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Extreme ultraviolet radiation: A mans of Ion activation for tandem mass spectrometry

Abstract : Tandem mass spectrometry has long been established as a corner stone of analytical and structural chemistry. Fast radical-directed dissociation, produced by electron-transfer and electron-capture dissociation (ETD and ECD) has been shown to provide important complementary information to collision-induced dissociation (CID). We report the first application of extreme-ultraviolet (XUV) lamps to tandem mass spectrometry. These discharge lamps are versatile, robust, and low-cost sources of energetic photons (40-80 nm). The coupling of the discharge lamp with a Waters Synapt G2-Si Q-ToF mass spectrometer is achieved through a specific trapping scheme in the TriWave region of the instrument, allowing efficient irradiation of the precursor ions. Rich radical-directed dissociation was produced for a number of model compounds, providing unique, complementary information to existing dissociation techniques.
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Alexandre Giuliani, Jonathan P. Williams, Martin R. Green. Extreme ultraviolet radiation: A mans of Ion activation for tandem mass spectrometry. Analytical Chemistry, American Chemical Society, 2018, 90 (12), pp.7176-7180. ⟨10.1021/acs.analchem.8b01789⟩. ⟨hal-02621927⟩



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