M. A. Mendez, C. A. Monteiro, and B. M. Popkin, Overweight exceeds underweight among women in most developing countries, Am J Clin Nutr, vol.81, pp.714-735, 2005.

S. C. Fisher, S. Y. Kim, A. J. Sharma, R. Rochat, and B. Morrow, Is obesity still increasing among pregnant women? Prepregnancy obesity trends in 20 states, Prev Med, vol.56, pp.372-380, 2003.

R. Devlieger, K. Benhalima, P. Damm, A. Van-assche, C. Mathieu et al., Maternal obesity in Europe: where do we stand and how to move forward?: A scientific paper commissioned by the European Board and College of Obstetrics and Gynaecology (EBCOG), Eur J Obstet Gynecol Reprod Biol, vol.201, pp.203-211, 2016.

Z. Wang, P. Wang, H. Liu, X. He, J. Zhang et al., Maternal adiposity as an independent risk factor for pre-eclampsia: a meta-analysis of prospective cohort studies, Obes Rev, vol.14, pp.508-529, 2013.

H. M. Salihu, D. Cruz, C. Rahman, S. August, and E. M. , Does maternal obesity cause preeclampsia? A systematic review of the evidence, Minerva Ginecol, vol.64, pp.259-80, 2012.

D. Mitanchez and P. Chavatte-palmer, Review shows that maternal obesity induces serious adverse neonatal effects and is associated with childhood obesity in their offspring, Acta Paediatrica, vol.107, issue.7, pp.1156-1165, 2018.
URL : https://hal.archives-ouvertes.fr/hal-02625286

M. R. Torloni, A. P. Betran, B. L. Horta, M. U. Nakamura, A. N. Atallah et al., Prepregnancy BMI and the risk of gestational diabetes: a systematic review of the literature with meta-analysis

, Obes Rev, vol.10, pp.194-203, 2009.

E. Oteng-ntim, J. Kopeika, P. Seed, S. Wandiembe, and P. Doyle, Impact of obesity on pregnancy outcome in different ethnic groups: calculating population attributable fractions, PLoS One, vol.8, p.53749, 2013.

P. M. Catalano, H. D. Mcintyre, J. K. Cruickshank, D. R. Mccance, A. R. Dyer et al., The hyperglycemia and adverse pregnancy outcome study: associations of GDM and obesity with pregnancy outcomes, Diabetes Care, vol.35, pp.780-786, 2012.

S. K. Abell, J. A. Boyle, B. De-courten, G. Soldatos, E. M. Wallace et al., Impact of type 2 diabetes, obesity and glycaemic control on pregnancy outcomes, Aust N Z J Obstet Gynaecol, vol.57, pp.308-322, 2017.

O. Langer, Y. Yogev, E. M. Xenakis, and L. Brustman, Overweight and obese in gestational diabetes: the impact on pregnancy outcome, Am J Obstet Gynecol, vol.192, pp.1768-76, 2005.

M. A. Faucher and M. K. Barger, Gestational weight gain in obese women by class of obesity and select maternal/newborn outcomes: A systematic review, Women Birth, vol.28, pp.70-79, 2015.

M. A. Faucher, M. Hastings-tolsma, J. J. Song, D. S. Willoughby, and S. G. Bader, International Weight Management in Pregnancy Collaborative G. Effect of diet and physical activity based interventions in pregnancy on gestational weight gain and pregnancy outcomes: meta-analysis of individual participant data from randomised trials, BJOG, vol.123, p.3119, 2016.

M. Agha, R. A. Agha, and J. Sandall, Interventions to reduce and prevent obesity in pre-conceptual and pregnant women: a systematic review and meta-analysis, PLoS One, vol.9, p.95132, 2014.

X. Y. Yi, Q. F. Li, J. Zhang, and Z. H. Wang, A meta-analysis of maternal and fetal outcomes of pregnancy after bariatric surgery, Int J Gynaecol Obstet, vol.130, pp.3-9, 2015.

P. Liu, L. Xu, Y. Wang, Y. Zhang, Y. Du et al., Association between perinatal outcomes and maternal pre-pregnancy body mass index, Obes Rev, vol.17, pp.1091-102, 2016.

L. Gaudet, Z. M. Ferraro, S. W. Wen, and M. Walker, Maternal obesity and occurrence of fetal macrosomia: a systematic review and meta-analysis, Biomed Res Int, p.640291, 2014.

Z. Yu, S. Han, J. Zhu, X. Sun, C. Ji et al., Pre-pregnancy body mass index in relation to infant birth weight and offspring overweight/obesity: a systematic review and meta-analysis, PLoS One, vol.8, p.61627, 2013.

N. Heslehurst, H. Simpson, L. J. Ells, J. Rankin, J. Wilkinson et al., The impact of maternal BMI status on pregnancy outcomes with immediate short-term obstetric resource implications: a meta-analysis, Obes Rev, vol.9, pp.635-83, 2008.

S. Dzakpasu, J. Fahey, R. S. Kirby, S. C. Tough, B. Chalmers et al., Contribution of prepregnancy body mass index and gestational weight gain to adverse neonatal outcomes: population attributable fractions for Canada, BMC Pregnancy Childbirth, vol.15, p.21, 2015.

S. D. Mcdonald, Z. Han, S. Mulla, and J. Beyene, Overweight and obesity in mothers and risk of preterm birth and low birth weight infants: systematic review and meta-analyses, Bmj, vol.341, p.3428, 2010.

V. Flenady, L. Koopmans, P. Middleton, J. F. Froen, G. C. Smith et al., Major risk factors for stillbirth in high-income countries: a systematic review and meta-analysis, Lancet, vol.377, pp.1331-1371, 2011.

D. Aune, O. D. Saugstad, T. Henriksen, and S. Tonstad, Maternal body mass index and the risk of fetal death, stillbirth, and infant death: a systematic review and meta-analysis, Jama, vol.311, pp.1536-1582, 2014.

P. W. Tennant, J. Rankin, and R. Bell, Maternal body mass index and the risk of fetal and infant death: a cohort study from the North of England, Hum Reprod, vol.26, pp.1501-1512, 2011.

N. Heslehurst, R. Vieira, L. Hayes, L. Crowe, D. Jones et al., Maternal body mass index and post-term birth: a systematic review and meta-analysis, Obes Rev, vol.18, pp.293-308, 2017.

M. R. Torloni, A. P. Betran, S. Daher, M. Widmer, S. M. Dolan et al., Maternal BMI and preterm birth: a systematic review of the literature with meta-analysis, J Matern Fetal Neonatal Med, vol.22, pp.957-70, 2009.

A. Correa and J. Marcinkevage, Prepregnancy obesity and the risk of birth defects: an update

, Nutr Rev, vol.71, issue.1, pp.68-77, 2013.

K. J. Stothard, P. W. Tennant, R. Bell, and J. Rankin, Maternal overweight and obesity and the risk of congenital anomalies: a systematic review and meta-analysis, Jama, vol.301, pp.636-50, 2009.

M. I. Blomberg and B. Kallen, Maternal obesity and morbid obesity: the risk for birth defects in the offspring, Birth Defects Res A Clin Mol Teratol, vol.88, pp.35-40, 2010.

T. Zhu, J. Tang, F. Zhao, Y. Qu, and D. Mu, Association between maternal obesity and offspring Apgar score or cord pH: a systematic review and meta-analysis, Sci Rep, vol.5, p.18386, 2015.

E. Villamor, K. Tedroff, M. Peterson, S. Johansson, M. Neovius et al., Association Between Maternal Body Mass Index in Early Pregnancy and Incidence of Cerebral Palsy, JAMA, vol.317, pp.925-961, 2017.

M. Blomberg, Maternal obesity, mode of delivery, and neonatal outcome, Obstet Gynecol, vol.122, pp.50-55, 2013.

, Hyperglycaemia and Adverse Pregnancy Outcome (HAPO) Study: associations with maternal body mass index, Bjog, vol.117, pp.575-84, 2010.

D. J. Barker, The fetal and infant origins of adult disease, BMJ, vol.301, p.1111, 1990.

K. M. Godfrey, R. M. Reynolds, S. L. Prescott, M. Nyirenda, V. W. Jaddoe et al., Influence of maternal obesity on the long-term health of offspring, Lancet Diabetes Endocrinol, vol.5, pp.53-64, 2017.

A. A. Mamun, M. Mannan, and S. A. Doi, Gestational weight gain in relation to offspring obesity over the life course: a systematic review and bias-adjusted meta-analysis, Obes Rev, vol.15, pp.338-385, 2014.

T. Sorensen, T. A. Ajslev, L. Angquist, C. S. Morgen, I. G. Ciuchi et al., Comparison of associations of maternal peri-pregnancy and paternal anthropometrics with child anthropometrics Version postprint Comment citer ce document

M. F. Hivert, S. L. Rifas-shiman, M. W. Gillman, and E. Oken, Greater early and mid-pregnancy gestational weight gains are associated with excess adiposity in mid-childhood, Obesity (Silver Spring), vol.24, pp.1546-53, 2016.

S. M. Robinson, S. R. Crozier, N. C. Harvey, B. D. Barton, C. M. Law et al., Modifiable early-life risk factors for childhood adiposity and overweight: an analysis of their combined impact and potential for prevention, Am J Clin Nutr, vol.101, pp.368-75, 2015.

V. Daraki, V. Georgiou, S. Papavasiliou, G. Chalkiadaki, M. Karahaliou et al., Metabolic profile in early pregnancy is associated with offspring adiposity at 4 years of age: the Rhea pregnancy cohort Crete, PLoS One, vol.10, p.126327, 2015.

H. Castillo, I. S. Santos, and A. Matijasevich, Relationship between maternal pre-pregnancy body mass index, gestational weight gain and childhood fatness at 6-7 years by air displacement plethysmography, Matern Child Nutr, vol.11, pp.606-623, 2015.

J. L. Kaar, T. Crume, J. T. Brinton, K. J. Bischoff, R. Mcduffie et al., Maternal obesity, gestational weight gain, and offspring adiposity: the exploring perinatal outcomes among children study, J Pediatr, vol.165, pp.509-524, 2014.

A. J. Oostvogels, K. Stronks, T. J. Roseboom, J. A. Van-der-post, M. Van-eijsden et al.,

, Maternal prepregnancy BMI, offspring's early postnatal growth, and metabolic profile at age 5-6 years: the ABCD Study, J Clin Endocrinol Metab, vol.99, pp.3845-54, 2014.

R. Gaillard, E. A. Steegers, L. Duijts, J. F. Felix, A. Hofman et al., Childhood cardiometabolic outcomes of maternal obesity during pregnancy: the Generation R Study, Hypertension, vol.63, pp.683-91, 2014.

R. Gaillard, E. A. Steegers, O. H. Franco, A. Hofman, and V. W. Jaddoe, Maternal weight gain in different periods of pregnancy and childhood cardio-metabolic outcomes. The Generation R Study, Int J Obes (Lond), vol.39, pp.677-85, 2015.

, Version postprint Comment citer ce document

S. R. Crozier, H. M. Inskip, K. M. Godfrey, C. Cooper, N. C. Harvey et al., Weight gain in pregnancy and childhood body composition: findings from the Southampton Women's Survey, Am J Clin Nutr, vol.91, pp.1745-51, 2010.

A. Fraser, K. Tilling, C. Macdonald-wallis, N. Sattar, M. J. Brion et al., Association of maternal weight gain in pregnancy with offspring obesity and metabolic and vascular traits in childhood, Circulation, vol.121, pp.2557-64, 2010.

L. H. Philipps, S. Santhakumaran, C. Gale, E. Prior, K. M. Logan et al., The diabetic pregnancy and offspring BMI in childhood: a systematic review and meta-analysis, Diabetologia, vol.54, pp.1957-66, 2011.

K. Schellong, S. Schulz, T. Harder, and A. Plagemann, Birth weight and long-term overweight risk: systematic review and a meta-analysis including 643,902 persons from 66 studies and 26 countries globally, PLoS One, vol.7, p.47776, 2012.

C. M. Boney, A. Verma, R. Tucker, and B. R. Vohr, Metabolic syndrome in childhood: association with birth weight, maternal obesity, and gestational diabetes mellitus, Pediatrics, vol.115, pp.290-296, 2005.

J. A. Woo-baidal, L. M. Locks, E. R. Cheng, T. L. Blake-lamb, M. E. Perkins et al., Risk Factors for

, Childhood Obesity in the First 1,000 Days: A Systematic Review, Am J Prev Med, vol.50, pp.761-79, 2016.

P. Chavatte-palmer, A. Tarrade, and D. Rousseau-ralliard, Diet before and during Pregnancy and Offspring Health: The Importance of Animal Models and What Can Be Learned from Them, Int J Environ Res Public Health, vol.13, p.586, 2016.

L. Myatt and A. Maloyan, Obesity and Placental Function, Semin Reprod Med, vol.34, pp.42-51, 2016.

L. Zhang, N. M. Long, S. M. Hein, Y. Ma, P. W. Nathanielsz et al., Maternal obesity in ewes results in reduced fetal pancreatic beta-cell numbers in late gestation and decreased circulating insulin concentration at term, Domest Anim Endocrinol, vol.40, pp.30-39, 2011.

D. Farley, M. E. Tejero, A. G. Comuzzie, P. B. Higgins, L. Cox et al., Feto-placental adaptations to maternal obesity in the baboon, Placenta, vol.30, pp.752-60, 2009.

E. Zambrano, C. Ibanez, P. M. Martinez-samayoa, C. Lomas-soria, M. Durand-carbajal et al., Maternal Obesity: Lifelong Metabolic Outcomes for Offspring from Poor Developmental Trajectories During the Perinatal Period, Arch Med Res, vol.47, pp.1-12, 2016.

U. D. Wankhade, K. M. Thakali, and K. Shankar, Persistent influence of maternal obesity on offspring health: Mechanisms from animal models and clinical studies, Mol Cell Endocrinol, vol.435, pp.7-19, 2016.

A. Tarrade, P. Panchenko, C. Junien, and A. Gabory, Placental contribution to nutritional programming of health and diseases: epigenetics and sexual dimorphism, Front Physiol, vol.218, p.33, 2015.
URL : https://hal.archives-ouvertes.fr/hal-02636923

J. Mao, X. Zhang, P. T. Sieli, M. T. Falduto, K. E. Torres et al., Contrasting effects of different maternal diets on sexually dimorphic gene expression in the murine placenta, Proc Natl Acad Sci U S A, vol.107, pp.5557-62, 2010.

D. Mitanchez, S. Jacqueminet, J. Nizard, M. L. Tanguy, C. Ciangura et al., Effect of maternal obesity on birthweight and neonatal fat mass: A prospective clinical trial, PLoS One, vol.12, p.181307, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01579704

A. J. Watkins, E. S. Lucas, and T. P. Fleming, Impact of the periconceptional environment on the programming of adult disease, J Dev Orig Health Dis, vol.1, pp.87-95, 2010.

M. Dahlhoff, S. Pfister, A. Blutke, J. Rozman, M. Klingenspor et al., Periconceptional obesogenic exposure induces sex-specific programming of disease susceptibilities in adult mouse offspring, Biochim Biophys Acta, vol.1842, pp.304-321, 2014.

K. Shankar, Y. Zhong, P. Kang, F. Lau, M. L. Blackburn et al., Maternal obesity promotes a proinflammatory signature in rat uterus and blastocyst, Endocrinology, vol.152, pp.4158-70, 2011.

I. E. Sasson, A. P. Vitins, M. A. Mainigi, K. H. Moley, and R. A. Simmons, Pre-gestational vs gestational exposure to maternal obesity differentially programs the offspring in mice, Diabetologia, vol.58, pp.615-639, 2015.

P. E. Panchenko, S. Voisin, M. Jouin, L. Jouneau, A. Prezelin et al., Expression of epigenetic machinery genes is sensitive to maternal obesity and weight loss in relation to fetal growth in mice, Clin Epigenetics, vol.8, p.22, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01281980

K. M. Aagaard-tillery, K. Grove, J. Bishop, X. Ke, Q. Fu et al., Developmental origins of disease and determinants of chromatin structure: maternal diet modifies the primate fetal epigenome, J Mol Endocrinol, vol.41, pp.91-102, 2008.

R. A. Waterland, R. Kellermayer, E. Laritsky, P. Rayco-solon, R. A. Harris et al., Season of conception in rural gambia affects DNA methylation at putative human metastable epialleles

, PLoS Genet, vol.6, p.1001252, 2010.

R. A. Waterland, M. Travisano, K. G. Tahiliani, M. T. Rached, and S. Mirza, Methyl donor supplementation prevents transgenerational amplification of obesity, Int J Obes (Lond), vol.32, pp.1373-1382, 2008.

A. Bourdon, P. Parnet, C. Nowak, N. T. Tran, N. Winer et al.,

, Enhances Fetal Growth and Protein Synthesis in Rats with Intrauterine Growth Restriction, J Nutr, vol.146, pp.532-573, 2016.

A. Miczke, J. Suliburska, D. Pupek-musialik, L. Ostrowska, A. Jablecka et al., Effect of L-arginine supplementation on insulin resistance and serum adiponectin concentration in rats with fat diet, Int J Clin Exp Med, vol.8, pp.10358-66, 2015.

J. Suliburska, P. Bogdanski, M. Szulinska, D. Pupek-musialik, and A. Jablecka, Changes in mineral status are associated with improvements in insulin sensitivity in obese patients following L-arginine supplementation, Eur J Nutr, vol.53, pp.387-93, 2014.

M. J. Heerwagen, M. S. Stewart, B. A. De-la-houssaye, R. C. Janssen, and J. E. Friedman, Transgenic increase in N-3/n-6 Fatty Acid ratio reduces maternal obesity-associated inflammation and limits adverse developmental programming in mice, PLoS One, vol.8, 2013.

P. W. Nathanielsz, S. P. Ford, N. M. Long, C. C. Vega, L. A. Reyes-castro et al., Interventions to prevent adverse fetal programming due to maternal obesity during pregnancy, Nutr Rev, p.71, 2013.

E. Navarro, A. N. Funtikova, M. Fito, and H. Schroder, Prenatal nutrition and the risk of adult obesity

, Long-term effects of nutrition on epigenetic mechanisms regulating gene expression, J Nutr Biochem, vol.39, pp.1-14, 2017.

, Figure 1: Summary of the major findings from epidemiological studies on the effect of maternal obesity on pregnancy, fetal development, neonatal outcomes and childhood health

, Interestingly, when it was adjusted for maternal BMI, gestational diabetes had no effect on childhood obesity. In contrast, the combination of maternal obesity and excess maternal weight gain or excess fetal growth increased the risks of childhood obesity and metabolic syndrome, respectively. OR: Odd Ratio Version postprint Comment citer ce document