Recent trends in HIV-1 drug resistance, Curr. Opin. Virol, vol.3, pp.487-494, 2013. ,
HIV-1 eradication strategies: design and assessment, Curr. Opin. HIV AIDS, vol.8, pp.318-325, 2013. ,
Recent developments in the search for a cure for HIV-1 infection: targeting the latent reservoir for HIV-1, J. Allergy Clin. Immunol, vol.134, pp.12-19, 2014. ,
Cold Spring Harb, Perspect. Med, vol.1, p.7096, 2012. ,
Perspectives on antiviral drug development, Antiviral Res, vol.81, pp.1-5, 2009. ,
HIV-1 antiretroviral drug therapy. Cold Spring Harb Perspect, vol.2, p.7161, 2012. ,
Genetic modification of hematopoietic stem cells as a therapy for HIV/AIDS, Viruses, vol.5, pp.2946-2962, 2013. ,
The CRISPR/Cas9 system inactivates latent HIV-1 proviral DNA, Retrovirology, vol.12, p.22, 2015. ,
Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication, Nat. Chem. Biol, vol.6, pp.442-448, 2010. ,
LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions, Retrovirology, vol.10, p.57, 2013. ,
Retroviral DNA integration: HIV and the role of LEDGF/p75, Trends Genet, vol.22, pp.388-395, 2006. ,
Intracellular kinase inhibitors selected from combinatorial libraries of designed ankyrin repeat proteins, J. Biol. Chem, vol.280, pp.24715-24722, 2005. ,
High-affinity binders selected from designed ankyrin repeat protein libraries, Nat. Biotechnol, vol.22, pp.575-582, 2004. ,
Engineering novel binding proteins from nonimmunoglobulin domains, Nat. Biotech, vol.23, pp.1257-1268, 2005. ,
Engineered proteins as specific binding reagents, Curr. Opin. Biotechnol, vol.16, pp.459-469, 2005. ,
Designing repeat proteins: well-expressed, soluble and stable proteins from combinatorial libraries of consensus ankyrin repeat proteins, J. Mol. Biol, vol.332, pp.489-503, 2003. ,
DARPins and other repeat protein scaffolds: advances in engineering and applications, Curr. Opin. Biotechnol, vol.22, pp.849-857, 2011. ,
Designed ankyrin repeat proteins (DARPins) from research to therapy, Methods Enzymol, vol.503, pp.101-135, 2012. ,
The emerging role of new protein scaffold-based agents for treatment of cancer, Cancer Genomics Proteomics, vol.10, pp.155-168, 2013. ,
CD4-specific designed ankyrin repeat proteins are novel potent HIV entry inhibitors with unique characteristics, PLoS Pathog, vol.4, p.1000109, 2008. ,
Appraisal of translocation pathways for displaying ankyrin repeat protein on phage particles, Protein Expr. Purif, vol.74, pp.156-161, 2010. ,
Antiviral activity of recombinant ankyrin targeted to the capsid domain of HIV-1 Gag polyprotein, Retrovirology, vol.9, p.17, 2012. ,
Zinc finger protein designed to target 2-long terminal repeat junctions interferes with human immunodeficiency virus integration, Hum. Gene Ther, vol.23, pp.932-942, 2012. ,
Designed zinc finger protein interacting with the HIV-1 integrase recognition sequence at 2-LTR-circle junctions, Protein Sci, vol.18, pp.2219-2230, 2009. ,
Combined antiviral therapy using designed molecular scaffolds targeting two distinct viral functions, HIV-1 genome integration and capsid assembly, Mol. Ther. -Nucl. Acids, vol.4, p.249, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-02192911
Specific GFP-binding artificial proteins (?Rep): a new tool for in vitro to live cell applications, SCIenTIFIC REPoRTS |, vol.7, p.223, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-01223908
Selection of specific protein binders for pre-defined targets from an optimized library of artificial helicoidal repeat proteins (alphaRep), PLoS One, vol.8, p.71512, 2013. ,
Design, production and molecular structure of a new family of artificial alpha-helicoidal repeat proteins (alphaRep) based on thermostable HEAT-like repeats, J. Mol. Biol, vol.404, pp.307-327, 2010. ,
Artificial proteins from combinatorial approaches, Trends Biotechnol, vol.30, pp.512-520, 2012. ,
Betulinic acid derivatives as HIV-1 antivirals, Trends Mol. Med, vol.11, pp.31-36, 2005. ,
The 3-O-(3?,3?-dimethylsuccinyl) derivative of betulinic acid (DSB) inhibits the assembly of virus-like particles in HIV-1 Gag precursor-expressing cells, Antiviral Ther, vol.12, pp.1185-1203, 2007. ,
URL : https://hal.archives-ouvertes.fr/hal-02122515
The inhibition of assembly of HIV-1 virus-like particles by 3-O-(3?,3?-dimethylsuccinyl) betulinic acid (DSB) is counteracted by Vif and requires its Zinc-binding domain, Virol. J, vol.5, p.162, 2008. ,
URL : https://hal.archives-ouvertes.fr/hal-02122505
Characterization of a novel type of HIV-1 particle assembly inhibitor using a quantitative luciferase-Vpr packaging-based assay, PLoS One, vol.6, p.27234, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-02122413
The sequence of the CA-SP1 junction accounts for the differential sensitivity of HIV-1 and SIV to the small molecule maturation inhibitor 3-O-{3?,3?-dimethylsuccinyl}-betulinic acid, Retrovirology, vol.1, p.15, 2004. ,
Inhibition of HIV-1 maturation via drug association with the viral Gag protein in immature HIV-1 particles, J. Biol. Chem, vol.280, pp.42149-42155, 2005. ,
Mapping of functionally important residues of a cysteinehistidine box in the human immunodeficiency virus type 1 nucleocapsid protein, J. Virol, vol.67, pp.6159-6169, 1993. ,
Nucleocapsid protein of human immunodeficiency virus as a model protein with chaperoning functions and as a target for antiviral drugs, Adv. Pharmacol, vol.48, pp.345-372, 2000. ,
Properties, functions, and drug targeting of the multifunctional nucleocapsid protein of the human immunodeficiency virus, Adv. Pharmacol, vol.55, pp.299-346, 2007. ,
URL : https://hal.archives-ouvertes.fr/hal-00667232
HIV-1 nucleocapsid traps reverse transcriptase on nucleic acid substrates, Biochemistry, vol.47, pp.12230-12240, 2008. ,
URL : https://hal.archives-ouvertes.fr/hal-00339361
Nucleic acid chaperone activity of HIV-1 nucleocapsid protein: critical role in reverse transcription and molecular mechanism, Prog. Nucleic Acid Res. Mol. Biol, vol.80, pp.217-286, 2005. ,
Identification of HIV-1 inhibitors targeting the nucleocapsid protein, J. Med. Chem, vol.55, pp.4968-4977, 2012. ,
Targeting the viral nucleocapsid protein in anti-HIV-1 therapy, Mini-Rev. Med. Chem, vol.8, pp.24-35, 2008. ,
URL : https://hal.archives-ouvertes.fr/hal-00246512
Advances in targeting nucleocapsid-nucleic acid interactions in HIV-1 therapy, Virus Res, vol.193, pp.135-143, 2014. ,
Nucleocapsid protein: a desirable target for future therapies against HIV-1, Curr. Top. Microbiol. Immunol, vol.389, pp.53-92, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-01186130
Identification of HIV-1 nucleocapsid protein: nucleic acid antagonists with cellular anti-HIV activity, Biochem. Biophys. Res. Commun, vol.296, pp.1228-1237, 2002. ,
The nucleocapsid region of HIV-1 Gag cooperates with the PTAP and LYPXnL late domains to recruit the cellular machinery necessary for viral budding, PLoS Pathog, vol.5, p.1000339, 2009. ,
Human immunodeficiency virus type 1 Gag engages the Bro1 domain of ALIX/ AIP1 through the nucleocapsid, J Virol, vol.82, pp.1389-1398, 2008. ,
Morphopoietic determinants of HIV-1 GAG particles assembled in baculovirus-infected cells, Virology, vol.247, pp.160-169, 1998. ,
URL : https://hal.archives-ouvertes.fr/hal-02147228
Assembly and release of HIV-1 precursor Pr55gag virus-like particles from recombinant baculovirus-infected insect cells, Cell, vol.59, pp.103-112, 1989. ,
Functional domains of HIV-1 gag-polyprotein expressed in baculovirus-infected cells, Virology, vol.184, pp.417-422, 1991. ,
Expression and extracellular release of human immunodeficiency virus type 1 Gag precursors by recombinant baculovirus-infected cells, J. Virol, vol.66, pp.3230-3235, 1992. ,
All about that fat: Lipid modification of proteins in Cryptococcus neoformans, J. Microbiol, vol.54, pp.212-222, 2016. ,
Incorporation of Vpr into human immunodeficiency virus type 1 requires a direct interaction with the p6 domain of the p55 gag precursor, J. Biol. Chem, vol.274, pp.9083-9091, 1999. ,
Biochemical analyses of the interactions between human immunodeficiency virus type 1 Vpr andp6(Gag), J. Virol, vol.75, pp.10537-10542, 2001. ,
Efficiency of human immunodeficiency virus type 1 postentry infection processes: evidence against disproportionate numbers of defective virions, J. Virol, vol.81, pp.4367-4370, 2007. ,
Features, processing states, and heterologous protein interactions in the modulation of the retroviral nucleocapsid protein function, RNA Biol, vol.7, pp.724-734, 2010. ,
The regulation of sequential processing of HIV-1 Gag by the viral protease, Adv. Exp. Med. Biol, vol.436, pp.15-25, 1998. ,
Expedient screening for HIV-1 protease inhibitors using a simplified immunochromatographic assay, J. Chromatogr. B Analyt. Technol. Biomed. Life Sci, vol.1021, pp.153-158, 2016. ,
A drug discovery platform: a simplified immunoassay for analyzing HIV protease activity, J. Virol. Methods, vol.186, pp.21-29, 2012. ,
Pairwise decomposition of residue interaction energies of single chain Fv with HIV-1p17 epitope variants, Mol. Immunol, vol.47, pp.982-990, 2010. ,
Relationships between infectious titer, capsid protein levels, and reverse transcriptase activities of diverse human immunodeficiency virus type 1 isolates, J. Virol, vol.78, pp.11130-11141, 2004. ,
Attenuation of HIV-1 replication in primary human cells with a designed zinc finger transcription factor, J. Biol. Chem, vol.279, pp.14509-14519, 2004. ,
T-cell line for HIV drug screening using GFP as a quantitative marker of HIV-1 replication, Biotechniques, vol.40, pp.91-100, 2006. ,
Flexibility in the p2 domain of the HIV-1Gag polyprotein, Protein Science, vol.13, pp.2101-2107, 2004. ,
Structures of the HIV-1 capsid protein dimerization domain at 2.6 A° resolution, Acta Cryst., Section D, Biol. Cryst, vol.55, pp.85-92, 1999. ,
Dimerization of the SP1 region of HIV-1 Gag induces a helical conformation and association into helical bundles: Implications for particle assembly, J Virol, vol.90, pp.1773-1787, 2015. ,
On the role of the SP1 domain in HIV-1 particle assembly: a molecular switch?, J. Virol, vol.85, pp.4111-4121, 2011. ,
, SCIenTIFIC REPoRTS |, vol.7
Crystal structure of an HIV assembly and maturation switch. eLife 5, e17063, 2016. ,
Determination of the structure of the nucleocapsid protein NCp7 from the human immunodeficiency virus type 1 by 1H NMR, EMBO J, vol.11, pp.3059-3065, 1992. ,
Structure of the zinc finger domain encompassing residues 13-51 of the nucleocapsid protein from simian immunodeficiency virus, Biochem. J, vol.393, pp.725-732, 2006. ,
URL : https://hal.archives-ouvertes.fr/hal-02122534
The conserved N-terminal basic residues and zinc-finger motifs of HIV-1 nucleocapsid restrict the viral cDNA synthesis during virus formation and maturation, Nucleic Acids Res, vol.36, pp.4745-4753, 2008. ,
URL : https://hal.archives-ouvertes.fr/hal-00311686
Human immunodeficiency virus type 1 Gag polyprotein multimerization requires the nucleocapsid domain and RNA and is promoted by the capsid-dimer interface and the basic region of matrix protein, J. Virol, vol.73, pp.8527-8540, 1999. ,
URL : https://hal.archives-ouvertes.fr/hal-02323113
Basic residues in human immunodeficiency virus type 1 nucleocapsid promote virion assembly via interaction with RNA, J. Virol, vol.74, pp.3046-3057, 2000. ,
URL : https://hal.archives-ouvertes.fr/hal-02323109
Live-cell observation of cytosolic HIV-1 assembly onset reveals RNA-interacting Gag oligomers, J. Cell Biol, vol.210, pp.629-646, 2015. ,
T-cell protection and enrichment through lentiviral CCR5 intrabody gene delivery, Gene Ther, vol.13, pp.1480-1492, 2006. ,
Protein ligands of human Adenovirus type 2 outer capsid identified by biopanning of a phage-displayed peptide library on separate domains of WT and mutant penton capsomers, EMBO J, vol.14, pp.4714-4727, 1995. ,
Adenovirus type 5 fiber knob binds to MHC class I alpha2 domain at the surface of human epithelial and B lymphoblastoid cells, EMBO J, vol.16, pp.2294-2306, 1997. ,
Interaction and co-encapsidation of HIV-1 Vif and Gag recombinant proteins, J. Gen. Virol, vol.79, pp.1069-1081, 1998. ,
Early selection in Gag by protective HLA alleles contributes to reduced HIV-1 replication capacity that may be largely compensated for in chronic infection, J. Virol, vol.84, pp.11937-11949, 2010. ,
Use of a novel GFP reporter cell line to examine replication capacity of CXCR4-and CCR5-tropic HIV-1 by flow cytometry, J. Virol. Methods, vol.131, pp.134-142, 2006. ,
Gag-protease-mediated replication capacity in HIV-1 subtype C chronic infection: associations with HLA type and clinical parameters, J. Virol, vol.84, pp.10820-10831, 2010. ,