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Article Dans Une Revue Ophthalmologica Année : 2019

Causative pathogens of endophthalmitis after intravitreal anti-vegf injection: an international multicenter study

Shai Cohen
  • Fonction : Auteur
Zafer Cebeci
  • Fonction : Auteur
Dinah Zur
  • Fonction : Auteur

Résumé

Purpose: The main objective of this study was to investigate the microbiological spectrum of endophthalmitis after anti-VEGF injections and to compare streptococcal with non-streptococcus-associated cases with regard to baseline characteristics and injection procedure. Methods: Retrospective, international multicenter study of patients with culture-positive endophthalmitis after intravitreal anti-VEGF injection at 17 different retina referral centers. Results: Eighty-three cases with 87 identified pathogens were included. Coagulase-negative staphylococci (59%) and viridans streptococci (15%) were the most frequent pathogens found. The use of postoperative antibiotics and performance of injections in an operating room setting significantly reduced the rate of streptococcus-induced endophthalmitis cases (= 0.01 for both). Conclusion: We found a statistically significant lower rate of postinjectional local antibiotic therapy and operating room-based procedures among the streptococcus-induced cases compared to cases caused by other organisms.

Dates et versions

hal-02623956 , version 1 (26-05-2020)

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Citer

Catharina Busch, Matias Iglicki, Mali Okada, Pierre Henry Gabrielle, Shai Cohen, et al.. Causative pathogens of endophthalmitis after intravitreal anti-vegf injection: an international multicenter study. Ophthalmologica, 2019, 241 (4), pp.211-219. ⟨10.1159/000496942⟩. ⟨hal-02623956⟩
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