Pitari, Is pantetheinase the actual identity of mouse and human vanin-1 proteins?, FEBS Lett, vol.461, pp.149-152, 1999.

F. Martin, M. F. Penet, F. Malergue, H. Lepidi, A. Dessein et al., Vanin-1(-/-) mice show decreased NSAIDand Schistosoma-induced intestinal inflammation associated with higher glutathione stores, J Clin Invest, vol.113, pp.591-597, 2004.

J. C. Martin, M. Maillot, G. Mazerolles, A. Verdu, B. Lyan et al., Can we trust untargeted metabolomics? Results of the metabo-ring initiative, a large-scale, multi-instrument inter-laboratory study, Metabolomics, vol.11, pp.807-821, 2015.

M. C. Mimmi, N. Finato, G. Pizzolato, C. A. Beltrami, F. Fogolari et al., Absolute quantification of choline-related biomarkers in breast cancer biopsies by liquid chromatography electrospray ionization mass spectrometry, Anal Cell Pathol (Amst), vol.36, pp.71-83, 2013.

A. R. Mullen, W. W. Wheaton, J. E. Chen, P. H. Sullivan, L. B. Cheng et al., Reductive carboxylation supports growth in tumour cells with defective mitochondria, Nature, vol.481, pp.385-171, 2012.

P. Naquet, G. Pitari, S. Dupre, and F. Galland, Role of the Vnn1 pantetheinase in tissue tolerance to stress, Biochem Soc Trans, vol.42, pp.1094-1100, 2014.

J. K. Nicholson, P. J. Foxall, M. Spraul, R. D. Farrant, and J. C. Lindon, , p.750, 1995.

, MHz 1H and 1H-13C NMR spectroscopy of human blood plasma, Anal Chem, vol.67, pp.793-811

M. F. Penet, M. Abou-hamdan, N. Coltel, E. Cornille, G. E. Grau et al., Protection against cerebral malaria by the low-molecularweight thiol pantethine, Proc Natl Acad Sci, vol.105, pp.1321-1326, 2008.

F. Pietrocola, L. Galluzzi, J. M. Bravo-san-pedro, F. Madeo, and G. Kroemer, Acetyl coenzyme A: A central metabolite and second messenger, Cell Metab, vol.21, pp.805-821, 2015.

G. Pitari, F. Malergue, F. Martin, J. M. Philippe, M. T. Massucci et al., Pantetheinase activity of membrane-bound Vanin-1: Lack of free cysteamine in tissues of Vanin-1 deficient mice, FEBS Lett, vol.483, pp.2110-2114, 2000.

J. L. Ray, R. Leach, J. M. Herbert, and M. Benson, Isolation of vascular smooth muscle cells from a single murine aorta, Methods Cell Sci, vol.23, pp.185-188, 2001.

H. W. Rhee, P. Zou, N. D. Udeshi, J. D. Martell, V. K. Mootha et al., Proteomic mapping of mitochondria in living cells via spatially restricted enzymatic tagging, Science, vol.339, pp.1328-1331, 2013.

S. Rommelaere, V. Millet, T. Gensollen, C. Bourges, J. Eeckhoute et al., PPARalpha regulates the production of serum Vanin-1 by liver, FEBS Lett, vol.587, pp.3742-3748, 2013.

S. Rommelaere, V. Millet, T. Gensollen, C. Bourges, J. Eeckhoute et al., PPARalpha regulates the production of serum Vanin-1 by liver, FEBS Lett, vol.587, pp.3742-3748, 2013.

B. H. Ruan, D. C. Cole, P. Wu, A. Quazi, K. Page et al., A fluorescent assay suitable for inhibitor screening and vanin tissue quantification, Analyt Biochem, vol.399, pp.284-292, 2010.

Y. Shapovalov, D. Hoffman, D. Zuch, M. De, K. L. Bentley et al., Mitochondrial dysfunction in cancer cells due to aberrant mitochondrial replication, J Biol Chem, vol.286, pp.22331-22338, 2011.

N. E. Sharpless, S. Alson, S. Chan, D. P. Silver, D. H. Castrillon et al., (INK4a) and p53 deficiency cooperate in tumorigenesis, Cancer Res, vol.62, pp.2761-2765, 2002.

K. Siudeja, B. Srinivasan, L. Xu, R. A. De-jong, J. Nollen et al., Impaired Coenzyme A metabolism affects histone and tubulin acetylation in Drosophila and human cell models of pantothenate kinase associated neurodegeneration, EMBO Mol Med, vol.3, pp.755-766, 2011.

L. Spinelli, S. Carpentier, M. Sanchis, F. Dalod, M. Vu-manh et al., BubbleGUM: Automatic extraction of phenotype molecular signatures and comprehensive visualization of multiple gene set enrichment analyses, BMC Genom, vol.16, p.814, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01236135

B. Srinivasan, M. Baratashvili, M. Van-der-zwaag, B. Kanon, C. Colombelli et al., Extracellular 49-phosphopantetheine is a source for intracellular coenzyme A synthesis, Nat Chem Biol, vol.11, pp.784-792, 2015.

E. Strauss, Coenzyme A biosynthesis and enzymology, Comprehensive Natural Products II, pp.351-410, 2010.

C. Subramanian, M. K. Yun, J. Yao, L. K. Sharma, R. E. Lee et al., Allosteric regulation of mammalian pantothenate kinase, J Biol Chem, vol.291, pp.22302-22314, 2016.

G. Tan, H. Wang, J. Yuan, W. Qin, X. Dong et al., Three serum metabolite signatures for diagnosing low-grade and high-grade bladder cancer, Scientific Rep, vol.7, p.46176, 2017.

T. Terada, T. Hara, H. Yazawa, and T. Mizoguchi, Effect of thioltransferase on the cystamine-activated fructose 1,6-bisphosphatase by its redox regulation, Biochem Mol Biol Int, vol.32, pp.239-244, 1994.

F. M. Van-der-kloet, I. Bobeldijk, E. R. Verheij, and R. H. Jellema, Analytical error reduction using single point calibration for accurate and precise metabolomic phenotyping, J Proteome Res, vol.8, pp.5132-5141, 2009.

J. A. Van-diepen, P. A. Jansen, D. B. Ballak, A. Hijmans, G. J. Hooiveld et al., PPAR-alpha dependent regulation of vanin-1 mediates hepatic lipid metabolism, J Hepatol, vol.61, pp.366-372, 2014.

M. G. Vander-heiden, L. C. Cantley, and C. B. Thompson, Understanding the Warburg effect: The metabolic requirements of cell proliferation, Science, vol.324, pp.1029-1033, 2009.

A. Vozza, F. De-leonardis, E. Paradies, D. Grassi, A. Pierri et al., Biochemical characterization of a new mitochondrial transporter of dephosphocoenzyme A in Drosophila melanogaster, Biochim Biophys Acta, vol.1858, pp.137-146, 2017.

J. B. West, Z. Fu, T. J. Deerinck, M. R. Mackey, J. T. Obayashi et al., Structure-function studies of blood and air capillaries in chicken lung using 3D electron microscopy, Respir Physiol Neurobiol, vol.170, pp.202-209, 2010.

D. S. Wishart, T. Jewison, A. C. Guo, M. Wilson, C. Knox et al., HMDB 3.0: The human metabolome database in 2013, Nucleic Acids Res, vol.41, pp.801-807, 2013.

C. T. Wittwer, W. A. Gahl, J. D. Butler, M. Zatz, and J. G. Thoene, Metabolism of pantethine in cystinosis, License: This article is available under a Creative Commons License, vol.76, pp.1665-1672, 1985.