Sex determination in mythology and history, Arq. Bras. Endocrinol. Metabol, vol.49, pp.7-13, 2005. ,
Genetics of Sexual Development: An Evolutionary Playground for Fish, Genetics, vol.196, pp.579-591, 2014. ,
Fish sex: why so diverse?, Curr. Opin. Neurobiol, vol.19, pp.648-653, 2009. ,
From the Origin of Sex-Determining Factors to the Evolution of Sex-Determining Systems, Q. Rev. Biol, vol.86, pp.163-180, 2011. ,
A W-linked DM-domain gene, DM-W, participates in primary ovary development in Xenopus laevis, Proc. Natl. Acad. Sci. USA 105, pp.2469-2474, 2008. ,
A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif, Nature, vol.346, pp.240-244, 1990. ,
Male development of chromosomally female mice transgenic for Sry, Nature, vol.351, pp.117-121, 1991. ,
The avian Z-linked gene DMRT1 is required for male sex determination in the chicken, Nature, vol.461, pp.267-271, 2009. ,
DMY is a Y-specific DM-domain gene required for male development in the medaka fish, Nature, vol.417, 2002. ,
Tracing the Emergence of a Novel Sex-Determining Gene in Medaka, Oryzias luzonensis, Genetics, vol.191, pp.163-170, 2012. ,
A Y-linked anti-Mu?llerian hormone duplication takes over a critical role in sex determination, Proc. Natl. Acad. Sci. USA, vol.109, pp.2955-2959, 2012. ,
A Trans-Species Missense SNP in Amhr2 Is Associated with Sex Determination in the Tiger Pufferfish, Takifugu rubripes (Fugu), vol.8, p.1002798, 2012. ,
An Immune-Related Gene Evolved into the Master Sex-Determining Gene in Rainbow Trout, Oncorhynchus mykiss, Curr. Biol, vol.22, pp.1423-1428, 2012. ,
URL : https://hal.archives-ouvertes.fr/hal-01000319
Co-option of Sox3 as the male-determining factor on the Y chromosome in the fish Oryzias dancena, Nat. Commun, vol.5, p.4157, 2014. ,
Whole-genome sequence of a flatfish provides insights into ZW sex chromosome evolution and adaptation to a benthic lifestyle, Nat Genet, vol.46, pp.253-260, 2014. ,
Characterization of gonadal transcriptomes from Nile tilapia (Oreochromis niloticus) reveals differentially expressed genes, PLoS One, vol.8, p.63604, 2013. ,
, SCIenTIfIC RePoRTS |, vol.8, p.3564, 2018.
Expression Profiling of Wnt Signaling Genes during Gonadal Differentiation and Gametogenesis in Rainbow Trout, Sex. Dev, vol.5, pp.318-329, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-01205051
Sexual dimorphic expression of DMRT1 and Sox9a during gonadal differentiation and hormone-induced sex reversal in the teleost fish Nile tilapia (Oreochromis niloticus), Dev. Dyn, vol.237, pp.297-306, 2008. ,
Male-specific DNA markers from African catfish (Clarias gariepinus), Genetica, vol.110, pp.267-276, 2000. ,
Isolation and Physical Mapping of Sex-Linked AFLP Markers in Nile Tilapia (Oreochromis niloticus L.), Mar. Biotechnol, vol.6, pp.435-445, 2004. ,
An AFLP-based approach for the identification of sex-linked markers in rainbow trout (Oncorhynchus mykiss), Aquaculture, vol.247, pp.35-43, 2005. ,
Identification of the Major Sex-Determining Region of Turbot (Scophthalmus maximus), Genetics, vol.183, pp.1443-1452, 2009. ,
Construction of Two BAC Libraries from Half-Smooth Tongue Sole Cynoglossus semilaevis and Identification of Clones Containing Candidate Sex-DeterminationGenes, Mar. Biotechnol, vol.12, pp.558-568, 2010. ,
Assignment of Chinook Salmon (Oncorhynchus tshawytscha) Linkage Groups to Specific Chromosomes Reveals a Karyotype with Multiple Rearrangements of the Chromosome Arms of Rainbow Trout (Oncorhynchus mykiss), G3 Genes|Genomes|Genetics, vol.3, pp.2289-2295, 2013. ,
Characterization of sex chromosomes in rainbow trout and coho salmon using fluorescence in situ hybridization (FISH), Genetica, vol.111, pp.125-131, 2001. ,
Identification and Characterization of Sex-Associated Loci in Sockeye Salmon Using Genotyping-by-Sequencing and Comparison with a Sex-Determining Assay Based on the sdY Gene, J. Hered, vol.107, pp.559-566, 2016. ,
Turnover of Sex Chromosomes in the Stickleback Fishes (Gasterosteidae), PLoS Genet, vol.5, p.1000391, 2009. ,
Independent fusions and recent origins of sex chromosomes in the evolution and diversification of glass knife fishes (Eigenmannia), Heredity (Edinb), vol.106, pp.391-400, 2011. ,
A new SNP-based vision of the genetics of sex determination in European sea bass (Dicentrarchus labrax), Genet. Sel. Evol, vol.47, p.68, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-01341305
Reproduction and broodstock management, Sparidae: Biology and Aquaculture of Gilthead Sea Bream and Other Species, pp.95-131, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-01205011
Alternative reproductive styles in seabreams (Pisces: Sparidae), Environ. Biol. Fishes, vol.28, pp.113-124, 1990. ,
The switch of secondary sex determination in protandrous black porgy, Acanthopagrus schlegeli, Fish Physiol. Biochem, vol.39, pp.33-38, 2013. ,
Differential Dmrt1 transcripts in gonads of the protandrous black porgy, Acanthopagrus schlegeli, Cytogenet. Genome Res, vol.101, pp.309-313, 2003. ,
Quantitative trait loci for body growth and sex determination in the hermaphrodite teleost fish Sparus aurata L, Anim Genet, vol.43, pp.753-759, 2012. ,
The sex-specific transcriptome of the hermaphrodite sparid sharpsnout seabream (Diplodus puntazzo), BMC Genomics, vol.15, p.655, 2014. ,
Phylogenetic Perspectives on the Evolution of Functional Hermaphroditism in Teleost Fishes, Integr. Comp. Biol, 2013. ,
Small-scale transcriptomics reveals differences among gonadal stages in Asian seabass (Lates calcarifer), Reprod. Biol. Endocrinol, vol.12, pp.1-14, 2014. ,
Large-scale transcriptome sequencing reveals novel expression patterns for key sex-related genes in a sex-changing fish, Biol. Sex Differ, vol.6, p.26, 2015. ,
, Sex Change in Clownfish: Molecular Insights from Transcriptome Analysis. Sci. Rep, vol.6, p.35461, 2016.
Current status of Sparidae aquaculture, Sparidae: Biology and Aquaculture of Gilthead Sea Bream and Other Species, pp.1-50 ,
, Fishes of the North-eastern Atlantic and the Mediterranean, vol.2, 1986.
Plasticity of gonadal development and protandry in fishes, J. Exp. Zool, vol.261, pp.194-203, 1992. ,
Sex change and sexual selection. Science (80-), vol.190, p.633, 1975. ,
A chromosome study of eight Mediterranean species of Sparidae (pisces, perciformes), Genetica, vol.54, pp.155-159, 1980. ,
Exploring a Nonmodel Teleost Genome Through RAD Sequencing-Linkage Mapping in Common Pandora, Pagellus erythrinus and Comparative Genomic Analysis, G3 Genes|Genomes|Genetics, vol.6, pp.509-519, 2016. ,
Evolutionary Perspectives on Hermaphroditism in Fishes, Sex. Dev, vol.3, pp.152-163, 2009. ,
Neuroendocrinology of sexual plasticity in teleost fishes, Front. Neuroendocrinol, vol.31, pp.203-216, 2010. ,
Neuroendocrine regulation in sex-changing fishes, Hormones and Reproduction of Vertebrates: Fishes, vol.1, pp.149-168, 2011. ,
RNA-Seq: a revolutionary tool for transcriptomics, Nat Rev Genet, vol.10, 2009. ,
The control of sexual differentiation of the reproductive system and brain, Reproduction, vol.133, pp.331-359, 2007. ,
Fast gapped-read alignment with Bowtie 2, Nat Methods, vol.9, 2012. ,
UniProt: a hub for protein information, Nucleic Acids Res, vol.43, pp.204-212, 2015. ,
InterProScan: protein domains identifier, Nucleic Acids Res, vol.33, pp.116-120, 2005. ,
Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research, Bioinformatics, vol.21, pp.3674-3676, 2005. ,
WEGO: a web tool for plotting GO annotations, Nucleic Acids Res, vol.34, pp.293-297, 2006. ,
Sex-Biased Gene Expression, Annu. Rev. Genet, 2015. ,
Comparative Transcriptomics in East African Cichlids Reveals Sex-and Species-Specific Expression and New Candidates for Sex Differentiation in Fishes, Genome Biol Evol, vol.6, pp.2567-2585, 2014. ,
Sex differences and similarities in the neuroendocrine regulation of social behavior in an African cichlid fish, Horm. Behav, vol.64, pp.468-476, 2013. ,
Genomic organization of ZP domain containing egg envelope genes in medaka (Oryzias latipes), Gene, vol.305, pp.35-45, 2003. ,
Molecular Characterization and Expression Pattern of Zona Pellucida Proteins in Gilthead Seabream (Sparus aurata)1, Biol. Reprod, vol.75, pp.717-725, 2006. ,
, SCIenTIfIC RePoRTS |, vol.8, p.3564, 2018.
Cloning of rainbow trout egg envelope proteins: members of a unique group of structural proteins, Biol. Reprod, vol.64, pp.805-811, 2001. ,
Neurobeachin regulates neurotransmitter receptor trafficking to synapses, J. Cell Biol, vol.200, p.61, 2013. ,
Signaling Pathways Involved in Mammalian Sex Determination and Gonad Development, Sex. Dev, vol.9, pp.297-315, 2015. ,
Rapid activation of phosphorylated MAPK after sexual stimulation in male mice, Neuroreport, vol.22, pp.294-298, 2011. ,
Evolutionary conservation of the egr-1 immediate-early gene response in a teleost, J. Comp. Neurol, vol.481, pp.220-232, 2005. ,
Female genomic response to mate information, Proc. Natl. Acad. Sci. USA, vol.107, pp.21176-21180, 2010. ,
Aromatase, brain sexualization and plasticity: the fish paradigm, Eur. J. Neurosci, vol.32, pp.2105-2115, 2010. ,
URL : https://hal.archives-ouvertes.fr/hal-00586266
The unique genomic properties of sex-biased genes: Insights from avian microarray data, BMC Genomics, vol.9, p.148, 2008. ,
The testis and ovary transcriptomes of the rock bream (Oplegnathus fasciatus): A bony fish with a unique neo Y chromosome, Genomics Data, vol.7, pp.210-213, 2016. ,
Non-canonical expression patterns and evolutionary rates of sex-biased genes in a seasonal fish, Mol. Reprod. Dev, 2016. ,
Male sex drive and the masculinization of the genome, BioEssays, vol.27, pp.518-525, 2005. ,
Governing Sex Determination in Fish: Regulatory Putsches and Ephemeral Dictators, Sex. Dev, vol.1, pp.85-99, 2007. ,
The remarkable reproductive diversity of teleost fishes, Fish Fish, vol.17, pp.1208-1215, 2016. ,
Divergent Expression Regulation of Gonad Development Genes in Medaka Shows Incomplete Conservation of the Downstream Regulatory Network of Vertebrate Sex Determination, Mol. Biol. Evol, vol.30, pp.2328-2346, 2013. ,
URL : https://hal.archives-ouvertes.fr/hal-01205076
Expression and Sequence Evolution of Aromatase cyp19a1 and Other Sexual Development Genes in East African Cichlid Fishes, Mol. Biol. Evol, vol.30, pp.2268-2285, 2013. ,
Structure and function of the zona pellucida: Identification and characterization of the proteins of the mouse oocyte's zona pellucida, Dev. Biol, vol.76, pp.185-202, 1980. ,
In vitro biosynthesis of three sulfated glycoproteins of murine zonae pellucidae by oocytes grown in follicle culture, J. Biol. Chem, vol.258, pp.5858-5863, 1983. ,
FIGalpha, a germ cell specific transcription factor involved in the coordinate expression of the zona pellucida genes, Development, vol.124, p.4939, 1997. ,
Testicular dmrt1 Is Involved in the Sexual Fate of the Ovotestis in the Protandrous Black Porgy, Biol. Reprod, vol.86, p.41, 2012. ,
Molecular Cloning and Expression Profile of Sex-SpecificGenes, Figla and Dmrt1, in the Protogynous Hermaphroditic Fish, Halichoeres Poecilopterus. Zoolog. Sci, vol.29, pp.690-710, 2012. ,
At the Crossroads of Female Sex Determination and Ovarian Function, Forkhead Transcription Factors: Vital Elements in Biology and Medicine, pp.207-226, 2010. ,
URL : https://hal.archives-ouvertes.fr/hal-00512786
Gonadal sex differentiation and expression of Sox9a2, Dmrt1 and Foxl2 in Oryzias luzonensis, genesis, vol.47, pp.289-299, 2009. ,
Molecular cloning and gene expression of Foxl2 in the Nile tilapia, Oreochromis niloticus, Biochem. Biophys. Res. Commun, vol.320, pp.83-89, 2004. ,
Molecular cloning and analysis of gonadal expression of Foxl2 in the medaka, Oryzias latipes. Biochem. Biophys. Res. Commun, vol.344, pp.353-361, 2006. ,
Molecular cloning of doublesex and mab-3-related transcription factor 1, forkhead transcription factor gene 2 and two types of cytochrome P450 aromatase in Southern catfish and their possible roles in sex differentiation, J. Endocrinol, vol.194, pp.223-241, 2007. ,
Ovarian aromatase and estrogens: A pivotal role for gonadal sex differentiation and sex change in fish, Gen. Comp. Endocrinol, vol.165, pp.352-366, 2010. ,
URL : https://hal.archives-ouvertes.fr/hal-01205022
Suppression of P450 aromatase gene expression in sex-reversed males produced by rearing genetically female larvae at a high water temperature during a period of sex differentiation in the Japanese flounder (Paralichthys olivaceus), J. Mol. Endocrinol, vol.23, pp.167-176, 1999. ,
An aromatase inhibitor or high water temperature induce oocyte apoptosis and depletion of P450 aromatase activity in the gonads of genetic female zebrafish during sex-reversal, Comp. Biochem. Physiol. Part A Mol. Integr. Physiol, vol.137, pp.11-20, 2004. ,
Characterization and expression profile of the ovarian cytochrome P-450 aromatase (cyp19A1) gene during thermolabile sex determination in pejerrey, Odontesthes bonariensis, J. Exp. Zool. Part A Ecol. Genet. Physiol, vol.307, pp.625-636, 2007. ,
Sex differentiation and sex change in the protandrous black porgy, Acanthopagrus schlegeli, Gen. Comp. Endocrinol, vol.167, pp.417-421, 2010. ,
Molecular mechanisms underlying sex change in hermaphroditic groupers, Fish Physiol Biochem, vol.36, pp.181-193, 2010. ,
The Reversible Sex of Gonochoristic Fish: Insights and Consequences, Sex. Dev, vol.10, pp.242-266, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01954188
Epigenetic modification and inheritance in sexual reversal of fish, Genome Res, 2014. ,
Sex-and tissue-specific expression of P450 aromatase (cyp19a1a) in the yellowtail clownfish, Amphiprion clarkii, Comp. Biochem. Physiol. Part A Mol. Integr. Physiol, vol.155, pp.237-244, 2010. ,
Epigenetics of sex determination and gonadogenesis, Dev Dyn, vol.242, pp.360-370, 2013. ,
Temperature-Dependent Sex Determination in Fish Revisited: Prevalence, a Single Sex Ratio Response Pattern and Possible Effects of Climate Change, PLoS One, vol.3, p.2837, 2008. ,
Sexual determination and differentiation in teleost fish, Rev. Fish Biol. Fish, vol.20, pp.101-121, 2009. ,
Characterization of Luteinizing Hormone and Luteinizing Hormone Receptor and Their Indispensable Role in the Ovulatory Process of the Medaka, PLoS One, vol.8, p.54482, 2013. ,
Sexual Dimorphic Expression of Genes in Gonads During Early Differentiation of a Teleost Fish, the Nile Tilapia Oreochromis niloticus, Biol. Reprod, vol.78, pp.333-341, 2008. ,
Expression profiling of candidate genes during ovary-to-testis transdifferentiation in rainbow trout masculinized by androgens, Gen. Comp. Endocrinol, vol.156, pp.369-378, 2008. ,
Retinoic acid metabolic genes, meiosis and gonadal sex differentiation in zebrafish, PLoS One, vol.8, 2013. ,
Retinoic acid homeostasis through aldh1a2 and cyp26a1 mediates meiotic entry in Nile tilapia, Oreochromis niloticus). Sci. Rep, vol.5, p.10131, 2015. ,
, SCIenTIfIC RePoRTS |, vol.8, p.3564, 2018.
High temperature induces cyp26b1 mRNA expression and delays meiotic initiation of germ cells by increasing cortisol levels during gonadal sex differentiation in Japanese flounder, Biochem. Biophys. Res. Commun, vol.419, pp.287-292, 2012. ,
Growth differentiation factor-9 is required during early ovarian folliculogenesis, Nature, vol.383, pp.531-535, 1996. ,
Sexually dimorphic expression of a teleost homologue of Mu?llerian inhibiting substance during gonadal sex differentiation in Japanese flounder, Paralichthys olivaceus, Biochem. Biophys. Res. Commun, vol.322, pp.508-513, 2004. ,
Zebrafish sex determination and differentiation: involvement of FTZ-F1 genes, Reprod Biol Endocrinol, vol.3, p.63, 2005. ,
Characterization of Sex Determination and Sex Differentiation Genes in Latimeria, PLoS One, vol.8, p.56006, 2013. ,
Sox genes find their feet, Curr. Opin. Genet. Dev, vol.7, pp.338-344, 1997. ,
Identification of SOX3 as an XX male sex reversal gene in mice and humans, J. Clin. Invest, vol.121, pp.328-341, 2011. ,
Sox3 expression in undifferentiated spermatogonia is required for the progression of spermatogenesis, Dev. Biol, vol.283, pp.215-225, 2005. ,
Quantitative mRNA expression of sox3 and DMRT1 during sex reversal and expression profiles after GnRHa administration in black porgy, Acanthopagrus schlegeli. Comp. Biochem. Physiol. Part B Biochem. Mol. Biol, vol.154, pp.150-156, 2009. ,
Differential expression and dynamic changes of SOX3 during gametogenesis and sex reversal in protogynous hermaphroditic fish, J. Exp. Zool. Part A Ecol. Genet. Physiol, vol.307, pp.207-219, 2007. ,
The SOX gene family: function and regulation in testis determination and male fertility maintenance, Mol. Biol. Rep, vol.40, pp.2187-2194, 2013. ,
sox9 in a teleost fish, medaka (Oryzias latipes): Evidence for diversified function of Sox9 in gonad differentiation, Mol. Reprod. Dev, vol.63, pp.5-16, 2002. ,
Two Sox9 Genes on Duplicated Zebrafish Chromosomes: Expression of Similar Transcription Activators in Distinct Sites, Dev. Biol, vol.231, pp.149-163, 2001. ,
Evidence for evolutionary conservation of sex-determining genes, Nature, vol.391, pp.691-695, 1998. ,
Dmrt1 genes at the crossroads: a widespread and central class of sexual development factors in fish, FEBS J, vol.278, pp.1010-1019, 2011. ,
Dmrt genes in the development and evolution of sexual dimorphism, Trends Genet, vol.28, pp.175-184, 2012. ,
Zebrafish Dmrta2 regulates neurogenesis in the telencephalon, Genes to Cells, vol.16, pp.1097-1109, 2011. ,
Left-Right Function of dmrt2 Genes Is Not Conserved between Zebrafish and Mouse, PLoS One, vol.5, p.14438, 2011. ,
Sex dimorphic expression of five dmrt genes identified in the Atlantic cod genome. The fish-specific dmrt2b diverged from dmrt2a before the fish whole-genome duplication, Gene, vol.505, pp.221-232, 2012. ,
DMRT1 expression during gonadal differentiation and spermatogenesis in the rainbow trout, Oncorhynchus mykiss, Biochim. Biophys. Acta -Gene Struct. Expr, vol.1493, pp.180-187, 2000. ,
Expression and phylogeny of candidate genes for sex differentiation in a primitive fish species, the Siberian sturgeon, Acipenser baerii, Mol. Reprod. Dev, vol.79, pp.504-516, 2012. ,
Dimorphic Expression of dmrt1and cyp19a1 (Ovarian Aromatase) during Early Gonadal Development in Pejerrey, Odontesthes bonariensis, Sex. Dev, vol.2, pp.316-324, 2008. ,
The roles of Dmrt (Double sex/Male-abnormal-3 Related Transcription factor) genes in sex determination and differentiation mechanisms: Ubiquity and diversity across the animal kingdom, C. R. Biol, vol.338, pp.451-462, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-01163079
Role of steriod hormones in sex change of protogynous wrasse, Fish Physiol. Biochem, vol.28, pp.149-150, 2003. ,
Current Status of Genetic and Endocrine Factors in the Sex Change of Protandrous Black Porgy, Acanthopagrus schlegeli (Teleostean), Ann. N. Y. Acad. Sci, vol.1040, pp.206-214, 2005. ,
, Guidelines for the treatment of animals in behavioural research and teaching, Anim. Behav, vol.53, pp.229-234, 1997.
on the protection of animals used for scientific purposes, vol.22, 2010. ,
Ethical justification for the use and treatment of fishes in research: an update, J. Fish Biol, vol.78, pp.393-394, 2011. ,
5S rRNA and Accompanying Proteins in Gonads: Powerful Markers to Identify Sex and Reproductive Endocrine Disruption in Fish, Environ. Sci. Technol, vol.46, pp.7763-7771, 2012. ,
Ribosome RNA Profiling to Quantify Ovarian Development and Identify Sex in, Fish. Sci. Rep, vol.7, p.4196, 2017. ,
,
,
,
Trimmomatic: a flexible trimmer for Illumina sequence data, Bioinformatics, vol.30, 2014. ,
Quality control and preprocessing of metagenomic datasets, Bioinformatics, 2011. ,
Trinity: reconstructing a full-length transcriptome without a genome from RNA-Seq data, Nat. Biotechnol, vol.29, pp.644-652, 2011. ,
RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome, BMC Bioinformatics, vol.12, 2011. ,
De novo transcript sequence reconstruction from RNA-seq using the Trinity platform for reference generation and analysis, Nat. Protoc, vol.8, pp.1494-1512, 2013. ,
The Sequence Alignment/Map format and SAMtools, Bioinformatics, vol.25, 2009. ,
BUSCO: assessing genome assembly and annotation completeness with single-copy orthologs, Bioinformatics, 2015. ,
Basic local alignment search tool, J. Mol. Biol, vol.215, pp.403-410, 1990. ,
New Options for BLAST and a Java Application Manager for BLAST results, Bioinformatics, vol.25, pp.824-826, 2009. ,
InterPro: the integrative protein signature database, Nucleic Acids Res, vol.37, pp.211-215, 2009. ,
URL : https://hal.archives-ouvertes.fr/hal-01214141
EMBOSS: The European Molecular Biology Open Software Suite, Trends Genet, vol.16, pp.276-277, 2016. ,
Additional Gene Ontology structure for improved biological reasoning, Bioinformatics, vol.22, pp.2020-2027, 2006. ,
,
Kyoto Encyclopedia of Genes and Genomes, Nucleic Acids Res, vol.28, pp.27-30, 2000. ,
, SCIenTIfIC RePoRTS |, vol.8, p.3564, 2018.
Independent filtering increases detection power for high-throughput experiments, Proc. Natl. Acad. Sci. USA, vol.107, pp.9546-9551, 2010. ,
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq. 2, Genome Biol, vol.15, 2014. ,
Bioconductor: open software development for computational biology and bioinformatics, Genome Biol, vol.5, 2004. ,
Principal component analysis, 2002. ,
gplots: Various R programming tools for plotting data. R Packag, 2009. ,
, Nucleic Acids Res, 2015.
The use of gene clusters to infer functional coupling, Proc. Natl. Acad. Sci. USA, vol.96, pp.2896-2901, 1999. ,