Mutations of gonadotropins and gonadotropin receptors: elucidating the physiology and pathophysiology of pituitary-gonadal function, Endocr Rev, vol.21, pp.551-83, 2000. ,
The follicle-stimulating hormone receptor: biochemistry, molecular biology, physiology, and pathophysiology, Endocr Rev, vol.18, pp.739-73, 1997. ,
Human FSH? subunit gene is highly conserved, Mol Hum Reprod, vol.11, pp.601-606, 2005. ,
Specific roles for the asparagine-linked carbohydrate residues of recombinant human follicle stimulating hormone in receptor binding and signal transduction, Mol Endocrinol, vol.8, pp.722-753, 1994. ,
Role of glycosylation in function of follicle-stimulating hormone, Endocrine, vol.11, pp.205-221, 1999. ,
Mapping the folliclestimulating hormone-induced signaling networks, Front Endocrinol, vol.2, p.45, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-01129612
FSHR polymorphism p.N680S mediates different responses to FSH in vitro, Mol Cell Endocrinol, vol.393, pp.83-91, 2014. ,
Specificity of the cyclic adenosine 3' ,5'-monophosphate signal in granulosa cell function, Biol Reprod, vol.67, pp.1653-61, 2002. ,
FSH signaling pathways in immature granulosa cells that regulate target gene expression: branching out from protein kinase A, Cell Signal, vol.18, pp.1351-1360, 2006. ,
The ERK signaling cascade inhibits gonadotropin-stimulated steroidogenesis, J Biol Chem, vol.292, p.8847, 2017. ,
FSH receptor signaling: complexity of interactions and signal diversity, Endocrinology, vol.159, pp.3020-3055, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-02373566
Spare" luteinizing hormone receptors: facts and fiction, Trends Endocrinol Metab, vol.29, pp.208-225, 2018. ,
Follitropin (FSH) and a phorbol ester stimulate the phosphorylation of the FSH receptor in intact cells, J Biol Chem, vol.269, pp.8772-8781, 1994. ,
Heterotrimetric Gi/o proteins control cyclic AMP oscillations and cytoskeletal structure assembly in primary human granulosa-lutein cells, Cell Signal, vol.11, pp.415-448, 1999. ,
Assessing gonadotropin receptor function by resonance energy transfer-based assays, Front Endocrinol, vol.6, p.130, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-01422312
Inhibition of rat granulosa cell differentiation by overexpression of G?q, Endocrine, vol.33, pp.21-31, 2008. ,
APPL1, APPL2, Akt2 and FOXO1a interact with FSHR in a potential signaling complex, Mol Cell Endocrinol, pp.260-262, 2007. ,
A novel folliclestimulating hormone-induced G alpha h/phospholipase C-delta1 signaling pathway mediating rat sertoli cell Ca2+-influx, Mol Endocrinol, vol.20, pp.2514-2541, 2006. ,
Dual coupling and down regulation of human FSH receptor in CHO cells, Life Sci, vol.60, pp.2043-50, 1997. ,
A phosphorylation cluster of five serine and threonine residues in the C-terminus of the follicle-stimulating hormone receptor is important for desensitization but not for beta-arrestin-mediated ERK activation, Mol Endocrinol, vol.20, pp.3014-3040, 2006. ,
Molecular mechanism of ?-arrestinbiased agonism at seven-transmembrane receptors, Annu Rev Pharmacol Toxicol, vol.52, pp.179-97, 2012. ,
Dynamic changes in glycosylation and glycan composition of serum FSH and LH during natural ovarian stimulation, Ups J Med Sci, vol.118, pp.153-64, 2013. ,
Naturally occurring folliclestimulating hormone glycosylation variants, J Glycomics Lipidom, vol.04, p.117, 2014. ,
The follitropin receptor: matching structure and function, Mol Pharmacol, vol.90, pp.596-608, 2016. ,
Glycosylation effects on FSH-FSHR interaction dynamics: a case study of different FSH glycoforms by molecular dynamics simulations, PLoS ONE, vol.10, p.137897, 2015. ,
Hypoglycosylated hFSH has greater bioactivity than fully glycosylated recombinant hFSH in human granulosa cells, J Clin Endocrinol Metab, vol.100, 2015. ,
Intracellular functions of N-linked glycans, Science, vol.291, pp.2364-2373, 2001. ,
Impact of carbohydrate heterogeneity in function of follicle-stimulating hormone: studies derived from in vitro and in vivo models, Biol Reprod, vol.69, pp.379-89, 2003. ,
Glycoform composition of serum gonadotrophins through the normal menstrual cycle and in the post-menopausal state, Mol Hum Reprod, vol.4, pp.631-640, 1998. ,
Qualitative difference in follicle-stimulating hormone activity in the pituitaries of young women compared to that of men and elderly women, J Clin Endocrinol Metab, vol.56, pp.371-376, 1983. ,
Biosimilar FSH preparations-are they identical twins or just siblings?, Reprod Biol Endocrinol, vol.14, p.32, 2016. ,
Biosimilars: opportunity or cause for concern?, J Pharm Pharm Sci, vol.10, pp.405-415, 2007. ,
Biosimilar recombinant follicle stimulating hormones in infertility treatment, Expert Opin Biol Ther, vol.14, pp.1399-409, 2014. ,
A comparison of the efficacy and tolerability of two recombinant human follicle-stimulating hormone preparations in patients undergoing in vitro fertilization-embryo transfer, Fertil Steril, vol.73, pp.114-120, 2000. ,
Clinical applications of gonadotropins in the female: assisted reproduction and beyond, Prog Mol Biol Transl Sci, vol.143, pp.85-119, 2016. ,
In-vivo biological activity and glycosylation analysis of a biosimilar recombinant human follicle-stimulating hormone product (Bemfola) compared with its reference medicinal product (GONAL-f), PLoS ONE, vol.12, p.184139, 2017. ,
Characterization of human FSH isoforms reveals a nonglycosylated ?-subunit in addition to the conventional glycosylated ?-subunit, J Clin Endocrinol Metab, vol.86, pp.3675-85, 2001. ,
Assay of the follicle stimulating hormone based on the augmentation with human chorionic gonadotropin, Endocrinology, vol.53, pp.604-620, 1953. ,
Disulfide-bond cleavage and formation in proteins, Science, vol.150, pp.1595-1603, 1965. ,
Silver staining of proteins in polyacrylamide gels, Nat Protoc, vol.1, pp.1852-1860, 2006. ,
URL : https://hal.archives-ouvertes.fr/hal-00158703
Heterogeneous hCG and hMG commercial preparations result in different intracellular signalling but induce a similar long-term progesterone response in vitro, Mol Hum Reprod, vol.23, pp.685-97, 2017. ,
Mammalian-like nonsialyl complex-type N-glycosylation of equine gonadotropins in Mimic TM insect cells, Glycobiology, vol.15, pp.776-90, 2005. ,
Antigenic determinants on human choriogonadotropin alpha-subunit. I. Characterization of topographic sites recognized by monoclonal antibodies, J Biol Chem, vol.263, pp.10364-10373, 1988. ,
LH and hCG action on the same receptor results in quantitatively and qualitatively different intracellular signalling, PLoS ONE, vol.7, p.46682, 2012. ,
Follicle-stimulating hormone potentiates the steroidogenic activity of chorionic gonadotropin and the anti-apoptotic activity of luteinizing hormone in human granulosa-lutein cells in vitro, Mol Cell Endocrinol, vol.422, pp.103-117, 2016. ,
Effects of the FSH receptor gene polymorphism p.N680S on cAMP and steroid production in cultured primary human granulosa cells, Reprod Biomed Online, vol.23, pp.196-203, 2011. ,
Human luteinizing hormone and chorionic gonadotropin display biased agonism at the LH and LH/CG receptors. Sci Rep, vol.7, p.940, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01594546
Use of a cAMP BRET sensor to characterize a novel regulation of cAMP by the sphingosine 1-phosphate/G13 pathway, J Biol Chem, vol.282, pp.10576-84, 2007. ,
Calcium dependence of aequorin bioluminescence dissected by random mutagenesis, Proc Natl Acad Sci, vol.103, pp.9500-9505, 2006. ,
URL : https://hal.archives-ouvertes.fr/hal-00112319
Estrogen modulates specific life and death signals induced by LH and hCG in human primary granulosa cells in vitro, Int J Mol Sci, vol.18, p.926, 2017. ,
NIH Image to ImageJ: 25 years of image analysis, Nat Methods, vol.9, pp.671-676, 2012. ,
Human LH and hCG stimulate differently the early signalling pathways but result in equal testosterone synthesis in mouse Leydig cells in vitro, Reprod Biol Endocrinol, vol.15, 2017. ,
Analysis of relative gene expression data using realtime quantitative PCR and the 2-CT method, Methods, vol.25, pp.402-410, 2001. ,
Silver staining of SDS-polyacrylamide Gel, Methods Enzymol, vol.541, pp.169-76 ,
Carbohydrate binding properties of complex-type oligosaccharides on immobilized Datura stramonium lectin, J Biol Chem, vol.262, pp.1602-1609, 1987. ,
The elderberry (Sambucus nigra L.) bark lectin recognizes the Neu5Ac(alpha 2-6)Gal/GalNAc sequence, J Biol Chem, vol.262, pp.1596-601, 1987. ,
The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line, Nat Biotechnol, vol.29, pp.735-776, 2011. ,
The immobilized leukoagglutinin from the seeds of Maackia amurensis binds with high affinity to complex-type Asnlinked oligosaccharides containing terminal sialic acid-linked alpha-2,3 to penultimate galactose residues, J Biol Chem, vol.263, pp.4576-85, 1988. ,
Jacalin: a jackfruit (Artocarpus heterophyllus) seed-derived lectin of versatile applications in immunobiological research, J Immunol Methods, vol.212, pp.193-211, 1998. ,
The effect of a "bisecting" N-acetylglucosaminyl group on the binding of biantennary, complex oligosaccharides to concanavalin A, Phaseolus vulgaris erythroagglutinin (E-PHA), and Ricinus communis agglutinin (RCA-120) immobilized on agarose, Carbohydr Res, vol.149, pp.65-83, 1986. ,
Sugar-lectin interactions: how does wheat-germ agglutinin bind sialoglycoconjugates?, Eur J Biochem, vol.104, pp.147-53, 1980. ,
Hormonal characteristics of the human menstrual cycle throughout reproductive life, J Clin Invest, vol.55, pp.699-706, 1975. ,
Analysis of recombinant human follicle-stimulating hormone (FSH) by mass spectrometric approaches, Anal Bioanal Chem, vol.400, pp.2427-2465, 2011. ,
Genetic engineering of human FSH (Gonal-F), Hum Reprod Update, vol.2, pp.172-91, 1996. ,
Continued improvements in the quality and consistency of follitropin alfa, recombinant human FSH, Reprod Biomed Online, vol.10, issue.10, pp.60937-60943, 2005. ,
Batch-to-batch consistency of human-derived gonadotrophin preparations compared with recombinant preparations, Reprod Biomed Online, vol.10, issue.10, p.60819, 2005. ,
, EMA/65507/2013 rev.1. Assessment Report. Bemfola International non-Proprietary Name: Follitropin Alfa, pp.1-76, 2014.
A multi-centre phase 3 study comparing efficacy and safety of Bemfola( R ) versus Gonal-f( R ) in women undergoing ovarian stimulation for IVF, Reprod Biomed Online, vol.30, pp.504-517, 2015. ,
, Ovaleap International Non-Proprietary Name: Follitropin Alfa, pp.1-72, 2013.
Randomized, active-controlled, comparative phase 3 efficacy and safety equivalence trial of Ovaleap R (recombinant human follicle-stimulating hormone) in infertile women using assisted reproduction technology (ART), Reprod Biol Endocrinol, vol.14, p.1, 2016. ,
Three-dimensional structure of human follicle-stimulating hormone, Mol Endocrinol, vol.15, pp.378-89, 2001. ,
Lectin affinity high-performance liquid chromatography. Interactions of N-glycanase-released oligosaccharides with Ricinus communis agglutinin I and Ricinus communis agglutinin II, J Biol Chem, vol.262, pp.12030-12039, 1987. ,
Hormonal regulation of follicle-stimulating hormone glycosylation in males, Front Endocrinol, vol.10, p.17, 2019. ,
Structure of human follicle-stimulating hormone in complex with its receptor, Nature, vol.433, pp.269-277, 2005. ,
Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor, Proc Natl Acad Sci, vol.109, pp.12491-12497, 2012. ,
Profiling of FSHR negative allosteric modulators on LH/CGR reveals biased antagonism with implications in steroidogenesis, Mol Cell Endocrinol, vol.436, pp.10-22, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01409332
The role of kinetic context in apparent biased agonism at GPCRs, Nat Commun, vol.7, p.10842, 2016. ,
Dichlorodiphenylchloroethylene elevates cytosolic calcium concentrations and oscillations in primary cultures of human granulosa-lutein cells, Biol Reprod, vol.70, pp.1693-700, 2004. ,
Temporal reprogramming of calcium signalling via crosstalk of gonadotrophin receptors that associate as functionally asymmetric heteromers, Sci Rep, vol.8, p.2239, 2018. ,
Preferential ?-arrestin signalling at low receptor density revealed by functional characterization of the human FSH receptor A189 V mutation, Mol Cell Endocrinol, vol.331, pp.109-127, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-00639767
Dual signaling potential is common among Gs-coupled receptors and dependent on receptor density, Mol Pharmacol, vol.46, pp.460-469, 1994. ,
Comparison of pharmacokinetic and safety profiles between Bemfola( R ) and Gonal-f( R ) after subcutaneous application, Eur J Drug Metab Pharmacokinet, vol.41, pp.259-65, 2016. ,