The dopamine hypothesis of schizophrenia: version III -the final common pathway, Schizophr. Bull, vol.35, issue.3, pp.549-562, 2009. ,
Al-Nahhas A. Positron emission tomography in schizophrenia: a new perspective, J. Nucl. Med, vol.51, issue.4, pp.511-520, 2010. ,
Dopamine receptor mapping with PET imaging in Parkinson's disease, J. Neurol, vol.261, issue.12, pp.2251-2263, 2014. ,
Chronic exposure to dopamine agonists affects the integrity of striatal D2 receptors in Parkinson's patients, Neuroimage Clin, vol.16, pp.455-460, 2017. ,
The role of dopamine in symptoms and treatment of apathy in Alzheimer's disease, CNS Neurosci. Ther, vol.17, issue.5, pp.411-427, 2011. ,
Parkinson's disease: mechanisms and models, Neuron, vol.39, issue.6, pp.889-909, 2003. ,
Functional differences between direct and indirect striatal output pathways in Huntington's disease, J. Huntingtons Dis, vol.1, issue.1, pp.17-25, 2012. ,
Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity, Neuropharmacology, vol.76, pp.498-509, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-02631577
Effectiveness of antipsychotic drugs in patients with chronic schizophrenia, N. Engl. J. Med, vol.353, issue.12, pp.1209-1223, 2005. ,
New concepts in dopamine D2 receptor biased signaling and implications for schizophrenia therapy, Biol. Psychiatry, vol.81, issue.1, pp.78-85, 2017. ,
Oligomerization of G-protein-coupled transmitter receptors, Nat. Rev. Neurosci, vol.2, issue.4, pp.274-286, 2001. ,
Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity, Science, vol.288, issue.5463, pp.154-157, 2000. ,
Dopamine D2 receptor dimers and receptor-blocking peptides, Biochem. Biophys. Res. Commun, vol.227, issue.1, pp.200-204, 1996. ,
Extreme vetting of dopamine receptor oligomerization. G-Protein-Coupled Receptor Dimers, pp.99-127, 2017. ,
The role of the D(2) dopamine receptor (D(2)R) in A(2A) adenosine receptor (A(2A)R)-mediated behavioral and cellular responses as revealed by A(2A) and D(2) receptor knockout mice, Proc. Natl Acad. Sci. USA, vol.98, issue.4, pp.1970-1975, 2001. ,
Allosteric mechanisms within the adenosine A2A-dopamine D2 receptor heterotetramer, Neuropharmacology, vol.104, pp.154-160, 2016. ,
Proposes a model for the functional properties of adenosine A2A receptor -dopamine D2 receptor oligomers and provides evidence regarding their physiological relevance ,
Evidence for the heterotetrameric structure of the adenosine A2A-dopamine D2 receptor complex, Biochem. Soc. Trans, vol.44, issue.2, pp.595-600, 2016. ,
Adenosine A2A-dopamine D2 receptor-receptor heteromerization: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer, J. Biol. Chem, vol.278, issue.47, pp.46741-46749, 2003. ,
Adenosine A2A agonist CGS 21680 decreases the affinity of dopamine D2 receptors for dopamine in human striatum, Neuroreport, vol.12, issue.9, pp.1831-1834, 2001. ,
Potential therapeutic interest of adenosine A2A receptors in psychiatric disorders, Curr. Pharm. Des, vol.14, issue.15, pp.1512-1524, 2008. ,
URL : https://hal.archives-ouvertes.fr/hal-02185493
Moonlighting proteins and protein-protein interactions as neurotherapeutic targets in the G protein-coupled receptor field, Neuropsychopharmacology, vol.39, issue.1, pp.131-155, 2014. ,
CrossTalk opposing view ,
G protein-coupled receptor multimers: A question still open despite the use of novel approaches, Mol. Pharmacol, vol.88, issue.3, pp.561-571, 2015. ,
GPCR monomers and oligomers: it takes all kinds, Trends Neurosci, vol.31, issue.2, pp.74-81, 2008. ,
Time-resolved FRET between GPCR ligands reveals oligomers in native tissues, Nat. Chem. Biol, vol.6, issue.8, pp.587-594, 2010. ,
A RhoA-FRET biosensor mouse for intravital imaging in normal tissue homeostasis and disease contexts, Cell Rep, vol.21, issue.1, pp.274-288, 2017. ,
In situ proximity ligation assay to study and understand the distribution and balance of GPCR homo-and heteroreceptor complexes in the brain. Receptor and Ion Channel Detection in the Brain: Methods and Protocols, vol.109, p.124, 2016. ,
Detection of antigen interactions ex vivo by proximity ligation assay: endogenous dopamine D2-adenosine A2A receptor complexes in the striatum, BioTechniques, vol.51, issue.2, pp.111-118, 2011. ,
URL : https://hal.archives-ouvertes.fr/inserm-02767955
First study to apply PLA on fixed brain tissue and to provide in situ evidence for the existence of D2R-A2AR complexes in the mouse brain ,
Cocaine self-administration specifically increases A2AR-D2R and D2R-sigma1R heteroreceptor complexes in the rat nucleus accumbens shell. Relevance for cocaine use disorder, Pharmacol. Biochem. Behav, vol.155, pp.24-31, 2017. ,
Protein detection using proximity-dependent DNA ligation assays, Nat. Biotechnol, vol.20, issue.5, pp.473-477, 2002. ,
, ? Seminal study that describes the use and validity of proximity ligation assay
Direct observation of individual endogenous protein complexes in situ by proximity ligation, Nat. Methods, vol.3, issue.12, pp.995-1000, 2006. ,
Cytokine detection by antibody-based proximity ligation, Proc. Natl Acad. Sci. USA, vol.101, issue.22, pp.8420-8424, 2004. ,
, ? First paper demonstrating the feasibility of antibody-based proximity ligation assay
Evidence for limited D1 and D2 receptor coexpression and colocalization within the dorsal striatum of the neonatal mouse, J. Comp. Neurol, vol.523, issue.8, pp.1175-1189, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-02635692
Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson's disease brain, Brain, vol.138, issue.6, pp.1642-1657, 2015. ,
Identification and description of three families with familial Alzheimer disease that segregate variants in the SORL1 gene, Acta. Neuropathol. Commun, vol.5, issue.1, p.43, 2017. ,
Evidence against dopamine D1/D2 receptor heteromers, Mol. Psychiatry, vol.20, issue.11, pp.1373-1385, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-02636137
The efficiency of systematic sampling in stereology-reconsidered, J. Microsc, vol.193, pp.199-211, 1999. ,
URL : https://hal.archives-ouvertes.fr/hal-02699243
, Bayesian Optimized PLA Signal Sorting (BOPSS, 2019.
Brain Tumor Detection Using Color-Based K-Means Clustering Segmentation, Third International Conference on Intelligent Information Hiding and Multimedia Signal Processing, vol.2, pp.245-250, 2007. ,
Improved methods for fluorescence microscopy detection of macromolecules at the axon initial segment, Front. Cell. Neurosci, vol.10, p.5, 2016. ,
Postmortem changes in the neuroanatomical characteristics of the primate brain: hippocampal formation, J. Comp. Neurol, vol.512, issue.1, pp.27-51, 2009. ,
The search for an optimal DNA, RNA, and protein detection by in situ hybridization, immunohistochemistry, and solution-based methods, Methods, vol.52, issue.4, pp.281-286, 2010. ,
The authors systematically compared nine fixation methods for their ability to preserve cell morphology and DNA/RNA/protein quality for histological applications ,
Visualizing G protein-coupled receptor-receptor interactions in brain using proximity ligation in situ assay, Curr. Protoc. Cell Biol, vol.67, issue.1, pp.17-17, 2015. ,
Hallucinogenic 5-HT2AR agonists LSD and DOI enhance dopamine D2R protomer recognition and signaling of D2-5-HT2A heteroreceptor complexes, Biochem. Biophys. Res. Commun, vol.443, issue.1, pp.278-284, 2014. ,
Characterizing and diminishing autofluorescence in formalin-fixed paraffin-embedded human respiratory tissue, J. Histochem. Cytochem, vol.62, issue.6, pp.405-423, 2014. ,
Fiji: an open-source platform for biological-image analysis, Nat. Methods, vol.9, issue.7, pp.676-682, 2012. ,
URL : https://hal.archives-ouvertes.fr/pasteur-02616466
Icy: an open bioimage informatics platform for extended reproducible research, Nat. Methods, vol.9, issue.7, pp.690-696, 2012. ,