H. Teede, A. Deeks, and L. Moran, Polycystic ovary syndrome: A complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan, BMC Med, vol.8, p.41, 2010.

E. Rotterdam and . Group, Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome, Fertil. Steril, vol.81, pp.19-25, 2004.

H. J. Teede, M. L. Misso, M. F. Costello, A. Dokras, J. Laven et al., Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome, Fertil. Steril, vol.110, pp.364-379, 2018.

K. A. Toulis, D. G. Goulis, D. Farmakiotis, N. A. Georgopoulos, I. Katsikis et al., Adiponectin levels in women with polycystic ovary syndrome: A systematic review and a meta-analysis, Hum. Reprod. Update, vol.15, pp.297-307, 2009.

A. Benrick, B. Chanclon, P. Micallef, Y. Wu, L. Hadi et al., Wernstedt Asterholm, I. Adiponectin protects against development of metabolic disturbances in a PCOS mouse model, Proc. Natl. Acad. Sci, vol.114, pp.7187-7196, 2017.

R. Pasquali, C. Pelusi, S. Genghini, M. Cacciari, and A. Gambineri, Obesity and reproductive disorders in women, Hum. Reprod. Update, vol.9, pp.359-372, 2003.

J. E. Norman, The adverse effects of obesity on reproduction, Reproduction, vol.140, pp.343-345, 2010.

R. Pasquali, A. Gambineri, and U. Pagotto, The impact of obesity on reproduction in women with polycystic ovary syndrome, BJOG, vol.113, pp.1148-1159, 2006.

M. Bluher, Adipose tissue dysfunction in obesity, Exp. Clin. Endocrinol. Diabetes, vol.117, pp.241-250, 2009.

K. Ohashi, R. Shibata, T. Murohara, and N. Ouchi, Role of anti-inflammatory adipokines in obesity-related diseases, Trends. Endocrinol. Metab, vol.25, pp.348-355, 2014.

M. J. Vazquez, A. Romero-ruiz, and M. Tena-sempere, Roles of leptin in reproduction, pregnancy and polycystic ovary syndrome: Consensus knowledge and recent developments, Metabolism, vol.64, pp.79-91, 2015.

D. Landry, F. Cloutier, and L. J. Martin, Implications of leptin in neuroendocrine regulation of male reproduction, Reprod. Biol, vol.13, pp.1-14, 2013.

J. Dupont, X. Pollet-villard, M. Reverchon, N. Mellouk, and R. Levy, Adipokines in human reproduction, Horm. Mol. Biol. Clin. Investig, vol.24, pp.11-24, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01351523

C. Chabrolle, L. Tosca, C. Rame, P. Lecomte, D. Royere et al., Adiponectin increases insulin-like growth factor I-induced progesterone and estradiol secretion in human granulosa cells, Fertil. Steril, vol.92, 1988.

M. Reverchon, M. Cornuau, C. Rame, F. Guerif, D. Royere et al., Chemerin inhibits IGF-1-induced progesterone and estradiol secretion in human granulosa cells, Hum. Reprod, vol.27, pp.1790-1800, 2012.
URL : https://hal.archives-ouvertes.fr/hal-01129643

M. Reverchon, M. Cornuau, C. Rame, F. Guerif, D. Royere et al., Resistin decreases insulin-like growth factor I-induced steroid production and insulin-like growth factor I receptor signaling in human granulosa cells, Fertil. Steril, vol.100, pp.247-255, 2013.
URL : https://hal.archives-ouvertes.fr/hal-01129712

M. Reverchon, M. Cornuau, L. Cloix, C. Rame, F. Guerif et al., Visfatin is expressed in human granulosa cells: Regulation by metformin through AMPK/SIRT1 pathways and its role in steroidogenesis, Mol. Hum. Reprod, vol.19, pp.313-326, 2013.
URL : https://hal.archives-ouvertes.fr/hal-01129746

L. Cloix, M. Reverchon, M. Cornuau, P. Froment, C. Rame et al., Expression and regulation of INTELECTIN1 in human granulosa-lutein cells: Role in IGF-1-induced steroidogenesis through NAMPT, Biol
URL : https://hal.archives-ouvertes.fr/hal-01129870

J. Roche, C. Rame, M. Reverchon, N. Mellouk, M. Cornuau et al., Apelin (APLN) and Apelin Receptor (APLNR) in Human Ovary: Expression, Signaling, and Regulation of Steroidogenesis in Primary Human Luteinized Granulosa Cells, Biol. Reprod, vol.95, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01404550

M. Tang, C. Huang, Y. F. Wang, P. G. Ren, L. Chen et al., CMKLR1 deficiency maintains ovarian steroid production in mice treated chronically with dihydrotestosterone

Q. Wang, J. Y. Kim, K. Xue, J. Y. Liu, A. Leader et al., Chemerin, a novel regulator of follicular steroidogenesis and its potential involvement in polycystic ovarian syndrome, Endocrinology, vol.153, pp.5600-5611, 2012.

B. K. Tan, J. Chen, S. Farhatullah, R. Adya, J. Kaur et al., Insulin and metformin regulate circulating and adipose tissue chemerin, Diabetes, vol.58, pp.1971-1977, 2009.

K. Bozaoglu, D. Segal, K. A. Shields, N. Cummings, J. E. Curran et al., Chemerin is associated with metabolic syndrome phenotypes in a Mexican-American population, J. Clin. Endocrinol. Metab, vol.94, pp.3085-3088, 2009.

I. Munir, H. W. Yen, T. Baruth, R. Tarkowski, R. Azziz et al., Resistin stimulation of 17alpha-hydroxylase activity in ovarian theca cells in vitro: Relevance to polycystic ovary syndrome, J. Clin. Endocrinol. Metab, vol.90, pp.4852-4857, 2005.

D. P. Baldani, L. Skrgatic, M. Kasum, G. Zlopasa, S. Kralik-oguic et al., Altered leptin, adiponectin, resistin and ghrelin secretion may represent an intrinsic polycystic ovary syndrome abnormality, Gynecol. Endocrinol, vol.35, pp.401-405, 2019.

T. F. Chan, Y. L. Chen, H. H. Chen, C. H. Lee, S. B. Jong et al., Increased plasma visfatin concentrations in women with polycystic ovary syndrome, Fertil. Steril, vol.88, pp.401-405, 2007.

D. Panidis, D. Farmakiotis, D. Rousso, I. Katsikis, D. Delkos et al., Plasma visfatin levels in normal weight women with polycystic ovary syndrome, Eur. J. Intern. Med, vol.19, pp.406-412, 2008.

B. K. Tan, R. Adya, S. Farhatullah, J. Chen, H. Lehnert et al., Metformin treatment may increase omentin-1 levels in women with polycystic ovary syndrome, Diabetes, vol.59, pp.3023-3031, 2010.

B. Orlik, P. Madej, A. Owczarek, P. Skalba, J. Chudek et al., Plasma omentin and adiponectin levels as markers of adipose tissue dysfunction in normal weight and obese women with polycystic ovary syndrome, Clin. Endocrinol. (Oxf), vol.81, pp.529-535, 2014.

A. Barbe, A. Bongrani, N. Mellouk, A. Estienne, P. Kurowska et al., Mechanisms of Adiponectin Action in Fertility: An. Overview from Gametogenesis to Gestation in Humans and Animal Models in Normal and Pathological Conditions, Int. J. Mol. Sci, 1920.
URL : https://hal.archives-ouvertes.fr/hal-02120889

Y. Guvenc, A. Var, A. Goker, and N. K. Kuscu, Assessment of serum chemerin, vaspin and omentin-1 levels in patients with polycystic ovary syndrome, J. Int. Med. Res, vol.44, pp.796-805, 2016.

F. Farshchian, F. Ramezani-tehrani, H. Amirrasouli, H. Rahimi-pour, M. Hedayati et al., Visfatin and resistin serum levels in normal-weight and obese women with polycystic ovary syndrome, Int. J. Endocrinol. Metab, vol.12, 2014.

S. Akbarzadeh, S. Ghasemi, M. Kalantarhormozi, I. Nabipour, F. Abbasi et al., Relationship among plasma adipokines, insulin and androgens level as well as biochemical glycemic and lipidemic markers with incidence of PCOS in women with normal BMI, Gynecol. Endocrinol, vol.28, pp.521-524, 2012.

J. J. Kim, Y. M. Choi, M. A. Hong, M. J. Kim, S. J. Chae et al., Serum visfatin levels in non-obese women with polycystic ovary syndrome and matched controls, Obstet. Gynecol. Sci, vol.61, pp.253-260, 2018.

T. Tao, B. Xu, and W. Liu, Ovarian HMW adiponectin is associated with folliculogenesis in women with polycystic ovary syndrome, Reprod. Biol. Endocrinol, issue.11, p.99, 2013.

I. Tsouma, E. Kouskouni, S. Demeridou, M. Boutsikou, D. Hassiakos et al., Correlation of visfatin levels and lipoprotein lipid profiles in women with polycystic ovary syndrome undergoing ovarian stimulation, Gynecol. Endocrinol, vol.30, pp.516-519, 2014.

K. M. Seow, C. C. Juan, Y. P. Hsu, L. T. Ho, Y. Y. Wang et al., Serum and follicular resistin levels in women with polycystic ovarian syndrome during IVF-stimulated cycles, Hum. Reprod, vol.20, pp.117-121, 2005.

, Practice Committee of the American Society for Reproductive Medicine. Prevention and treatment of moderate and severe ovarian hyperstimulation syndrome: A guideline, Fertil. Steril, vol.106, pp.1634-1647, 2016.

S. Li, X. Huang, H. Zhong, Q. Peng, S. Chen et al., Low circulating adiponectin levels in women with polycystic ovary syndrome: An updated meta-analysis, Tumour. Biol, vol.35, pp.3961-3973, 2014.

T. Artimani, M. Saidijam, R. Aflatoonian, M. Ashrafi, I. Amiri et al., Downregulation of adiponectin system in granulosa cells and low levels of HMW adiponectin in PCOS, J. Assist. Reprod. Genet, vol.33, pp.101-110, 2016.

A. O'connor, N. Phelan, T. K. Tun, G. Boran, J. Gibney et al., High-molecular-weight adiponectin is selectively reduced in women with polycystic ovary syndrome independent of body mass index and severity of insulin resistance, J. Clin. Endocrinol. Metab, vol.95, pp.1378-1385, 2010.

D. B. Campos, M. F. Palin, V. Bordignon, and B. D. Murphy, The 'beneficial' adipokines in reproduction and fertility, Intj. Obes, vol.32, pp.223-231, 2008.

L. Patel, A. C. Buckels, I. J. Kinghorn, P. R. Murdock, J. D. Holbrook et al., Resistin is expressed in human macrophages and directly regulated by PPAR gamma activators, Biochem. Biophys. Res. Commun, vol.300, pp.472-476, 2003.

J. N. Fain, P. S. Cheema, S. W. Bahouth, and M. Lloyd-hiler, Resistin release by human adipose tissue explants in primary culture, Biochem. Biophys. Res. Commun, vol.300, pp.674-678, 2003.

D. Panidis, G. Koliakos, A. Kourtis, D. Farmakiotis, T. Mouslech et al., Serum resistin levels in women with polycystic ovary syndrome, Fertil. Steril, vol.81, pp.361-366, 2004.

J. H. Lee, J. L. Chan, N. Yiannakouris, M. Kontogianni, E. Estrada et al., Circulating resistin levels are not associated with obesity or insulin resistance in humans and are not regulated by fasting or leptin administration: Cross-sectional and interventional studies in normal, insulin-resistant, and diabetic subjects, J. Clin. Endocrinol. Metab, vol.88, pp.4848-4856, 2003.

K. M. Seow, C. C. Juan, Y. P. Hsu, J. L. Hwang, L. W. Huang et al., Amelioration of insulin resistance in women with PCOS via reduced insulin receptor substrate-1 Ser312 phosphorylation following laparoscopic ovarian electrocautery, Hum. Reprod, vol.22, pp.1003-1010, 2007.

K. M. Seow, C. C. Juan, L. Y. Wu, Y. P. Hsu, W. M. Yang et al., Serum and adipocyte resistin in polycystic ovary syndrome with insulin resistance, Hum. Reprod, vol.19, pp.48-53, 2004.

B. Samal, Y. Sun, G. Stearns, C. Xie, S. Suggs et al., Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor, Mol. Cell. Biol, vol.14, pp.1431-1437, 1994.

A. Fukuhara, M. Matsuda, M. Nishizawa, K. Segawa, M. Tanaka et al., Visfatin: A protein secreted by visceral fat that mimics the effects of insulin, Science, vol.307, pp.426-430, 2005.

J. Berndt, N. Kloting, S. Kralisch, P. Kovacs, M. Fasshauer et al., Plasma visfatin concentrations and fat depot-specific mRNA expression in humans, Diabetes, vol.54, pp.2911-2916, 2005.

M. P. Chen, F. M. Chung, D. M. Chang, J. C. Tsai, H. F. Huang et al., Elevated plasma level of visfatin/pre-B cell colony-enhancing factor in patients with type 2 diabetes mellitus, J. Clin. Endocrinol. Metab, vol.91, pp.295-299, 2006.

C. J. Shen, E. M. Tsai, J. N. Lee, Y. L. Chen, C. H. Lee et al., The concentrations of visfatin in the follicular fluids of women undergoing controlled ovarian stimulation are correlated to the number of oocytes retrieved, Fertil. Steril, vol.93, pp.1844-1850, 2010.

E. Plati, E. Kouskouni, A. Malamitsi-puchner, M. Boutsikou, G. Kaparos et al., Visfatin and leptin levels in women with polycystic ovaries undergoing ovarian stimulation, Fertil. Steril, vol.94, pp.1451-1456, 2010.

B. K. Tan, J. Chen, J. E. Digby, S. D. Keay, C. R. Kennedy et al., Increased visfatin messenger ribonucleic acid and protein levels in adipose tissue and adipocytes in women with polycystic ovary syndrome: Parallel increase in plasma visfatin, J. Clin. Endocrinol. Metab, vol.91, pp.5022-5028, 2006.

K. H. Choi, B. S. Joo, S. T. Sun, M. J. Park, J. B. Son et al., Administration of visfatin during superovulation improves developmental competency of oocytes and fertility potential in aged female mice, Fertil. Steril, vol.97, pp.1234-1241, 2012.

K. Tatemoto, M. Hosoya, Y. Habata, R. Fujii, T. Kakegawa et al., Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor, Biochem. Biophys. Res. Commun, vol.251, pp.471-476, 1998.

J. Boucher, B. Masri, D. Daviaud, S. Gesta, C. Guigne et al., , vol.146, pp.1764-1771, 2005.

Y. H. Chang, D. M. Chang, K. C. Lin, S. J. Shin, and Y. J. Lee, Visfatin in overweight/obesity, type 2 diabetes mellitus, insulin resistance, metabolic syndrome and cardiovascular diseases: A meta-analysis and systemic review, Diabetes Metab. Res. Rev, vol.27, pp.515-527, 2011.

A. Rak, E. Drwal, C. Rame, K. Knapczyk-stwora, M. Slomczynska et al., Expression of apelin and apelin receptor (APJ) in porcine ovarian follicles and in vitro effect of apelin on steroidogenesis and proliferation through APJ activation and different signaling pathways, Theriogenology, vol.96, pp.126-135, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01529465

K. Shirasuna, T. Shimizu, K. Sayama, T. Asahi, M. Sasaki et al., Expression and localization of apelin and its receptor APJ in the bovine corpus luteum during the estrous cycle and prostaglandin F2alpha-induced luteolysis, Reproduction, vol.135, pp.519-525, 2008.

J. Roche, C. Rame, M. Reverchon, N. Mellouk, A. Rak et al., Apelin (APLN) regulates progesterone secretion and oocyte maturation in bovine ovarian cells, vol.153, pp.589-603, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01607262

T. Shimizu, N. Kosaka, C. Murayama, M. Tetsuka, and A. Miyamoto, Apelin and APJ receptor expression in granulosa and theca cells during different stages of follicular development in the bovine ovary: Involvement of apoptosis and hormonal regulation, Anim. Reprod. Sci, vol.116, pp.28-37, 2009.

S. Franks, J. Stark, and K. Hardy, Follicle dynamics and anovulation in polycystic ovary syndrome, Hum. Reprod. Update, vol.14, pp.367-378, 2008.

S. Taheri, K. Murphy, M. Cohen, E. Sujkovic, A. Kennedy et al., The effects of centrally administered apelin-13 on food intake, water intake and pituitary hormone release in rats, Biochem. Biophys. Res. Commun, vol.291, pp.1208-1212, 2002.

S. O. Altinkaya, S. Nergiz, M. Kucuk, and H. Yuksel, Apelin levels in relation with hormonal and metabolic profile in patients with polycystic ovary syndrome, Eurj. Obstet. Gynecol. Reprod. Biol, vol.176, pp.168-172, 2014.

M. Olszanecka-glinianowicz, P. Madej, M. Nylec, A. Owczarek, W. Szanecki et al., Circulating apelin level in relation to nutritional status in polycystic ovary syndrome and its association with metabolic and hormonal disturbances, Clin. Endocrinol. (Oxf), vol.79, pp.238-242, 2013.

R. Z. Yang, M. J. Lee, H. Hu, J. Pray, H. B. Wu et al., Identification of omentin as a novel depot-specific adipokine in human adipose tissue: Possible role in modulating insulin action, Am. J. Physiol. Endocrinol. Metab, vol.290, pp.1253-1261, 2006.

A. Mahde, M. Shaker, and Z. Al-mashhadani, Study of Omentin1 and Other Adipokines and Hormones in PCOS Patients, Oman. Med. J, vol.24, pp.108-118, 2009.

J. H. Choi, E. J. Rhee, K. H. Kim, H. Y. Woo, W. Y. Lee et al., Plasma omentin-1 levels are reduced in non-obese women with normal glucose tolerance and polycystic ovary syndrome, Eur. J. Endocrinol, vol.165, pp.789-796, 2011.

J. M. Moreno-navarrete, V. Catalan, F. Ortega, J. Gomez-ambrosi, W. Ricart et al., Circulating omentin concentration increases after weight loss, Nutr. Metab

B. K. Tan, S. Pua, F. Syed, K. C. Lewandowski, J. P. O'hare et al., Decreased plasma omentin-1 levels in Type 1 diabetes mellitus, Diabet. Med, vol.25, pp.1254-1255, 2008.

C. M. De-souza-batista, R. Z. Yang, M. J. Lee, N. M. Glynn, D. Z. Yu et al., Omentin plasma levels and gene expression are decreased in obesity, Diabetes, vol.56, pp.1655-1661, 2007.

P. M. Spritzer, S. B. Lecke, F. Satler, and D. M. Morsch, Adipose tissue dysfunction, adipokines, and low-grade chronic inflammation in polycystic ovary syndrome, Reproduction, vol.149, pp.219-227, 2015.

O. De-henau, G. N. Degroot, V. Imbault, V. Robert, C. De-poorter et al., Signaling Properties of Chemerin Receptors CMKLR1, GPR1 and CCRL2, PLoS ONE, vol.11, 2016.

V. Wittamer, J. D. Franssen, M. Vulcano, J. F. Mirjolet, E. Le-poul et al., Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids, J. Exp. Med, vol.198, pp.977-985, 2003.

K. Bozaoglu, K. Bolton, J. Mcmillan, P. Zimmet, J. Jowett et al., Chemerin is a novel adipokine associated with obesity and metabolic syndrome, Endocrinology, vol.148, pp.4687-4694, 2007.

K. B. Goralski, T. C. Mccarthy, E. A. Hanniman, B. A. Zabel, E. C. Butcher et al., Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism, J. Biol. Chem, vol.282, pp.28175-28188, 2007.

D. H. Kort, A. Kostolias, C. Sullivan, and R. A. Lobo, Chemerin as a marker of body fat and insulin resistance in women with polycystic ovary syndrome, Gynecol. Endocrinol, vol.31, pp.152-155, 2015.

C. Tsatsanis, E. Dermitzaki, P. Avgoustinaki, N. Malliaraki, V. Mytaras et al., The impact of adipose tissue-derived factors on the hypothalamic-pituitary-gonadal (HPG) axis. Horm. (Athens), vol.14, pp.549-562, 2015.

J. Y. Kim, K. Xue, M. Cao, Q. Wang, J. Y. Liu et al., Chemerin suppresses ovarian follicular development and its potential involvement in follicular arrest in rats treated chronically with dihydrotestosterone, Endocrinology, vol.154, pp.2912-2923, 2013.

P. D. Lima, A. L. Nivet, Q. Wang, Y. A. Chen, A. Leader et al., Polycystic ovary syndrome: Possible involvement of androgen-induced, chemerin-mediated ovarian recruitment of monocytes/macrophages, Biol. Reprod, vol.99, pp.838-852, 2018.

A. Dunaif, Insulin resistance and the polycystic ovary syndrome: Mechanism and implications for pathogenesis, Endocr. Rev, vol.18, pp.774-800, 1997.

D. Panidis, K. Tziomalos, G. Misichronis, E. Papadakis, G. Betsas et al., Insulin resistance and endocrine characteristics of the different phenotypes of polycystic ovary syndrome: A prospective study, Hum. Reprod, vol.27, pp.541-549, 2012.

D. Dewailly, P. Pigny, B. Soudan, S. Catteau-jonard, C. Decanter et al., Reconciling the definitions of polycystic ovary syndrome: The ovarian follicle number and serum anti-Mullerian hormone concentrations aggregate with the markers of hyperandrogenism, J. Clin. Endocrinol. Metab, vol.95, pp.4399-4405, 2010.

D. Dewailly, M. E. Lujan, E. Carmina, M. I. Cedars, J. Laven et al., Definition and significance of polycystic ovarian morphology: A task force report from the Androgen Excess and Polycystic Ovary Syndrome Society, Hum. Reprod. Update, vol.20, pp.334-352, 2014.

P. Pigny, E. Merlen, Y. Robert, C. Cortet-rudelli, C. Decanter et al., Elevated serum level of anti-mullerian hormone in patients with polycystic ovary syndrome: Relationship to the ovarian follicle excess and to the follicular arrest, J. Clin. Endocrinol. Metab, vol.88, pp.5957-5962, 2003.

H. Teede, M. Misso, E. C. Tassone, D. Dewailly, E. H. Ng et al., Anti-Mullerian Hormone in PCOS: A Review Informing International Guidelines, Trends Endocrinol. Metab, vol.30, pp.467-478, 2019.

M. Victoria, J. Labrosse, F. Krief, I. Cedrin-durnerin, M. Comtet et al., Anti Mullerian Hormone: More than a biomarker of female reproductive function, J. Gynecol. Obstet. Hum. Reprod, vol.48, pp.19-24, 2019.

A. Pierre, M. Peigne, M. Grynberg, N. Arouche, J. Taieb et al., Loss of LH-induced down-regulation of anti-Mullerian hormone receptor expression may contribute to anovulation in women with polycystic ovary syndrome, Hum. Reprod, vol.28, pp.762-769, 2013.

R. Homburg and G. Crawford, The role of AMH in anovulation associated with PCOS: A hypothesis, Hum. Reprod, vol.29, pp.1117-1121, 2014.

I. Cimino, F. Casoni, X. Liu, A. Messina, J. Parkash et al., Novel role for anti-Mullerian hormone in the regulation of GnRH neuron excitability and hormone secretion, Nat. Commun, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01259206

F. Guerif, R. Bidault, O. Gasnier, M. L. Couet, O. Gervereau et al., Efficacy of blastocyst transfer after implantation failure, Reprod. Biomed. Online, vol.9, pp.630-636, 2004.

J. Vandesompele, K. De-preter, F. Pattyn, B. Poppe, N. Van-roy et al., Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes, Genome Biol, vol.3, 2002.

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