Ivermectin: a complimentary weapon against the spread of malaria? - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles Expert Review of Anti-infective Therapy Year : 2017

Ivermectin: a complimentary weapon against the spread of malaria?

Abstract

Introduction: Ivermectin has transformed the treatment of parasitic diseases and led to incommensurable benefits to humans and animals. Ivermectin is effective in treating several neglected infectious diseases and recently it has been shown to reduce malaria parasite transmission.Areas covered: Malaria control strategies could benefit from the addition of ivermectin to interrupt the transmission cycle if it is a long lasting formulation or repeatedly administered. In turn, this will help also to control neglected infectious diseases where the elimination goal has been slower to achieve. Despite the relevance of using ivermectin for integrated and sustained disease control, there are still essential questions that remain to be addressed about safety and practicality. The efficacy in various malaria ecologies and the interaction between control tools, either drugs or insecticides, are also important to assess.Expert commentary: Overlapping distribution of several infectious diseases reveals the benefit of integrating control programs against several infectious diseases into one strategy for cost effectiveness and to reach the elimination goals. The use of ivermectin to control malaria transmission will necessitate development and testing of long-lasting formulations or repeated treatments, and implementation of these treatments with other disease control tools may increase the chance of successful and sustained control.

Dates and versions

hal-02625607 , version 1 (26-05-2020)

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Haoues Alout, Brian D. Foy. Ivermectin: a complimentary weapon against the spread of malaria?. Expert Review of Anti-infective Therapy, 2017, 15 (3), pp.231-240. ⟨10.1080/14787210.2017.1271713⟩. ⟨hal-02625607⟩

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