W. M. Johnson and H. Lior, Response of Chinese hamster ovary cells to a cytolethal distending toxin (CDT) of Escherichia coli and possible misinterpretation as heat-labile (LT) enterotoxin, FEMS Microbiol. Lett, vol.43, pp.19-23, 1987.

W. M. Johnson and H. Lior, Production of Shiga toxin and a cytolethal distending toxin (CLDT) by serogroups of Shigella spp, FEMS Microbiol. Lett, vol.48, pp.235-238, 1987.

W. M. Johnson and H. Lior, A new heat-labile cytolethal distending toxin (CLDT) produced by Campylobacter spp, Microb. Pathog, vol.4, pp.115-126, 1988.

W. M. Johnson and H. Lior, A new heat-labile cytolethal distending toxin (CLDT) produced by Escherichia coli isolates from clinical material, Microb. Pathog, vol.4, pp.103-113, 1988.

L. D. Cope, S. Lumbley, J. L. Latimer, J. Klesney-tait, M. K. Stevens et al., A diffusible cytotoxin of Haemophilus ducreyi, Proc. Natl. Acad. Sci, vol.94, pp.4056-4061, 1997.

M. Sugai, T. Kawamoto, H. Komatsuzawa, T. Fujiwara, H. Kurihara et al., The cell cycle-specific growth-inhibitory factor produced by Actinobacillus actinomycetemcomitans is a Cytolethal Distending Toxin, Infect. Immun, vol.66, pp.5008-5019, 1998.

M. P. Mayer, L. C. Bueno, E. J. Hansen, and J. M. Dirienzo, Identification of a Cytolethal Distending Toxin gene locus and features of a virulence-associated region in Actinobacillus actinomycetemcomitans, Infect. Immun, vol.67, pp.1227-1237, 1999.

C. Chien, N. S. Taylor, Z. Ge, D. B. Schauer, B. Young et al., Identification of cdtB homologues and cytolethal distending toxin activity in enterohepatic Helicobacter spp, Bact. Pathog, vol.49, pp.525-534, 2000.

R. N. Jinadasa, S. E. Bloom, R. S. Weiss, and G. E. Duhamel, Cytolethal distending toxin: A conserved bacterial genotoxin that blocks cell cycle progression, leading to apoptosis of a broad range of mammalian cell lineages, Microbiology, vol.157, pp.1851-1875, 2011.

M. D. Scuron, K. Boesze-battaglia, M. Dlaki?, and B. J. Shenker, The Cytolethal Distending Toxin contributes to microbial virulence and disease pathogenesis by acting as a tri-perditious toxin, Front. Cell. Infect. Microbiol, vol.6, p.168, 2016.

D. A. Scott and J. B. Kaper, Cloning and sequencing of the genes encoding Escherichia coli cytolethal distending toxin, Infect. Immun, vol.62, pp.244-251, 1994.

M. Lara-tejero and J. E. Galan, A bacterial toxin that controls cell cycle progression as a deoxyribonuclease I-like protein, vol.290, pp.354-357, 2000.

D. Nesic, Y. Hsu, and C. E. Stebbins, Assembly and function of a bacterial genotoxin, Nature, vol.429, pp.429-433, 2004.

J. Song, X. Gao, and J. E. Galan, Structure and function of the Salmonella Typhi chimaeric A2B5 typhoid toxin, Nature, vol.499, pp.350-354, 2013.

A. Hinenoya, N. Yasuda, N. Mukaizawa, S. Sheikh, Y. Niwa et al., Association of cytolethal distending toxin-II gene-positive Escherichia coli with Escherichia albertii, an emerging enteropathogen, Int. J. Med Microbiol, vol.307, pp.564-571, 2017.

M. Ohguchi, A. Ishisaki, N. Okahashi, M. Koide, T. Koseki et al., Actinobacillus actinomycetemcomitans toxin induces both cell cycle arrest in the G2/M phase and apoptosis, Infect. Immun, vol.66, pp.5980-5987, 1998.

N. P. Liyanage, K. C. Manthey, R. P. Dassanayake, C. A. Kuszynski, G. G. Oakley et al., Helicobacter hepaticus Cytolethal Distending Toxin causes cell death in intestinal epithelial cells via mitochondrial apoptotic pathway, Helicobacter, vol.15, pp.98-107, 2010.

H. Blazkova, K. Krejcikova, P. Moudry, T. Frisan, Z. Hodny et al., Bacterial intoxication evokes cellular senescence with persistent DNA damage and cytokine signalling, J. Cell. Mol. Med, vol.14, pp.357-367, 2010.

S. Y. Peres, O. Marches, F. Daigle, J. Nougayrede, F. Herault et al., A new cytolethal distending toxin (CDT) from Escherichia coli producing CNF2 blocks HeLa cell division in G2/M phase, Mol. Microbiol, vol.24, pp.1095-1107, 1997.

C. Comayras, C. Tasca, E. Oswald, and J. D. Rycke, Escherichia coli Cytolethal Distending Toxin blocks the HeLa cell cycle at the G2/M transition by preventing cdc2 protein kinase dephosphorylation and activation, Infect. Immun, vol.65, pp.508-5095, 1997.

X. Cortes-bratti, C. Karlsson, T. Lagergård, M. Thelestam, and T. Frisan, The Haemophilus ducreyi Cytolethal Distending Toxin induces cell cycle arrest and apoptosis via the DNA damage checkpoint pathways, J. Biol. Chem, vol.276, pp.5296-5302, 2001.

G. N. Belibasakis, A. Mattsson, Y. Wang, C. Chen, and A. Johansson, Cell cycle arrest of human gingival fibroblasts and periodontal ligament cells by Actinobacillus actinomycetemcomitans: Involvement of the cytolethal distending toxin, Apmis, vol.112, pp.674-685, 2004.

L. Li, A. Sharipo, E. Chaves-olarte, M. G. Masucci, V. Levitsky et al., The Haemophilus ducreyi cytolethal distending toxin activates sensors of DNA damage and repair complexes in proliferating and non-proliferating cells, Cell. Microbiol, vol.4, pp.87-99, 2002.

T. Frisan, X. Cortes-bratti, E. Chaves-olarte, B. Stenerlow, and M. Thelestam, The Haemophilus ducreyi cytolethal distending toxin induces DNA double-strand breaks and promotes ATM-dependent activation of RhoA, Cell. Microbiol, vol.5, pp.695-707, 2003.

Y. Fedor, J. Vignard, M. Nicolau-travers, E. Boutet-robinet, C. Watrin et al., From single-strand breaks to double-strand breaks during S-phase: A new mode of action of the Escherichia coli Cytolethal Distending Toxin: A new mode of action for CDT, Cell. Microbiol, vol.15, pp.1-15, 2013.

J. Fahrer, J. Huelsenbeck, H. Jaurich, B. Dörsam, T. Frisan et al., Cytolethal distending toxin (CDT) is a radiomimetic agent and induces persistent levels of DNA double-strand breaks in human fibroblasts, DNA Repair, vol.18, pp.31-43, 2014.

E. Bezine, Y. Malaisé, A. Loeuillet, M. Chevalier, E. Boutet-robinet et al., Cell resistance to the Cytolethal Distending Toxin involves an association of DNA repair mechanisms, Sci. Rep, vol.6, pp.1-15, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01602345

B. J. Shenker, K. Boesze-battaglia, M. D. Scuron, L. P. Walker, A. Zekavat et al., The toxicity of the Aggregatibacter actinomycetemcomitans cytolethal distending toxin correlates with its phosphatidylinositol-3,4,5-triphosphate phosphatase activity: Cdt toxicity is dependent on PIP3 phosphatase activity, Cell. Microbiol, vol.18, pp.223-243, 2015.

E. Bezine, J. Vignard, and G. Mirey, The Cytolethal Distending Toxin effects on mammalian cells: A DNA damage perspective, vol.3, pp.592-615, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01192559

J. Okuda, M. Fukumoto, Y. Takeda, and M. Nishibuchi, Examination of diarrheagenicity of Cytolethal Distending Toxin: Suckling mouse response to the products of the cdtABC genes of Shigella dysenteriae, Infect. Immun, vol.65, pp.428-433, 1997.

J. G. Fox, A. B. Rogers, M. T. Whary, Z. Ge, N. S. Taylor et al., Gastroenteritis in NF-B-deficient mice is produced with Wild-Type Camplyobacter jejuni but not with C. jejuni lacking Cytolethal Distending Toxin despite persistent colonization with both strains, Infect. Immun, vol.72, pp.1116-1125, 2004.

D. Jain, K. N. Prasad, S. Sinha, and N. Husain, Differences in virulence attributes between cytolethal distending toxin positive and negative Campylobacter jejuni strains, J. Med Microbiol, vol.57, pp.267-272, 2008.

Z. Ge, Y. Feng, M. T. Whary, P. R. Nambiar, S. Xu et al., Cytolethal Distending Toxin is essential for Helicobacter hepaticus colonization in outbred Swiss Webster mice, Infect. Immun, vol.73, pp.3559-3567, 2005.

J. S. Pratt, K. L. Sachen, H. D. Wood, K. A. Eaton, and V. B. Young, Modulation of host immune responses by the Cytolethal Distending Toxin of Helicobacter hepaticus, Infect. Immun, vol.74, pp.4496-4504, 2006.

T. E. Hickey, A. L. Mcveigh, D. A. Scott, R. E. Michielutti, A. Bixby et al., Campylobacter jejuni Cytolethal Distending Toxin mediates release of Interleukin-8 from intestinal epithelial cells, Infect. Immun, vol.68, pp.6535-6541, 2000.

C. Péré-védrenne, B. Cardinaud, C. Varon, I. Mocan, A. Buissonnière et al., The Cytolethal Distending Toxin subunit CdtB of Helicobacter Induces a Th17-related and antimicrobial signature in intestinal and hepatic cells in vitro, J. Infect. Dis, vol.213, 1979.

V. Gelfanova, E. J. Hansen, and S. M. Spinola, Cytolethal Distending Toxin of Haemophilus ducreyi induces apoptotic death of Jurkat T cells, Infect. Immun, vol.67, pp.6394-6402, 1999.

B. J. Shenker, T. Mckay, S. Datar, M. Miller, R. Chowhan et al., Actinobacillus actinomycetemcomitans immunosuppressive protein is a member of the family of Cytolethal Distending Toxins capable of causing a G2 arrest in human T cells, J. Immunol, vol.162, pp.4773-4780, 1999.

L. A. Svensson, A. Tarkowski, M. Thelestam, and T. Lagergård, The impact of Haemophilus ducreyi Cytolethal Distending Toxin on cells involved in immune response, Microb. Pathog, vol.30, pp.157-166, 2001.

S. D. Rabin, J. G. Flitton, and D. R. Demuth, Aggregatibacter actinomycetemcomitans Cytolethal Distending Toxin induces apoptosis in non-proliferating macrophages by a phosphatase-independent mechanism, Infect. Immun, vol.77, pp.3161-3169, 2009.

E. S. Ando-suguimoto, M. P. Silva, D. Kawamoto, C. Chen, J. M. Dirienzo et al., The Cytolethal Distending Toxin of Aggregatibacter actinomycetemcomitans inhibits macrophage phagocytosis and subverts cytokine production, Cytokine, vol.66, pp.46-53, 2014.

B. J. Shenker, L. P. Walker, A. Zekavat, M. Dlaki?, and K. Boesze-battaglia, Blockade of the PI-3K signalling pathway by the Aggregatibacter actinomycetemcomitans Cytolethal Distending Toxin induces macrophages to synthesize and secrete pro-inflammatory cytokines: Cdt induces macrophage synthesis of cytokines, Cell Microbiol, vol.16, pp.1391-1404, 2014.

K. Williams, K. Gokulan, D. Shelman, T. Akiyama, A. Khan et al., Cytotoxic mechanism of Cytolethal Distending Toxin in nontyphoidal Salmonella serovar (Salmonella Javiana) during macrophage infection, DNA Cell Biol, vol.34, pp.113-124, 2015.

M. Damek-poprawa, M. Haris, A. Volgina, J. Korostoff, and J. M. Dirienzo, Cytolethal Distending Toxin damages the oral epithelium of gingival explants, J. Dent. Res, vol.90, pp.874-879, 2011.

M. Damek-poprawa, J. Korostoff, R. Gill, and J. M. Dirienzo, Cell junction remodeling in gingival tissue exposed to a microbial toxin, J. Dent. Res, vol.92, pp.518-523, 2013.

E. Buc, D. Dubois, P. Sauvanet, J. Raisch, J. Delmas et al., High prevalence of mucosa-associated E. coli producing cyclomodulin and genotoxin in colon cancer, PLoS ONE, vol.8, 2013.

Z. Ge, A. B. Rogers, Y. Feng, A. Lee, S. Xu et al., Bacterial cytolethal distending toxin promotes the development of dysplasia in a model of microbially induced hepatocarcinogenesis, Cell. Microbiol, vol.9, pp.2070-2080, 2007.

Z. Ge, Y. Feng, L. Ge, N. Parry, S. Muthupalani et al., Helicobacter hepaticus cytolethal distending toxin promotes intestinal carcinogenesis in 129 ag2 -deficient mice, Cell. Microbiol, vol.19, pp.1-11, 2017.

Z. He, R. Z. Gharaibeh, R. C. Newsome, J. L. Pope, M. W. Dougherty et al., Campylobacter jejuni promotes colorectal tumorigenesis through the action of cytolethal distending toxin, Gut, vol.68, pp.289-300, 2019.

R. Guidi, L. Guerra, L. Levi, B. Stenerlöw, J. G. Fox et al., Chronic exposure to the Cytolethal Distending Toxins of Gram-negative bacteria promotes genomic instability and altered DNA damage response: Bacterial toxin and genomic instability, Cell. Microbiol, vol.15, pp.98-113, 2013.

V. Graillot, I. Dormoy, J. Dupuy, J. W. Shay, L. Huc et al., Genotoxicity of Cytolethal Distending Toxin (CDT) on isogenic human colorectal cell lines: Potential promoting effects for colorectal carcinogenesis, Front. Cell. Infect. Microbiol, vol.6, pp.1-13, 2016.

C. L. Pickett, D. L. Cottle, E. C. Pesci, and G. Bikah, Cloning, sequencing, and expression of the Escherichia coli Cytolethal Distending Toxin genes, Infect. Immun, vol.62, pp.1046-1051, 1994.

Y. Ueno, M. Ohara, T. Kawamoto, T. Fujiwara, H. Komatsuzawa et al., Biogenesis of the Actinobacillus actinomycetemcomitans Cytolethal Distending Toxin holotoxin, Infect. Immun, vol.74, pp.3480-3487, 2006.

V. Zijnge, T. Kieselbach, and J. Oscarsson, Proteomics of protein secretion by Aggregatibacter actinomycetemcomitans, PLoS ONE, vol.7, 2012.

B. Lindmark, P. Rompikuntal, K. Vaitkevicius, T. Song, Y. Mizunoe et al., Outer membrane vesicle-mediated release of cytolethal distending toxin (CDT) from Campylobacter jejuni, BMC Microbiol, vol.9, pp.220-230, 2009.

S. Spanò, J. E. Ugalde, and J. E. Galan, Delivery of a Salmonella Typhi exotoxin from a host intracellular compartment, Cell Host Microbe, vol.3, pp.30-38, 2008.

E. Haghjoo and J. E. Galan, Salmonella Typhi encodes a functional cytolethal distending toxin that is delivered into host cells by a bacterial-internalization pathway, Proc. Natl. Acad. Sci, vol.101, pp.4614-4619, 2004.

R. B. Lee, D. C. Hassane, D. L. Cottle, and C. L. Pickett, Interactions of Campylobacter jejuni Cytolethal Distending Toxin subunits CdtA and CdtC with HeLa cells, Infect. Immun, vol.71, pp.4883-4890, 2003.

L. A. Mcsweeney and L. A. Dreyfus, Carbohydrate-binding specificity of the Escherichia coli Cytolethal Distending Toxin CdtA-II and CdtC-II subunits, Infect. Immun, vol.73, pp.2051-2060, 2005.

A. Eshraghi, F. J. Maldonado-arocho, A. Gargi, M. M. Cardwell, M. G. Prouty et al., Cytolethal Distending Toxin family members are differentially affected by alterations in host glycans and membrane cholesterol, J. Biol. Chem, vol.285, pp.18199-18207, 2010.

J. E. Carette, C. P. Guimaraes, I. Wuethrich, V. A. Blomen, M. Varadarajan et al., Global gene disruption in human cells to assign genes to phenotypes by deep sequencing, Nat. Biotechnol, vol.29, pp.542-546, 2011.

K. Boesze-battaglia, L. P. Walker, A. Zekavat, M. Dlaki?, M. D. Scuron et al., The Aggregatibacter actinomycetemcomitans Cytolethal Distending Toxin active subunit CdtB contains a cholesterol recognition sequence required for toxin binding and subunit internalization, Infect. Immun, vol.83, pp.4042-4055, 2015.

S. Akifusa, W. Heywood, S. P. Nair, G. Stenbeck, and B. Henderson, Mechanism of internalization of the Cytolethal Distending Toxin of Actinobacillus actinomycetemcomitans, Microbiology, vol.151, pp.1395-1402, 2005.

M. Damek-poprawa, J. Y. Jang, A. Volgina, J. Korostoff, and J. M. Dirienzo, Localization of Aggregatibacter actinomycetemcomitans Cytolethal Distending Toxin subunits during intoxication of live cells, Infect. Immun, vol.80, pp.2761-2770, 2012.

X. Cortes-bratti, E. Chaves-olarte, T. Lagergard, and M. Thelestam, Cellular internalization of Cytolethal Distending Toxin from Haemophilus ducreyi, Infect. Immun, vol.68, pp.6903-6911, 2000.

S. D. Dixon, M. M. Huynh, B. Tamilselvam, L. M. Spiegelman, S. B. Son et al., Distinct roles for CdtA and CdtC during intoxication by Cytolethal Distending Toxins, PLoS ONE, vol.10, 2015.

S. Nishikubo, M. Ohara, Y. Ueno, M. Ikura, H. Kurihara et al., An N-terminal segment of the active component of the bacterial genotoxin Cytolethal Distending Toxin B (CDTB) directs CDTB into the nucleus, J. Biol. Chem, vol.278, pp.50671-50681, 2003.

L. A. Mcsweeney and L. A. Dreyfus, Nuclear localization of the Escherichia coli Cytolethal Distending Toxin CdtB subunit, Cell. Microbiol, vol.6, pp.447-458, 2004.

L. Guerra, K. Teter, B. N. Lilley, B. Stenerlöw, R. K. Holmes et al., Cellular internalization of cytolethal distending toxin: A new end to a known pathway: Internalization of bacterial toxin, Cell. Microbiol, vol.7, pp.921-934, 2005.

A. Gargi, B. Tamilselvam, B. Powers, M. G. Prouty, T. Lincecum et al., Cellular interactions of the Cytolethal Distending Toxins from Escherichia coli and Haemophilus ducreyi, J. Biol. Chem, vol.288, pp.7492-7505, 2013.

T. Frisan, Bacterial genotoxins: The long journey to the nucleus of mammalian cells, Biochim. Biophys. Acta (BBA)-Biomembr, vol.1858, pp.567-575, 2016.

X. Hu, D. Nesic, and C. E. Stebbins, Comparative structure-function analysis of Cytolethal Distending Toxins, Proteins, vol.62, pp.421-434, 2005.

C. A. Elwell and L. A. Dreyfus, DNase I homologous residues in CdtB are critical for Cytolethal Distending Toxin-mediated cell cycle arrest, Mol. Microbiol, vol.37, pp.952-963, 2000.

C. Q. Pan, J. S. Uumer, A. Herzka, and R. A. Lazarus, Mutational analysis of human DNase I at the DNA binding interface: Implications for DNA recognition, catalysis, and metal ion dependence, Protein Sci, vol.7, pp.628-636, 1998.

M. Dlakic, Functionally unrelated signalling proteins contain a fold similar to Mg 2+ -dependent endonucleases, Trends Biochem. Sci, vol.25, pp.272-273, 2000.

P. Avenaud, M. Castroviejo, S. Claret, J. Rosenbaum, F. Mégraud et al., Expression and activity of the Cytolethal Distending Toxin of Helicobacter hepaticus, Biochem. Biophys. Res. Commun, vol.318, pp.739-745, 2004.

B. J. Shenker, M. Dlakic, L. P. Walker, D. Besack, E. Jaffe et al., A novel mode of action for a microbial-derived immunotoxin: The Cytolethal Distending Toxin subunit B exhibits phosphatidylinositol 3,4,5-triphosphate phosphatase activity, J. Immunol, vol.178, pp.5099-5108, 2007.

J. S. Hontz, M. T. Villar-lecumberri, B. M. Potter, M. D. Yoder, L. A. Dreyfus et al., Differences in crystal and solution structures of the Cytolethal Distending Toxin B subunit, J. Biol. Chem, vol.281, pp.25365-25372, 2006.

X. Hu and C. E. Stebbins, Dynamics and assembly of the Cytolethal Distending Toxin, Proteins, vol.65, pp.843-855, 2006.

T. Yamada, J. Komoto, K. Saiki, K. Konishi, and F. Takusagawa, Variation of loop sequence alters stability of Cytolethal Distending Toxin (CDT): Crystal structure of CDT from Actinobacillus actinomycetemcomitans, Protein Sci, vol.15, pp.362-372, 2006.

J. S. Hontz, M. T. Villar-lecumberri, L. A. Dreyfus, and M. D. Yoder, Crystallization of Escherichia coli CdtB, the biologically active subunit of cytolethal distending toxin, Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun, vol.62, pp.192-195, 2006.

V. W. Campbell and D. A. Jackson, The effect of divalent cations on the mode of action of DNase I. The initial reaction products produced from covalently closed circular DNA, J. Biol. Chem, vol.255, pp.3726-3735, 1980.

C. Q. Pan and R. A. Lazarus, Engineering hyperactive variants of human Deoxyribonuclease I by altering its functional mechanism, Biochemistry, vol.36, pp.6624-6632, 1997.

C. Elwell, K. Chao, K. Patel, and L. Dreyfus, Escherichia coli CdtB mediates Cytolethal Distending Toxin cell cycle arrest, Infect. Immun, vol.69, pp.3418-3422, 2001.

R. P. Dassanayake, M. A. Griep, and G. E. Duhamel, The Cytolethal Distending Toxin B sub-unit of Helicobacter hepaticus is a Ca 2+ -and Mg 2+ -dependent neutral nuclease, FEMS Microbiol. Lett, pp.219-225, 2005.

J. M. Dirienzo, L. Cao, A. Volgina, G. Bandelac, and J. Korostoff, Functional and structural characterization of chimeras of a bacterial genotoxin and human type I DNAse, FEMS Microbiol. Lett, vol.291, pp.222-231, 2009.

S. Nishikubo, M. Ohara, M. Ikura, K. Katayanagi, T. Fujiwara et al., Single nucleotide polymorphism in the Cytolethal Distending Toxin B gene confers heterogeneity in the cytotoxicity of Actinobacillus actinomycetemcomitans, Infect. Immun, vol.74, pp.7014-7020, 2006.

D. Obradovi?, R. Ga?per?i?, S. Caserman, A. Leonardi, M. Jamnik et al., A Cytolethal Distending Toxin variant from Aggregatibacter actinomycetemcomitans with an aberrant CdtB that lacks the conserved catalytic Histidine 160, PLoS ONE, vol.11, p.159231, 2016.

B. J. Pons, E. Bezine, M. Hanique, V. Guillet, L. Mourey et al., Cell transfection of purified Cytolethal Distending Toxin B subunits allows comparing their nuclease activity while plasmid degradation assay does not, PLoS ONE, vol.14, 2019.
URL : https://hal.archives-ouvertes.fr/hal-02346660

F. Taieb, J. Nougayrède, C. Watrin, A. Samba-louaka, and E. Oswald, Escherichia coli cyclomodulin Cif induces G2 arrest of the host cell cycle without activation of the DNA-damage checkpoint-signalling pathway, Cell. Microbiol, vol.8, pp.1910-1921, 2006.

K. Backers, D. Blero, N. Paternotte, J. Zhang, and C. Erneux, The termination of PI3K signalling by SHIP1 and SHIP2 inositol 5-phosphatases, Adv. Enzym. Regul, vol.43, pp.15-28, 2003.

O. Matangkasombut, R. Wattanawaraporn, K. Tsuruda, M. Ohara, M. Sugai et al., Cytolethal Distending Toxin from Aggregatibacter actinomycetemcomitans induces DNA damage, S/G2 cell cycle arrest, and caspase-independent death in a Saccharomyces cerevisiae model, Infect. Immun, vol.78, pp.783-792, 2010.

Z. Ge, Y. Feng, A. Sheh, S. Muthupalani, G. Gong et al., Mutagenicity of Helicobacter hepaticus infection in the lower bowel mucosa of 129/SvEv Rag2 -/-Il10 -/-gpt delta mice is influenced by sex, Int. J. Cancer, vol.145, pp.1042-1054, 2019.

G. Li, H. Niu, Y. Zhang, Y. Li, F. Xie et al., Haemophilus parasuis Cytolethal Distending Toxin induces cell cycle arrest and p53-dependent apoptosis, PLoS ONE, vol.12, p.177199, 2017.

D. C. Hassane, R. B. Lee, M. D. Mendenhall, and C. L. Pickett, Cytolethal Distending Toxin demonstrates genotoxic activity in a yeast model, Infect. Immun, vol.69, pp.5752-5759, 2001.

D. C. Hassane, R. B. Lee, and C. L. Pickett, Campylobacter jejuni Cytolethal Distending Toxin promotes DNA repair responses in normal human cells, Infect. Immun, vol.71, pp.541-545, 2003.

M. Ohara, T. Hayashi, Y. Kusunoki, K. Nakachi, T. Fujiwara et al., Cytolethal Distending Toxin induces caspase-dependent and -independent cell death in MOLT-4 Cells, Infect. Immun, vol.76, pp.4783-4791, 2008.

M. Ohara, M. Miyauchi, K. Tsuruda, T. Takata, and M. Sugai, Topical application of Aggregatibacter actinomycetemcomitans Cytolethal Distending Toxin induces cell cycle arrest in the rat gingival epithelium in vivo: CDT induces cell cycle arrest in rat gingival epithelium, J. Periodontal Res, vol.46, pp.389-395, 2011.

C. Péré-védrenne, M. Prochazkova-carlotti, B. Rousseau, W. He, L. Chambonnier et al., The Cytolethal Distending Toxin subunit CdtB of Helicobacter hepaticus promotes senescence and endoreplication in xenograft mouse models of hepatic and intestinal cell lines, Front. Cell. Infect. Microbiol, vol.7, pp.1-14, 2017.

N. Seiwert, C. Neitzel, S. Stroh, T. Frisan, M. Audebert et al., AKT2 suppresses pro-survival autophagy triggered by DNA double-strand breaks in colorectal cancer cells, Cell Death Dis, vol.8, pp.1-14, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01604854

T. Frisan, N. Nagy, D. Chioureas, M. Terol, F. Grasso et al., A bacterial genotoxin causes virus reactivation and genomic instability in Epstein-Barr virus infected epithelial cells pointing to a role of co-infection in viral oncogenesis: Bacterial co-infection in EBV oncogenesis, Int. J. Cancer, vol.144, pp.98-109, 2018.

H. Chen, L. Li, X. Chen, M. Yang, Y. Ye et al., The mechanism of Jurkat cells apoptosis induced by Aggregatibacter actinomycetemcomitans cytolethal distending toxin, Apoptosis, vol.22, pp.841-851, 2017.

H. Turkez, M. E. Arslan, and O. Ozdemir, Genotoxicity testing: Progress and prospects for the next decade, Expert Opin. Drug Metab. Toxicol, vol.13, pp.1089-1098, 2017.