S. L. Andersen, Frequency and outcomes of maternal thyroid function abnormalities in 753 early pregnancy, Scandinavian Journal of Clinical and Laboratory Investigation, vol.79, pp.99-754, 2019.

M. T. Aung, L. E. Johns, K. K. Ferguson, B. Mukherjee, T. F. Mcelrath et al., Thyroid 756 hormone parameters during pregnancy in relation to urinary bisphenol A 757 concentrations: A repeated measures study, Environment International, vol.104, pp.33-40, 2017.

,

S. A. Back and A. R. Hohimer, Prenatal Determinants of Brain Development: Recent Studies and 760, 2016.

, Prenatal and Postnatal Determinants of 761 Development, Methodological Advances, pp.303-326

,

J. S. Barry and R. V. Anthony, The pregnant sheep as a model for human pregnancy, 2008.

, Theriogenology, vol.69, pp.55-67

M. Bellanger, B. Demeneix, P. Grandjean, R. T. Zoeller, and L. Trasande, Neurobehavioral 766 deficits, diseases, and associated costs of exposure to endocrine-disrupting chemicals in 767 the European Union, J. Clin. Endocrinol. Metab, vol.100, pp.1256-1266, 2015.

M. Bellingham, M. R. Amezaga, B. Mandon-pepin, C. J. Speers, C. E. Kyle et al., , p.770

R. M. Cotinot, C. Rhind, S. M. Fowler, and P. A. , Exposure to chemical cocktails before or 771 after conception---the effect of timing on ovarian development, Mol. Cell. Endocrinol, vol.772, pp.156-172, 2013.

M. Bellingham, P. A. Fowler, M. R. Amezaga, S. M. Rhind, C. Cotinot et al., Exposure to a complex cocktail of environmental endocrine-775 disrupting compounds disturbs the kisspeptin/GPR54 system in ovine hypothalamus 776 and pituitary gland, Environ. Health Perspect, vol.117, pp.1556-1562, 2009.

M. Bellingham, P. A. Fowler, M. R. Amezaga, C. M. Whitelaw, S. M. Rhind et al., , p.779

B. Pepin, R. M. Sharpe, and N. P. Evans, Foetal hypothalamic and pituitary expression of 780 gonadotrophin-releasing hormone and galanin systems is disturbed by exposure to 781 sewage sludge chemicals via maternal ingestion, J. Neuroendocrinol, vol.22, pp.527-533, 2010.

,

M. Bellingham, P. A. Fowler, E. S. Macdonald, B. Mandon-pepin, C. Cotinot et al., Timing of Maternal Exposure and Foetal Sex Determine the 785 Effects of Low-level Chemical Mixture Exposure on the Foetal Neuroendocrine System in 786 Sheep, J. Neuroendocrinol, vol.28, 2016.

M. Bellingham, C. Mckinnell, P. A. Fowler, M. R. Amezaga, Z. Zhang et al., , p.788

B. Mandon-pepin, N. P. Evans, and R. M. Sharpe, Foetal and post-natal exposure of 789 sheep to sewage sludge chemicals disrupts sperm production in adulthood in a subset of 790 animals, Int. J. Androl, vol.35, pp.317-329, 2012.

V. S. Bhat, J. L. Durham, G. L. Ball, and J. C. English, Derivation of an Oral Reference Dose (RfD) 792 for the Nonphthalate Alternative Plasticizer 1,2-Cyclohexane Dicarboxylic Acid, 2014.

, Journal of Toxicology and Environmental Health, Part B, vol.17, pp.63-794

, Comment citer ce document

C. Viguié, E. Chaillou, V. Gayrard, N. Picard-hagen, and P. A. Fowler, Toward a better understanding of the effects of endocrine disrupting compounds on health: Human-relevant case studies from sheep models, Molecular and Cellular Endocrinology, vol.505, 2020.

J. G. Boucher, A. Boudreau, S. Ahmed, and E. Atlas, Vitro Effects of Bisphenol A ?, p.796, 2015.

. Glucuronide, BPA-G) on Adipogenesis in Human and Murine Preadipocytes

, Environmental Health Perspectives, vol.123, pp.1287-1293

,

B. Burchell, M. Coughtrie, M. Jackson, D. Harding, S. Fournel-gigleux et al., 800 Development of human liver UDP-glucuronosyltransferases, Dev Pharmacol Ther, vol.13, pp.70-801, 1989.

L. Caporossi and B. Papaleo, Bisphenol A and Metabolic Diseases: Challenges for Occupational 803, Medicine. International Journal of Environmental Research and Public Health, vol.14, 2017.

M. C. Catanese, A. Suvorov, and L. N. Vandenberg, Beyond a means of exposure: a new view of 806 the mother in toxicology research, Toxicol. Res, vol.4, pp.592-612, 2015.

J. Chevrier, R. B. Gunier, A. Bradman, N. T. Holland, A. M. Calafat et al., 809 Maternal urinary bisphenol a during pregnancy and maternal and neonatal thyroid 810 function in the CHAMACOS study, Environ. Health Perspect, vol.121, pp.138-144, 2013.

J. A. Clavero, J. Negueruela, L. Ortiz, J. A. De-los-heros, and S. P. Modrego, Blood flow in the 813 intervillous space and fetal blood flow. I. Normal values, 1973.

, Am. J. Obstet. Gynecol, vol.116, pp.31291-31297

T. Corbel, V. Gayrard, S. Puel, M. Z. Lacroix, A. Berrebi et al.,

N. Hagen, Bidirectional placental transfer of Bisphenol A and its main metabolite, p.817, 2014.

. Bisphenol-a-glucuronide, the isolated perfused human placenta. Reproductive 818 Toxicology, vol.47, pp.51-58

T. Corbel, V. Gayrard, C. Viguié, S. Puel, M. Z. Lacroix et al., , p.820, 2013.

, Bisphenol A disposition in the sheep maternal-placental-fetal unit: mechanisms 821 determining fetal internal exposure, Biol. Reprod, vol.89

T. Corbel, E. Perdu, V. Gayrard, S. Puel, M. Z. Lacroix et al.,

N. Hagen, Conjugation and deconjugation reactions within the fetoplacental 825 compartment in a sheep model: a key factor determining bisphenol A fetal exposure, 2015.

, Drug Metab. Dispos, vol.43, pp.467-476

E. Cuevas, E. Ausó, M. Telefont, G. Morreale-de-escobar, C. Sotelo et al., Transient 828 maternal hypothyroxinemia at onset of corticogenesis alters tangential migration of 829 medial ganglionic eminence-derived neurons, Eur. J. Neurosci, vol.22, pp.541-551, 2005.

,

W. Dekant and W. Völkel, Human exposure to bisphenol A by biomonitoring: methods, results 832 and assessment of environmental exposures, Toxicol. Appl. Pharmacol, vol.228, pp.114-134, 2008.

,

A. Dutour, N. Briard, V. Guillaume, E. Magnan, M. Cataldi et al., Another 835 view of GH neuroregulation: lessons from the sheep, Eur. J. Endocrinol, vol.136, pp.553-565, 1997.

D. I. Edelstone, A. M. Rudolph, and M. A. Heymann, Liver and ductus venosus blood flows in 838 fetal lambs in utero, Circ. Res, vol.42, pp.426-433, 1978.

, Scientific opinion on the risks to public health related to the presence of bisphenol A 840 (BPA) in foodstuffs, EFSA Journal, vol.3978, 2015.

H. W. Erhard and S. M. Rhind, Prenatal and postnatal exposure to environmental pollutants in 842 sewage sludge alters emotional reactivity and exploratory behaviour in sheep, Sci. Total 843 Environ, vol.332, pp.101-108, 2004.

N. Andersson, M. Arena, and D. Auteri, European Chemical Agency (ECHA) and European Food Safety Authority (EFSA) with the 845 technical support of the Joint Research Centre (JRC), p.846

S. Barmaz, E. Grignard, A. Kienzler, P. Lepper, A. M. Lostia et al., , p.847

F. Pellizzato, J. Tarazona, A. Terron, and S. Van-der-linden, Guidance for the 848 Comment citer ce document, 2018.

C. Viguié, E. Chaillou, V. Gayrard, N. Picard-hagen, and P. A. Fowler, Toward a better understanding of the effects of endocrine disrupting compounds on health: Human-relevant case studies from sheep models, Molecular and Cellular Endocrinology, vol.505, 2020.

, Conclusion regarding the peer review of the 851 pesticide risk assessment of the active substance fipronil: Conclusion regarding the peer 852 review of the pesticide risk assessment of the active substance fipronil, European Food Safety Authority (EFSA), vol.4, 2006.

N. P. Evans, M. Bellingham, and J. E. Robinson, Prenatal programming of neuroendocrine 855 reproductive function, Theriogenology, vol.86, pp.340-348, 2016.

,

N. P. Evans, M. Bellingham, R. M. Sharpe, C. Cotinot, S. M. Rhind et al.,

S. Klonisch, P. M. Lind, and P. A. Fowler, Reproduction Symposium: does grazing on 859 biosolids-treated pasture pose a pathophysiological risk associated with increased 860 exposure to endocrine disrupting compounds?, J. Anim. Sci, vol.92, pp.3185-3198, 2014.

J. J. Faber and T. J. Green, Foetal placental blood flow in the lamb, J. Physiol. (Lond.), vol.223, pp.375-863, 1972.

P. Filis, S. Hombach-klonisch, P. Ayotte, N. Nagrath, U. Soffientini et al., Maternal smoking and high BMI disrupt thyroid gland 866 development, BMC Medicine, vol.16, 2018.

P. Filis, N. Walker, L. Robertson, E. Eaton-turner, L. Ramona et al., , p.868

Z. Zhang, B. Mandon-pepin, N. P. Evans, R. M. Sharpe, C. Cotinot et al., , p.869

P. O'shaughnessy and P. A. Fowler, Long-term exposure to chemicals in sewage sludge 870 fertilizer alters liver lipid content in females and cancer marker expression in males, 2019.

, Environ Int, vol.124, pp.98-108

D. A. Fisher, Thyroid system ontogeny in the sheep: a model for precocial mammalian 873 species, Adv. Exp. Med. Biol, vol.299, pp.11-26, 1991.

D. A. Fisher, J. H. Dussault, J. Sack, and I. J. Chopra, Ontogenesis of hypothalamic--pituitary--875 thyroid function and metabolism in man, sheep, and rat, Recent Prog. Horm. Res, vol.33, pp.59-876, 1976.

P. A. Fowler, M. Bellingham, K. D. Sinclair, N. P. Evans, P. Pocar et al., , vol.878

J. Schmidt, M. R. Amezaga, S. Bhattacharya, S. M. Rhind, and P. J. O'shaughnessy, 879 Impact of endocrine-disrupting compounds (EDCs) on female reproductive health, 2012.

, Cell. Endocrinol, vol.355, pp.231-239

P. A. Fowler, N. J. Dorà, H. Mcferran, M. R. Amezaga, D. W. Miller et al., , p.882

N. P. Evans, C. Cotinot, R. M. Sharpe, and S. M. Rhind, In utero exposure to low doses of 883 environmental pollutants disrupts fetal ovarian development in sheep, 2008.

. Reprod, , vol.14, pp.269-280

A. Garmendia-madariaga, S. Santos-palacios, F. Guillén-grima, and J. C. Galofré, The Incidence 886 and Prevalence of Thyroid Dysfunction in Europe: A Meta-Analysis, Clinical Endocrinology & Metabolism, vol.887, pp.923-931, 2014.

G. Gauderat, N. Picard-hagen, P. Toutain, T. Corbel, C. Viguié et al., , p.890

P. Mindeguia, A. Bousquet-melou, and V. Gayrard, Bisphenol A glucuronide 891 deconjugation is a determining factor of fetal exposure to bisphenol A, Environ Int, vol.86, pp.52-59, 2016.

G. Gauderat, N. Picard-hagen, P. Toutain, R. Servien, C. Viguié et al., Prediction of human prenatal exposure to 895 bisphenol A and bisphenol A glucuronide from an ovine semi-physiological toxicokinetic 896 model, Sci Rep, vol.7, 2017.

R. R. Gerona, T. J. Woodruff, C. A. Dickenson, J. Pan, J. M. Schwartz et al., , p.898

V. Y. Fujimoto and P. A. Hunt, Bisphenol-A (BPA), BPA glucuronide, and BPA sulfate in 899 midgestation umbilical cord serum in a northern and central California population, 2013.

, Environ. Sci. Technol, vol.47, pp.12477-12485

, Comment citer ce document

C. Viguié, E. Chaillou, V. Gayrard, N. Picard-hagen, and P. A. Fowler, Toward a better understanding of the effects of endocrine disrupting compounds on health: Human-relevant case studies from sheep models, Molecular and Cellular Endocrinology, vol.505, 2020.

A. Ghassabian, H. El-marroun, R. P. Peeters, V. W. Jaddoe, A. Hofman et al., , p.902

T. White, Downstream Effects of Maternal Hypothyroxinemia in Early Pregnancy: 903 Nonverbal IQ and Brain Morphology in School-Age Children, The Journal of Clinical 904 Endocrinology & Metabolism, vol.99, pp.2383-2390, 2014.

G. G. Gibson, N. J. Plant, K. E. Swales, A. Ayrton, and W. El-sankary, Receptor-dependent 906 transcriptional activation of cytochrome P4503A genes: induction mechanisms, species 907 differences and interindividual variation in man, Xenobiotica, vol.32, pp.165-206, 2002.

M. E. Gilbert, J. H. Goodman, J. Gomez, A. F. Johnstone, and R. L. Ramos, Adult hippocampal 910 neurogenesis is impaired by transient and moderate developmental thyroid hormone 911 disruption, Neurotoxicology, vol.59, pp.9-21, 2017.

M. E. Gilbert and S. M. Lasley, Developmental thyroid hormone insufficiency and brain 913 development: a role for brain-derived neurotrophic factor (BDNF)?, Neuroscience, vol.239, pp.253-270, 2013.

M. E. Gilbert, R. L. Ramos, D. P. Mccloskey, and J. H. Goodman, Subcortical Band Heterotopia in 916 Rat Offspring Following Maternal Hypothyroxinaemia: Structural and Functional 917 Characteristics, Journal of Neuroendocrinology, vol.26, pp.528-541, 2014.

M. E. Gilbert, J. Rovet, Z. Chen, and N. Koibuchi, Developmental thyroid hormone disruption: 920 Prevalence, environmental contaminants and neurodevelopmental consequences, 921 NeuroToxicology, vol.33, pp.842-852, 2012.

M. E. Gilbert, J. Rovet, Z. Chen, and N. Koibuchi, Developmental thyroid hormone disruption: 923 Prevalence, environmental contaminants and neurodevelopmental consequences, 924 NeuroToxicology, vol.33, pp.842-852, 2012.

M. E. Gilbert and L. Sui, Dose-dependent reductions in spatial learning and synaptic function 926 in the dentate gyrus of adult rats following developmental thyroid hormone 927 insufficiency, Brain Res, vol.1069, pp.10-22, 2006.

F. C. Grandin, M. Z. Lacroix, V. Gayrard, G. Gauderat, H. Mila et al., Bisphenol S instead of Bisphenol A: Toxicokinetic investigations in the ovine 930 materno-feto-placental unit, Environ Int, vol.929, pp.584-592, 2018.

,

F. C. Grandin, M. Z. Lacroix, V. Gayrard, C. Viguié, H. Mila et al., , p.933

J. Corbett, C. Gayrard, C. A. Gely, P. Toutain, and N. Picard-hagen, Is bisphenol S a 934 safer alternative to bisphenol A in terms of potential fetal exposure ? Placental transfer 935 across the perfused human placenta, Chemosphere, vol.221, pp.471-478, 2019.

,

D. Guignard, V. Gayrard, M. Z. Lacroix, S. Puel, N. Picard-hagen et al., Evidence for 938 bisphenol A-induced disruption of maternal thyroid homeostasis in the pregnant ewe at 939 low level representative of human exposure, Chemosphere, vol.182, pp.458-467, 2017.

,

R. Habert, V. Muczynski, T. Grisin, D. Moison, S. Messiaen et al., , p.942

R. Lambrot, A. Lehraiki, T. N'tumba-byn, M. Guerquin, C. Levacher et al., , p.943

G. Livera, Concerns about the widespread use of rodent models for human risk 944 assessments of endocrine disruptors, Reproduction, vol.147, pp.119-129, 2014.

G. Haugen, T. Kiserud, K. Godfrey, S. Crozier, and M. Hanson, Portal and umbilical venous 947 blood supply to the liver in the human fetus near term, Ultrasound Obstet Gynecol, vol.24, pp.599-605, 2004.

J. Henrichs, A. Ghassabian, R. P. Peeters, and H. Tiemeier, Maternal hypothyroxinemia and 950 effects on cognitive functioning in childhood: how and why, Clinical Endocrinology, vol.79, pp.951-152, 2013.

S. Hombach-klonisch, A. Danescu, F. Begum, M. R. Amezaga, S. M. Rhind et al., , p.953

N. P. Bellingham, M. Cotinot, C. Mandon-pepin, B. Fowler, P. A. Klonisch et al., Peri-954 conceptional changes in maternal exposure to sewage sludge chemicals disturbs fetal 955 Comment citer ce document, 2013.

C. Viguié, E. Chaillou, V. Gayrard, N. Picard-hagen, and P. A. Fowler, Toward a better understanding of the effects of endocrine disrupting compounds on health: Human-relevant case studies from sheep models, Molecular and Cellular Endocrinology, vol.505, pp.98-108, 2020.

K. L. Howdeshell, A model of the development of the brain as a construct of the thyroid 958 system, Environmental Health Perspectives, vol.110, pp.337-348, 2002.

S. A. Jones, L. B. Moore, J. L. Shenk, G. B. Wisely, G. A. Hamilton et al., , p.961

E. L. Lecluyse, M. H. Lambert, T. M. Willson, S. A. Kliewer, and J. T. Moore, The Pregnane 962 X Receptor: A Promiscuous Xenobiotic Receptor That Has Diverged during Evolution, 2000.

, Molecular Endocrinology, vol.14, pp.27-39

F. J. Karsch and D. F. Battaglia, Mechanisms for endotoxin-induced disruption of ovarian 965 cyclicity: observations in sheep, Reprod. Suppl, vol.59, pp.101-113, 2002.

H. Kojima, S. Takeuchi, S. Sanoh, K. Okuda, S. Kitamura et al., Profiling of bisphenol A and eight of its analogues on transcriptional activity via 968 human nuclear receptors, Toxicology, vol.413, pp.48-55, 2019.

,

L. Kolatorova, J. Vitku, R. Hampl, K. Adamcova, T. Skodova et al., , p.971

M. Duskova, Exposure to bisphenols and parabens during pregnancy and relations 972 to steroid changes, Environmental Research, vol.163, pp.115-122, 2018.

,

X. C. Kretschmer and W. S. Baldwin, CAR and PXR: Xenosensors of endocrine disrupters? 975, Chemico-Biological Interactions, vol.155, pp.111-128, 2005.

,

S. Kumar, G. R. Tonn, E. Kwan, C. Hall, K. W. Riggs et al., Estimation of 978 transplacental and nonplacental diphenhydramine clearances in the fetal lamb: the 979 impact of fetal first-pass hepatic drug uptake, J. Pharmacol. Exp. Ther, vol.282, pp.617-632, 1997.

R. Kuruto-niwa, R. Nozawa, T. Miyakoshi, T. Shiozawa, and Y. Terao, Estrogenic activity of 981 alkylphenols, bisphenol S, and their chlorinated derivatives using a GFP expression 982 system, Environmental Toxicology and Pharmacology, vol.19, pp.121-130, 2005.

,

M. Larsson, T. Pettersson, and A. Carlström, Thyroid hormone binding in serum of 15 985 vertebrate species: isolation of thyroxine-binding globulin and prealbumin analogs, 1985.

, Comp. Endocrinol, vol.58, pp.360-375

L. Fol, V. Aït-aïssa, S. Cabaton, N. Dolo, L. Grimaldi et al., , p.988

F. Brion and D. Zalko, Cell-Specific Biotransformation of Benzophenone-2 and 989, 2015.

, Bisphenol-S in Zebrafish and Human in Vitro Models Used for Toxicity and Estrogenicity 990 Screening, Environ. Sci. Technol, vol.49, pp.3860-3868

R. G. Lea, M. R. Amezaga, B. Loup, B. Mandon-pépin, A. Stefansdottir et al., , p.992

C. Allen, L. Purdie, L. Jouneau, C. Cotinot, S. M. Rhind et al., 993 The fetal ovary exhibits temporal sensitivity to a "real-life" mixture of environmental 994 chemicals, Sci Rep, vol.6, 2016.

J. Leghait, V. Gayrard, N. Picard-hagen, M. Camp, E. Perdu et al., , 2009.

, Fipronil-induced disruption of thyroid function in rats is mediated by increased total and 997 free thyroxine clearances concomitantly to increased activity of hepatic enzymes, 998 Toxicology, vol.255, pp.38-44

J. Leghait, V. Gayrard, P. Toutain, N. Picard-hagen, and C. Viguié, Is the mechanisms of 1000 fipronil-induced thyroid disruption specific of the rat: Re-evaluation of fipronil thyroid 1001 toxicity in sheep?, Toxicology Letters, vol.194, pp.51-57, 2010.

,

R. Leiser, C. Krebs, B. Ebert, and V. Dantzer, Placental vascular corrosion cast studies: a 1004 comparison between ruminants and humans, Microsc. Res. Tech, vol.38, pp.76-87, 1997.

,

, Comment citer ce document

C. Viguié, E. Chaillou, V. Gayrard, N. Picard-hagen, and P. A. Fowler, Toward a better understanding of the effects of endocrine disrupting compounds on health: Human-relevant case studies from sheep models, Molecular and Cellular Endocrinology, vol.505, 2020.

C. Liao, F. Liu, and K. Kannan, Bisphenol S, a New Bisphenol Analogue, Paper Products and 1008, 2012.

, Currency Bills and Its Association with Bisphenol A Residues, Environ. Sci. Technol, vol.46, pp.6515-6522, 1009.

P. M. Lind, M. Gustafsson, S. A. Hermsen, S. Larsson, C. E. Kyle et al., Exposure to pastures fertilised with sewage sludge disrupts bone tissue homeostasis in 1012 sheep, Sci. Total Environ, vol.407, pp.2200-2208, 1011.

,

P. M. Lind, M. Gustafsson, S. A. Hermsen, S. Larsson, C. E. Kyle et al., 1015 Exposure to pastures fertilised with sewage sludge disrupts bone tissue homeostasis in 1016 sheep, Sci. Total Environ, vol.407, pp.2200-2208, 2009.

,

P. M. Lind, D. Oberg, S. Larsson, C. E. Kyle, J. Orberg et al., Pregnant ewes exposed 1019 to multiple endocrine disrupting pollutants through sewage sludge-fertilized pasture 1020 show an anti-estrogenic effect in their trabecular bone, Sci. Total Environ, vol.408, pp.2340-1021, 2010.

G. R. Marchesini, A. Meimaridou, W. Haasnoot, E. Meulenberg, F. Albertus et al., , p.1023

M. Takeuchi, H. Irth, and A. J. Murk, Biosensor discovery of thyroxine transport 1024 disrupting chemicals, Toxicology and Applied Pharmacology, vol.232, pp.150-160, 2008.

,

J. B. Matthews, K. Twomey, and T. R. Zacharewski, In vitro and in vivo interactions of 1027 bisphenol A and its metabolite, bisphenol A glucuronide, with estrogen receptors alpha 1028 and beta, Chem. Res. Toxicol, vol.14, pp.149-157, 2001.

C. M. Mendel, R. A. Weisiger, A. L. Jones, and R. R. Cavalieri, Thyroid hormone-binding proteins 1030 in plasma facilitate uniform distribution of thyroxine within tissues: a perfused rat liver 1031 study, Endocrinology, vol.120, pp.1742-1749, 1987.

G. Meschia, J. R. Cotter, C. S. Breathnach, and D. H. Barron, THE HEMOGLOBIN, OXYGEN, 1033 CARBON DIOXIDE AND HYDROGEN ION CONCENTRATIONS IN THE UMBILICAL BLOODS 1034 OF SHEEP AND GOATS AS SAMPLED VIA INDWELLING PLASTIC CATHETERS, J Exp 1035 Physiol Cogn Med Sci, vol.50, pp.185-195, 1965.

J. Molina-molina, E. Amaya, M. Grimaldi, J. Sáenz, M. Real et al., , p.1037

N. Olea, In vitro study on the agonistic and antagonistic activities of bisphenol-S 1038 and other bisphenol-A congeners and derivatives via nuclear receptors, Toxicology and 1039 Applied Pharmacology, vol.272, pp.127-136, 2013.

J. L. Morrison, M. J. Berry, K. J. Botting, J. R. Darby, M. G. Frasch et al., , p.1041

C. L. Gray, R. Harding, E. A. Herrera, M. W. Kemp, M. C. Lock et al., , p.1042

G. C. Musk, M. H. Oliver, T. R. Regnault, C. T. Roberts, J. Y. Soo et al., 1043 Improving pregnancy outcomes in humans through studies in sheep, American Journal of 1044 Physiology-Regulatory, Integrative and Comparative Physiology, vol.315, pp.1123-1153, 1045.

E. Mourier, A. Tarrade, J. Duan, C. Richard, C. Bertholdt et al., , p.1047

P. Palmer, Non-invasive evaluation of placental blood flow: lessons from animal 1048 models, Reproduction, vol.153, pp.85-96, 2017.

B. B. Mughal, J. Fini, and B. A. Demeneix, Thyroid-disrupting chemicals and brain 1050 development: an update, Endocrine Connections, vol.7, pp.160-186, 1051.

P. Ngamprasertwong, M. Dong, J. Niu, R. Venkatasubramanian, A. A. Vinks et al., Propofol Pharmacokinetics and Estimation of Fetal Propofol Exposure during Mid-1054 Gestational Fetal Surgery: A Maternal-Fetal Sheep Model, PLoS ONE, vol.11, 1053.

J. Oh, J. W. Choi, Y. Ahn, and S. Kim, Pharmacokinetics of bisphenol S in humans after single 1057 oral administration, Environment International, vol.112, pp.127-133, 2018.

,

T. A. Patterson, N. C. Twaddle, C. S. Roegge, R. J. Callicott, J. W. Fisher et al., 1060 Concurrent determination of bisphenol A pharmacokinetics in maternal and fetal rhesus 1061 Comment citer ce document, 2013.

C. Viguié, E. Chaillou, V. Gayrard, N. Picard-hagen, and P. A. Fowler, Toward a better understanding of the effects of endocrine disrupting compounds on health: Human-relevant case studies from sheep models, Molecular and Cellular Endocrinology, vol.505, pp.41-48, 1062.

C. Paul, S. M. Rhind, C. E. Kyle, H. Scott, C. Mckinnell et al., Cellular and hormonal 1064 disruption of fetal testis development in sheep reared on pasture treated with sewage 1065 sludge, Environ. Health Perspect, vol.113, pp.1580-1587, 2005.

D. H. Polk, A. Reviczky, R. W. Lam, and D. A. Fisher, Thyrotropin-releasing hormone in ovine 1067 fetus: ontogeny and effect of thyroid hormone, Am. J. Physiol, vol.260, pp.53-58, 1068.

M. Pretheeban, G. Hammond, S. Bandiera, W. Riggs, and D. Rurak, Ontogenesis of UDP-1070 glucuronosyltransferase enzymes in sheep, Comp. Biochem. Physiol., Part A Mol. Integr, p.1071, 2011.

, Physiol, vol.159, pp.159-166

M. Puttabyatappa, J. D. Martin, V. Andriessen, M. Stevenson, L. Zeng et al., , p.1073

V. Padmanabhan, Developmental programming: Changes in mediators of insulin 1074 sensitivity in prenatal bisphenol A-treated female sheep, Reprod. Toxicol, vol.85, pp.110-122, 1075.

S. Remaud, J. Gothiã©, G. Morvan-dubois, and B. A. Demeneix, Thyroid Hormone Signaling 1077 and Adult Neurogenesis in Mammals, Frontiers in Endocrinology, vol.5, 1078.

S. M. Rhind, N. P. Evans, M. Bellingham, R. M. Sharpe, C. Cotinot et al., , p.1080

K. D. Sinclair, R. G. Lea, P. Pocar, B. Fischer, E. Van-der-zalm et al., , p.1081

M. R. Amezaga and P. A. Fowler, Effects of environmental pollutants on the 1082 reproduction and welfare of ruminants, Animal, vol.4, pp.1227-1239, 1083.

S. M. Rhind, C. E. Kyle, C. Kerr, M. Osprey, and Z. L. Zhang, Effect of duration of exposure to 1085 sewage sludge-treated pastures on liver tissue accumulation of persistent endocrine 1086 disrupting compounds (EDCs) in sheep, Sci. Total Environ, vol.409, pp.3850-3856, 2011.

,

S. M. Rhind, C. E. Kyle, C. Mackie, and L. Mcdonald, Accumulation of endocrine disrupting 1089 compounds in sheep fetal and maternal liver tissue following exposure to pastures 1090 treated with sewage sludge, J Environ Monit, vol.11, pp.1469-1476, 1091.

S. M. Rhind, C. E. Kyle, C. Mackie, L. Mcdonald, Z. Zhang et al., , p.1093

M. R. Mandon-pepin, B. Loup, B. Cotinot, C. Evans, N. P. Sharpe et al., Maternal and fetal tissue accumulation of selected endocrine disrupting 1095 compounds (EDCs) following exposure to sewage sludge-treated pastures before or after 1096 conception, J Environ Monit, vol.12, pp.1582-1593, 10942010.

S. M. Rhind, C. E. Kyle, C. Mackie, and G. Telfer, Effects of exposure of ewes to sewage sludge-1098 treated pasture on phthalate and alkyl phenol concentrations in their milk. Sci. Total 1099 Environ, vol.383, pp.70-80, 2007.

S. M. Rhind, C. E. Kyle, C. Mackie, K. Yates, and E. I. Duff, Geographic variation in tissue 1101 accumulation of endocrine disrupting compounds (EDCs) in grazing sheep, 2011.

. Pollut, , vol.159, pp.416-422

S. M. Rhind, C. E. Kyle, H. Ruffie, E. Calmettes, M. Osprey et al., Short-and long-term temporal changes in soil concentrations of selected 1105 endocrine disrupting compounds (EDCs) following single or multiple applications of 1106 sewage sludge to pastures, Environ. Pollut, vol.181, pp.262-270, 1104.

,

S. M. Rhind, C. E. Kyle, G. Telfer, E. I. Duff, and A. Smith, Alkyl phenols and diethylhexyl 1109 phthalate in tissues of sheep grazing pastures fertilized with sewage sludge or inorganic 1110 fertilizer, Environ. Health Perspect, vol.113, pp.447-453, 2005.

S. M. Rhind, A. Smith, C. E. Kyle, G. Telfer, G. Martin et al., Phthalate and 1112 alkyl phenol concentrations in soil following applications of inorganic fertiliser or 1113 sewage sludge to pasture and potential rates of ingestion by grazing ruminants, J Environ 1114 Monit, vol.4, pp.142-148, 2002.

, Comment citer ce document

C. Viguié, E. Chaillou, V. Gayrard, N. Picard-hagen, and P. A. Fowler, Toward a better understanding of the effects of endocrine disrupting compounds on health: Human-relevant case studies from sheep models, Molecular and Cellular Endocrinology, vol.505, 2020.

M. E. Romano, G. M. Webster, A. M. Vuong, R. Thomas-zoeller, A. Chen et al., , p.1116

A. M. Karagas, M. R. Yolton, K. Lanphear, B. P. Braun, and J. M. , Gestational urinary 1117 bisphenol A and maternal and newborn thyroid hormone concentrations: the HOME 1118 Study, Environ. Res, vol.138, pp.453-460, 2015.

B. B. Roques, M. Z. Lacroix, S. Puel, V. Gayrard, N. Picard-hagen et al., , p.1120

P. G. Viguié and C. , CYP450-Dependent Biotransformation of the Insecticide Fipronil 1121 into Fipronil Sulfone Can Mediate Fipronil-Induced Thyroid Disruption in Rats, 2012.

, Toxicological Sciences, vol.127, pp.29-41

B. B. Roques, J. Leghait, M. Z. Lacroix, F. Lasserre, T. Pineau et al., The 1124 nuclear receptors pregnane X receptor and constitutive androstane receptor contribute 1125 to the impact of fipronil on hepatic gene expression linked to thyroid hormone 1126 metabolism, Biochem. Pharmacol, vol.86, pp.997-1039, 1127.

A. K. Rosenmai, M. Dybdahl, M. Pedersen, A. Van-vugt-lussenburg, B. M. Wedebye et al., , p.1129

C. Taxvig and A. M. Vinggaard, Are Structural Analogues to Bisphenol A Safe 1130 Alternatives?, Toxicological Sciences, vol.139, pp.35-47, 2014.

A. M. Rudolph, Distribution and regulation of blood flow in the fetal and neonatal lamb, 1985.

, Circ. Res, vol.57, pp.811-821

D. W. Rurak, M. R. Wright, and J. E. Axelson, Drug disposition and effects in the fetus, J. Dev. 1134 Physiol, vol.15, pp.33-44, 1991.

L. Savu, R. Vranckx, M. Rouaze-romet, M. Maya, E. A. Nunez et al., A 1136 senescence up-regulated protein: the rat thyroxine-binding globulin (TBG), 1991.

, Biophys. Acta, vol.1097, pp.19-22

B. S. Silva, I. M. Bertasso, C. B. Pietrobon, B. P. Lopes, T. R. Santos et al., , p.1139

S. Claudio-neto, A. C. Manhães, S. S. Cabral, G. E. Kluck, G. C. Atella et al., , p.1140

E. G. Lisboa and P. C. , Effects of maternal bisphenol A on behavior, sex steroid and 1141 thyroid hormones levels in the adult rat offspring, Life Sciences, vol.218, pp.253-264, 1142.

D. G. Skledar, J. Schmidt, A. Fic, I. Klop?i?, J. Trontelj et al., 1144 Influence of metabolism on endocrine activities of bisphenol S, Chemosphere, vol.157, pp.152-1145, 2016.

R. N. Sumner, M. Tomlinson, J. Craigon, G. C. England, and R. G. Lea, Independent and 1147 combined effects of diethylhexyl phthalate and polychlorinated biphenyl 153 on sperm 1148 quality in the human and dog, Sci Rep, vol.9, 2019.

L. Trasande, R. T. Zoeller, U. Hass, A. Kortenkamp, P. Grandjean et al., , p.1151

M. Bellanger, R. Hauser, J. Legler, N. E. Skakkebaek, and J. J. Heindel, Estimating 1152 Burden and Disease Costs of Exposure to Endocrine-Disrupting Chemicals in the 1153 European Union, The Journal of Clinical Endocrinology & Metabolism, vol.100, pp.1245-1255, 1154.

D. K. Tucker, S. Hayes-bouknight, S. S. Brar, G. E. Kissling, and S. E. Fenton, Evaluation of 1156 Prenatal Exposure to Bisphenol Analogues on Development and Long-Term Health of the 1157, 2018.

, Mammary Gland in Female Mice, Environ Health Perspect, vol.126

L. N. Vandenberg, I. Chahoud, J. J. Heindel, V. Padmanabhan, F. J. Paumgartten et al., Urinary, circulating, and tissue biomonitoring studies indicate widespread 1161 exposure to bisphenol A, Cien Saude Colet, vol.17, pp.407-434, 1160.

A. Veiga-lopez, K. Kannan, C. Liao, W. Ye, S. E. Domino et al., Gender-1163 Specific Effects on Gestational Length and Birth Weight by Early Pregnancy BPA 1164 Exposure, The Journal of Clinical Endocrinology & Metabolism, vol.100, pp.1394-1403, 1165.

C. Viguié, S. H. Collet, V. Gayrard, N. Picard-hagen, S. Puel et al., , p.1167

M. Z. , Maternal and fetal exposure to bisphenol a is associated with alterations of 1168 Comment citer ce document, 2013.

C. Viguié, E. Chaillou, V. Gayrard, N. Picard-hagen, and P. A. Fowler, Toward a better understanding of the effects of endocrine disrupting compounds on health: Human-relevant case studies from sheep models, Molecular and Cellular Endocrinology, vol.505, pp.521-1169, 2020.

R. Viñas, R. M. Goldblum, and C. S. Watson, Rapid estrogenic signaling activities of the modified 1171 (chlorinated, sulfonated, and glucuronidated) endocrine disruptor bisphenol A, 2013.

, Endocrine Disruptors 1, e25411

R. Vink, Large animal models of traumatic brain injury, J. Neurosci. Res, vol.96, pp.527-535, 1174.

F. S. Vom-saal, C. A. Vandevoort, J. A. Taylor, W. V. Welshons, P. Toutain et al., , p.1176, 2014.

A. Bisphenol, BPA) pharmacokinetics with daily oral bolus or continuous exposure via 1177 silastic capsules in pregnant rhesus monkeys: Relevance for human exposures

. Toxicol, , vol.45, pp.105-116

N. Walker, P. Filis, U. Soffientini, M. Bellingham, P. J. O'shaughnessy et al., 1180 Placental transporter localization and expression in the Human: the importance of 1181 species, sex, and gestational age differences ?, Biol. Reprod, vol.96, pp.733-742, 1182.

X. Xu, S. Fan, Y. Guo, R. Tan, J. Zhang et al., The effects of perinatal 1184 bisphenol A exposure on thyroid hormone homeostasis and glucose metabolism in the 1185 prefrontal cortex and hippocampus of rats, Brain and Behavior, vol.9, 2019.

J. Yamamoto, M. Minatoya, S. Sasaki, A. Araki, C. Miyashita et al., 1188 Quantifying bisphenol A in maternal and cord whole blood using isotope dilution liquid 1189 chromatography/tandem mass spectrometry and maternal characteristics associated 1190 with bisphenol A, Chemosphere, vol.164, pp.25-31, 2016.

,

X. Ye, L. Wong, J. Kramer, X. Zhou, T. Jia et al., Urinary Concentrations of 1193, 2015.

A. Bisphenol and T. Other, Convenience Samples of U.S. Adults during, vol.49, pp.11834-11839, 1195.

X. Ye, X. Zhou, R. Hennings, J. Kramer, and A. M. Calafat, Potential external contamination 1197 with bisphenol A and other ubiquitous organic environmental chemicals during 1198 biomonitoring analysis: an elusive laboratory challenge, Environ. Health Perspect, vol.121, pp.1199-283, 2013.

Z. Zhang, M. Le-velly, S. M. Rhind, C. E. Kyle, R. L. Hough et al., A study on 1201 temporal trends and estimates of fate of Bisphenol A in agricultural soils after sewage 1202 sludge amendment, Sci. Total Environ. 515, vol.516, pp.1-11, 2015.

,

Z. L. Zhang, C. Leith, S. M. Rhind, C. Kerr, M. Osprey et al., , p.1205

L. Maderova and C. Mckenzie, Long term temporal and spatial changes in the 1206 distribution of polychlorinated biphenyls and polybrominated diphenyl ethers in 1207 Scottish soils, Sci. Total Environ, pp.158-164, 2014.

,

R. T. Zoeller, R. Bansal, and C. Parris, Bisphenol-A, an environmental contaminant that acts as 1210 a thyroid hormone receptor antagonist in vitro, increases serum thyroxine, and alters 1211 RC3/neurogranin expression in the developing rat brain, Endocrinology, vol.146, pp.607-612, 1212.

T. R. Zoeller, Environmental chemicals targeting thyroid, Hormones (Athens), vol.9, pp.28-40, 2010.

T. R. Zoeller, A. L. Dowling, C. T. Herzig, E. A. Iannacone, K. J. Gauger et al., Thyroid 1215 hormone, brain development, and the environment, Environ. Health Perspect, vol.110, pp.355-361, 2002.

, Comment citer ce document

C. Viguié, E. Chaillou, V. Gayrard, N. Picard-hagen, and P. A. Fowler, Toward a better understanding of the effects of endocrine disrupting compounds on health: Human-relevant case studies from sheep models, Molecular and Cellular Endocrinology, vol.505, 2020.