The electrodes used in our analyzes are electrodes based on microcrystalline boron-doped diamond (BDD), micromachined by femtosecond laser. The electrochemical performance of the new BDD microelectrodes were first evaluated by the method of differential pulse anodic stripping voltammetric (DPASV) for the simultaneous determination at nanomolar level of four heavy metal ions in water: Cd (II), Ni (II), Pb (II), Hg (II) and then by square wave voltammetric method (SWV) for the determination of uranium. With these approaches are obtained low detection limits 0.4, 6.8, 5.5, and 2.3 nM, respectively for Cd (II), Ni (II) Pb (II) and Hg (II) and 0.5 mg L"' for uranium, less than that of the other sensors described in the literature.