This PD describes the concepts developed by WP6 to calculate complex indicators with up scaling procedures of APES and FSSIM model outputs from the farm-type level to the regional level. The description of upscaling procedures should be taken as a first proposal and preliminary reflections of WP6 on the broader subject of upscalling to be further studied inside WP1. These propositions take into account the conclusions of the third SEAMLESS symposium' workshops dedicated to this issue (i.e. upscaling) organized jointly by WP6 and WP1 (see conclusion on the SEAMLESS portal). The final procedures have to be defined in collaboration with WP1, WP2, WP3(particularly with T3.6 _EXPAMOD_ and T3.7_downscaling_) and WP4. The concepts have been used to design a list of indicators (referenced as the blue list). These indicators are going to be calculated with the Prototype 2 of SEAMLESS-IF. They have been selected using the following criteria: o Usefulness for the users in the context of a policy impact assessment. They were selected among the list of indicators used for Activity A6.2.1, so that they cover all the dimensions of the Goal Oriented Framework (GOF)designed by WP2 (Alkan Olsson et al., 2006). o They allow to explore the different calculation procedures involved in SEAMLESS-IF for the assessment of the indicators at macro (EU and Member States) and meso levels (NUT2 level or infra). Indeed, FSSIM model outputs are provided at the farm-type level and additional calculations are required to assess these indicators at the regional or higher levels. These calculations use several procedures, including various typologies and the blue-list indicators have been chosen to explore this variety of procedures. o Data required for their calculation are likely to be available from databases,farm typologies and model outputs (APES and FSSIM) in Prototype 2. In each sample region defined for the testing of the second prototype of SEAMLESS-IF, we will select a sub-sample of indicators from this list to be calculated for the baseline and policy scenarios described in D6233. Results of these calculations will be used to define with WP5 how to adapt the Indicator Manager to include these complex indicators in the third prototype. This PD describes first the concepts that WP6 proposes to develop for the calculation of complex indicators at the region (NUT2)level, with indicators that are the result of upscaling from AEnZ1 or farm level to the region level: Section 2 starts with a brief description of the scale changes that we address, summarizes the main characteristics of the indicators in SEAMLESS-IF, and then proposes aggregation procedures from the AEnZs to the region level into detailed regions. Section 3 illustrates these concepts and proposes a list of indicators that covers the various dimensions of the Goal Oriented Framework2 and the range of previously described aggregation possibilities. The PD ends with the proposal of calculation procedures to implement the complex indicators from this list in Prototype 2 and with the design of interpolation procedures from the sample regions to the EU level.