mRNA vaccines -a new era in vaccinology, Nat. Rev. Drug Discov, vol.17, pp.261-279, 2018. ,
New vaccine technologies to combat outbreak situations, Front. Immunol, vol.9, 1963. ,
Advancements in DNA vaccine vectors, non-mechanical delivery methods, and molecular adjuvants to increase immunogenicity, Hum Vaccin Immunother, vol.13, pp.2837-2848, 2017. ,
DNA vaccines-How far from clinical use?, Int. J. Mol. Sci, vol.19, 2018. ,
Sung, Clearance of persistent HPV infection and cervical lesion by therapeutic DNA vaccine in CIN3 patients, Nat. Commun, vol.5, p.5317, 2014. ,
Prime boost immunisations with DNA, MVA and protein-based vaccines elicit robust HIV-1, Tier 2 neutralizing antibodies against the CAP256 superinfecting virus, J. Virol, vol.93, 2019. ,
Safety and immunogenicity of an anti-Zika virus DNA vaccine -preliminary report, N. Engl. J. Med, 2017. ,
Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2/3: a randomised, double-blind, Lancet, vol.386, pp.2078-2088, 2015. ,
DNA vaccination for finfish aquaculture, Fish Shellfish Immunol, vol.85, pp.106-125, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-02624534
Using plasmids as DNA vaccines for infectious diseases, Microbiol Spectr, vol.2, 2014. ,
The origins of the vaccine cold chain and a glimpse of the future, Vaccine, vol.35, pp.2115-2120, 2017. ,
Technologies for enhanced efficacy of DNA vaccines, Expert Rev Vaccines, vol.11, pp.189-209, 2012. ,
What you always needed to know about electroporation based DNA vaccines, Hum Vaccin Immunother, vol.8, pp.1694-1702, 2012. ,
Delineating the cell death mechanisms associated with skin electroporation, Hum Gene Ther Methods, vol.29, pp.177-188, 2018. ,
Dual therapeutic benefit of electroporationmediated DNA vaccination in vivo: enhanced gene transfer and adjuvant activity, Oncoimmunology, vol.3, p.28540, 2014. ,
Increased gene expression and inflammatory cell infiltration caused by electroporation are both important for improving the efficacy of DNA vaccines, J. Biotechnol, vol.110, pp.1-10, 2004. ,
Electroporation as a vaccine delivery system and a natural adjuvant to intradermal administration of plasmid DNA in macaques, Sci. Rep, vol.7, p.4122, 2017. ,
URL : https://hal.archives-ouvertes.fr/inserm-02437890
Improved genetic immunization via micromechanical disruption of skin-barrier function and targeted epidermal delivery, Nat. Med, vol.8, pp.415-419, 2002. ,
Cutaneous vaccination using microneedles coated with hepatitis C DNA vaccine, Gene Ther, vol.17, pp.811-814, 2010. ,
The success of microneedle-mediated vaccine delivery into skin, Hum Vaccin Immunother, vol.12, pp.2975-2983, 2016. ,
DNA vaccination for cervical cancer: strategic optimisation of RALA mediated gene delivery from a biodegradable microneedle system, Eur. J. Pharm. Biopharm, vol.127, pp.288-297, 2018. ,
Rabies vaccination in dogs using a dissolving microneedle patch, J. Control. Release, vol.239, pp.19-26, 2016. ,
Vaccine delivery to the oral cavity using coated microneedles induces systemic and mucosal immunity, Pharm. Res, vol.31, pp.2393-2403, 2014. ,
Production of dissolvable microneedles using an atomised spray process: effect of microneedle composition on skin penetration, Eur. J. Pharm. Biopharm, vol.86, pp.200-211, 2014. ,
Hydrodynamic gene delivery in human skin using a hollow microneedle device, J. Control. Release, vol.265, pp.120-131, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01764681
DNAbased vaccination against hepatitis B virus using dissolving microneedle arrays adjuvanted by cationic liposomes and CpG ODN, Drug Deliv, vol.23, pp.2391-2398, 2016. ,
Induction of broad immunity by thermostabilised vaccines incorporated in dissolvable microneedles using novel fabrication methods, J. Control. Release, vol.225, pp.192-204, 2016. ,
The pig as an experimental animal model of percutaneous permeation in man: qualitative and quantitative observations-an overview, Skin Pharmacol. Appl. Ski. Physiol, vol.13, pp.229-234, 2000. ,
Pig skin includes dendritic cell subsets transcriptomically related to human CD1a and CD14 dendritic cells presenting different migrating behaviors and T cell activation capacities, J. Immunol, vol.193, pp.5883-5893, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-01194094
Porcine reproductive and respiratory syndrome virus (PRRSV): pathogenesis and interaction with the immune system, Annu. Rev. Anim. Biosci, vol.4, pp.129-154, 2016. ,
Microneedle-mediated transcutaneous immunization with plasmid DNA coated on cationic PLGA nanoparticles, J. Control. Release, vol.163, pp.230-239, 2012. ,
In vivo electroporation enhances the potency of poly-lactide co-glycolide (PLG) plasmid DNA immunization, Vaccine, vol.28, pp.7852-7864, 2010. ,
Aminopeptidase N is a major receptor for the entero-pathogenic coronavirus TGEV, Nature, vol.357, pp.417-420, 1992. ,
Enhanced protective response and immuno-adjuvant effects of porcine GM-CSF on DNA vaccination of pigs against Aujeszky's disease virus, Vet. Immunol. Immunopathol, vol.70, pp.277-287, 1999. ,
In vivo targeting of porcine reproductive and respiratory syndrome virus antigen through porcine DC-SIGN to dendritic cells elicits antigen-specific CD4T cell immunity in pigs, Vaccine, vol.32, pp.6768-6775, 2014. ,
A universal influenza vaccine can Lead to disease exacerbation or viral control depending on delivery strategies, Front. Immunol, vol.7, p.641, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-01569908
A Rift Valley fever virus Gn ectodomain-based DNA vaccine induces a partial protection not improved by APC targeting, NPJ Vaccines, vol.3, p.14, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-02629280
The respiratory DC/macrophage network at steady-state and upon influenza infection in the swine biomedical model, Mucosal Immunol, vol.9, pp.835-849, 2016. ,
URL : https://hal.archives-ouvertes.fr/hal-02394068
Antigen targeting to human HLA class II molecules increases efficacy of DNA vaccination, J. Immunol, vol.197, pp.3575-3585, 2016. ,
Coated microneedle arrays for transcutaneous delivery of live virus vaccines, J. Control. Release, vol.159, pp.34-42, 2012. ,
Enhancing DNA delivery into the skin with a motorized microneedle device, Eur. J. Pharm. Sci, vol.52, pp.215-222, 2014. ,
Characterization of dendritic cells subpopulations in skin and afferent lymph in the swine model, PLoS One, vol.6, p.16320, 2011. ,
Characterization and Transcriptomic analysis of porcine blood conventional and Plasmacytoid dendritic cells reveals striking species-specific differences, J. Immunol, vol.197, pp.4791-4806, 2016. ,
Dendritic cells display subset and tissue-specific maturation dynamics over human life, Immunity, vol.46, pp.504-515, 2017. ,
CD13 regulates dendritic cell cross-presentation and T cell responses by inhibiting receptor-mediated antigen uptake, J. Immunol, vol.188, pp.5489-5499, 2012. ,
Dendritic cell-targeted porcine reproductive and respiratory syndrome virus (PRRSV) antigens adjuvanted with polyinosinic-polycytidylic acid (poly (I:C)) induced non-protective immune responses against heterologous type 2 PRRSV challenge in pigs, Vet. Immunol. Immunopathol, vol.190, pp.18-25, 2017. ,
Proteome-wide screening of the European porcine reproductive and respiratory syndrome virus reveals a broad range of T cell antigen reactivity, Vaccine, vol.32, pp.6828-6837, 2014. ,
The minipig as nonrodent species in toxicology-where are we now?, Int. J. Toxicol, vol.31, pp.507-528, 2012. ,
Poly[di(carboxylatophenoxy)phosphazene] is a potent adjuvant for intradermal immunization, Proc. Natl. Acad. Sci. U. S. A, vol.106, pp.18936-18941, 2009. ,
The immunology of the porcine skin and its value as a model for human skin, Mol. Immunol, vol.66, pp.14-21, 2015. ,
The porcine innate immune system: an update, Dev. Comp. Immunol, vol.45, pp.321-343, 2014. ,
An in-depth comparison of the porcine, murine and human inflammasomes; lessons from the porcine genome and transcriptome, Vet. Microbiol, vol.202, pp.2-15, 2017. ,
The porcine translational research database: a manually curated, genomics and proteomics-based research resource, BMC Genomics, vol.18, p.643, 2017. ,
,
, Analyses of pig genomes provide insight into porcine demography and evolution, pp.393-398, 2012.
URL : https://hal.archives-ouvertes.fr/cea-00880676
Pig bone marrow-derived macrophages resemble human macrophages in their response to bacterial lipopolysaccharide, J. Immunol, vol.188, pp.3382-3394, 2012. ,
The mononuclear phagocyte system of the pig as a model for understanding human innate immunity and disease, J. Leukoc. Biol, vol.89, pp.855-871, 2011. ,
Nanopatch-targeted skin vaccination against West Nile Virus and Chikungunya virus in mice, Small, vol.6, pp.1776-1784, 2010. ,
DNA vaccination strategy targets epidermal dendritic cells, initiating their migration and induction of a host immune response, Mol. Ther. Methods Clin. Dev, vol.1, p.14054, 2014. ,
Skin transfection patterns and expression kinetics of electroporation-enhanced plasmid delivery using the CELLECTRA-3P, a portable next-generation dermal electroporation device, Hum Gene Ther Methods, vol.26, pp.134-146, 2015. ,
Transcending epithelial and intracellular biological barriers; a prototype DNA delivery device, J. Control. Release, vol.226, pp.238-247, 2016. ,
A Hitchhiker's guide to myeloid cell subsets: practical implementation of a novel mononuclear phagocyte classification system, Front. Immunol, vol.6, p.406, 2015. ,
, Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors, vol.356, 2017.
Uncovering the mysteries of Langerhans cells, inflammatory dendritic epidermal cells, and monocyte-derived Langerhans cell-like cells in the epidermis, Front. Immunol, vol.9, p.1768, 2018. ,
Human in vivo-differentiated monocyte-derived dendritic cells, Semin. Cell Dev. Biol, vol.86, pp.44-49, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-02079402
A guide to IL-1 family cytokines in adjuvanticity, FEBS J, vol.285, pp.2377-2401, 2018. ,
Microneedle array design determines the induction of protective memory CD8+ T cell responses induced by a recombinant live malaria vaccine in mice, PLoS One, vol.6, p.22442, 2011. ,
Microneedle-mediated immunization of an adenovirus-based malaria vaccine enhances antigen-specific antibody immunity and reduces anti-vector responses compared to the intradermal route, Sci. Rep, vol.4, p.6154, 2014. ,
Hepatitis B surface antigen incorporated in dissolvable microneedle array patch is antigenic and thermostable, Biomaterials, vol.145, pp.256-265, 2017. ,
Effective and lesion-free cutaneous influenza vaccination, Proc. Natl. Acad. Sci. U. S. A, vol.112, pp.5005-5010, 2015. ,
Safety, tolerability, acceptability and immunogenicity of an influenza vaccine delivered to human skin by a novel high-density microprojection array patch (Nanopatch), Vaccine, vol.36, pp.3779-3788, 2018. ,
Imiquimod: mode of action, Br. J. Dermatol, vol.157, issue.2, pp.8-13, 2007. ,
Adjuvants for porcine reproductive and respiratory syndrome virus vaccines, Vet. Immunol. Immunopathol, vol.129, pp.1-13, 2009. ,
Electroporation improves the immune response induced by a DNA vaccine against pseudorabies virus glycoprotein B in pigs, Res. Vet. Sci, vol.93, pp.1032-1035, 2012. ,
Protection of pigs against Aujeszky's disease by DNA vaccination, J Gen Virol, vol.78, pp.2139-2146, 1997. ,
Foot-and-mouth disease virus neutralizing antibodies production induced by pcDNA3 and Sindbis virus based plasmid encoding FMDV P1-2A3C3D in swine, Antivir. Res, vol.83, pp.45-52, 2009. ,
URL : https://hal.archives-ouvertes.fr/hal-00404759
Dramatic improvement in FMD DNA vaccine efficacy and cross-serotype antibody induction in pigs following a protein boost, Vaccine, vol.26, pp.2647-2656, 2008. ,
Predicted peptides from non-structural proteins of porcine reproductive and respiratory syndrome virus are able to induce IFN-gamma and IL-10, Viruses, vol.5, pp.663-677, 2013. ,
Increased pathogenicity of European porcine reproductive and respiratory syndrome virus is associated with enhanced adaptive responses and viral clearance, Vet. Microbiol, vol.163, pp.13-22, 2013. ,
Unmodified mRNA in LNPs constitutes a competitive technology for prophylactic vaccines, NPJ Vaccines, vol.2, p.29, 2017. ,
Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination, Nature, vol.543, pp.248-251, 2017. ,
Adjuvant effects of a sequence-engineered mRNA vaccine: translational profiling demonstrates similar human and murine innate response, J. Transl. Med, vol.15, p.1, 2017. ,
, Journal of Controlled Release, vol.308, pp.14-28, 2019.