To fulfil the objectives of the ClimAware project, the following modelling methodology was implemented. Starting from a European modelling approach of water availability and use based on the WaterGAP3 model, the changes in the hydrologic regimes and water use of different sectors were analysed. Subsequently three case studies were used to investigate the impacts of CC at a regional scale. Regional models from three different countries and focusing on three types of water management issues were developed: • Hydromorphology (Eder basin, Germany): By using different scenarios, the influence of CC on the hydromorphological characteristics of the River Weser according to the WFD was evaluated and proposals for implementation were given. The objective was to examine, on typical river sections, how the WFD objectives can be implemented under CC constraints. • Dam management (Seine basin, France): Water management on the River Seine for water supply and flood alleviation is partly based on the management of artificial reservoirs. The case study developed scenarios linking the impact of CC on water resources and the expected change on the uses and on the management of the system. • Agricultural water use (Apulia region, Italy): In this region, economic and demographic changes cause an increase in the demand for good-quality municipal and industrial water. Besides, changes in the agricultural practices increase the demand for water in the agricultural sector. Since water is scarce in this region, the study focuses on the agricultural sector, which has the largest water saving potential. The final assessment comprises a cross-scale integration between the European and regional modelling frameworks in order to facilitate knowledge transfer and to help establishing sustainable and integrated water resources management plans.