A full-scale membrane bioreactor (1600 m3.d-1) was monitored for modelling purposes during the summer 2006. A calibration of the ASM1 model is presented; the wastewater characterisation, the aeration and the biomass kinetics were principally investigated. Total BOD tests were not able to correctly estimate the biodegradable part of the wastewater entering the bioreactor, but by adjusting simulation results to the measured sludge production, the wastewater fractionation was identified and MLVSS accurately predicted. However, MLSS could not be correctly simulated as the consumption and production of mineral suspended solids is not considered by the model. The membranes are immerged in the aeration tank leading to several combinations of coarse bubble and fine bubbles systems, running alone or together (five different configurations). The oxygen transfer rates estimated in a previous work were inserted in the model and the comparison of the simulated oxygen concentrations with the two sensors signals were satisfying considering the very low DO concentrations (0.6mgO2.L-1 on average). The biomass kinetics were studied using maximum nitrification rates and an 8-hour calibration campaign of intensive sampling. A new set of parameters for ASM1 (heterotrophic and autotrophic biomass kinetics and half saturation coefficients) was identified and a common anoxic value for the heterotrophic growth yield (YH, anoxic) was adopted. Despite simultaneous nitrification and denitrification in the aeration tank, the results of the calibrated model showed good agreement with the measured NH4+-N and NO3--N outlets.