Skip to Main content Skip to Navigation
Journal articles

Comprehensive preterm breast milk metabotype associated with optimal infant early growth pattern

Abstract : Early nutrition impacts preterm infant early growth rate and brain development but can have long lasting effects as well. Although human milk is the gold standard for feeding new born full-term and preterm infants, little is known about the effects of its bioactive compounds on breastfed preterm infants' growth outcomes. This study aims to determine whether breast milk metabolome, glycome, lipidome, and free-amino acids profiles analyzed by liquid chromatography-mass spectrometry had any impact on the early growth pattern of preterm infants. The study population consisted of the top tercile-Z score change in their weight between birth and hospital discharge ("faster grow", n = 11) and lowest tercile ("slower grow", n = 15) from a cohort of 138 premature infants (27⁻34 weeks gestation). This holistic approach combined with stringent clustering or classification statistical methods aims to discriminate groups of milks phenotype and identify specific metabolites associated with early growth of preterm infants. Their predictive reliability as biomarkers of infant growth was assessed using multiple linear regression and taking into account confounding clinical factors. Breast-milk associated with fast growth contained more branched-chain and insulino-trophic amino acid, lacto-N-fucopentaose, choline, and hydroxybutyrate, pointing to the critical role of energy utilization, protein synthesis, oxidative status, and gut epithelial cell maturity in prematurity.
Complete list of metadata

Cited literature [77 references]  Display  Hide  Download

https://hal.inrae.fr/hal-02620327
Contributor : Migration Prodinra <>
Submitted on : Monday, May 25, 2020 - 10:15:31 PM
Last modification on : Tuesday, September 7, 2021 - 3:36:11 PM

File

2019_Nutrients_Alexandre-Gouab...
Publisher files allowed on an open archive

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Collections

Citation

Marie Cécile Alexandre-Gouabau, Thomas Moyon, Agnes Sochard, François Fenaille, Sophie Cholet, et al.. Comprehensive preterm breast milk metabotype associated with optimal infant early growth pattern. Nutrients, MDPI, 2019, 11 (3), pp.1-26. ⟨10.3390/nu11030528⟩. ⟨hal-02620327⟩

Share

Metrics

Record views

90

Files downloads

183