H. Valadi, K. Ekstrom, A. Bossios, M. Sjostrand, J. J. Lee et al., Exosomemediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells, Nat Cell Biol, vol.9, pp.654-663, 2007.

K. Ridder, S. Keller, M. Dams, A. K. Rupp, J. Schlaudraff et al., Extracellular vesicle-mediated transfer of genetic information between the hematopoietic system and the brain in response to inflammation, PLoS Biol, vol.12, p.1001874, 2014.

S. S. Luo, O. Ishibashi, G. Ishikawa, T. Ishikawa, A. Katayama et al., Human villous trophoblasts express and secrete placenta-specific microRNAs into maternal circulation via exosomes, Biol Reprod, vol.81, pp.717-746, 2009.

L. Stevanato, L. Thanabalasundaram, N. Vysokov, and J. D. Sinden, Investigation of content, stoichiometry and transfer of miRNA from human neural stem cell line derived exosomes, PLoS ONE, vol.11, p.146353, 2016.

J. R. Chevillet, Q. Kang, I. K. Ruf, H. A. Briggs, L. N. Vojtech et al., Quantitative and stoichiometric analysis of the microRNA content of exosomes, Proc Natl Acad Sci, vol.111, pp.14888-93, 2014.

Y. He, Y. Ding, B. Liang, J. Lin, T. K. Kim et al., A systematic study of dysregulated MicroRNA in type 2 diabetes mellitus, Int J Mol Sci, vol.18, p.456, 2017.

J. Dooley, J. E. Garcia-perez, J. Sreenivasan, S. M. Schlenner, R. Vangoitsenhoven et al., The microRNA-29 family dictates the balance between homeostatic and pathological glucose handling in diabetes and obesity, Diabetes, vol.65, pp.53-61, 2016.

B. Feng and S. Chakrabarti, miR-320 regulates glucose-induced gene expression in diabetes, ISRN Endocrinol, vol.2012, p.549875, 2012.

M. Latreille, J. Hausser, I. Stutzer, Q. Zhang, B. Hastoy et al., MicroRNA-7a regulates pancreatic beta cell function, J Clin Invest, vol.124, pp.2722-2757, 2014.

D. P. Bartel, MicroRNAs: target recognition and regulatory functions, Cell, vol.136, pp.215-248, 2009.

K. Nakanishi, Anatomy of RISC: how do small RNAs and chaperones activate Argonaute proteins?, Wiley Interdiscip Rev RNA, vol.7, pp.637-60, 2016.

D. J. Gibbings, C. Ciaudo, M. Erhardt, and O. Voinnet, Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity, Nat Cell Biol, vol.11, pp.1143-1152, 2009.
URL : https://hal.archives-ouvertes.fr/hal-00423288

K. Trajkovic, C. Hsu, S. Chiantia, L. Rajendran, D. Wenzel et al., Ceramide triggers budding of exosome vesicles into multivesicular endosomes, Science, vol.319, pp.1244-1251, 2008.

C. Villarroya-beltri, C. Gutierrez-vazquez, F. Sanchez-cabo, D. Perez-hernandez, J. Vazquez et al., Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs, Nat Commun, vol.4, p.2980, 2013.

K. Wang, S. Zhang, J. Weber, D. Baxter, and D. J. Galas, Export of microRNAs and microRNA-protective protein by mammalian cells, Nucleic Acids Res, vol.38, pp.7248-59, 2010.

M. P. Hunter, N. Ismail, X. Zhang, B. D. Aguda, E. J. Lee et al., Detection of microRNA expression in human peripheral blood microvesicles, PLoS ONE, vol.3, p.3694, 2008.

B. Mateescu, E. J. Kowal, B. W. Van-balkom, S. Bartel, S. N. Bhattacharyya et al., Obstacles and opportunities in the functional analysis of extracellular vesicle RNA -an ISEV position paper, J Extracell Vesicles, vol.6, p.1286095, 2017.

J. Kowal, G. Arras, M. Colombo, M. Jouve, J. P. Morath et al., Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes, Proc Natl Acad Sci, vol.113, pp.968-77, 2016.
URL : https://hal.archives-ouvertes.fr/inserm-02450678

Y. Y. Tam, S. Chen, and P. R. Cullis, Advances in lipid nanoparticles for siRNA delivery, Pharmaceutics, vol.5, pp.498-507, 2013.

F. Tabet, K. C. Vickers, C. Torres, L. F. Wiese, C. B. Shoucri et al., HDL-transferred microRNA-223 regulates ICAM-1 expression in endothelial cells, Nat Commun, vol.5, p.3292, 2014.

K. C. Vickers, B. T. Palmisano, B. M. Shoucri, R. D. Shamburek, and A. T. Remaley, MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins, Nat Cell Biol, vol.13, pp.423-456, 2011.

A. Turchinovich, L. Weiz, A. Langheinz, and B. Burwinkel, Characterization of extracellular circulating microRNA, Nucleic Acids Res, vol.39, pp.7223-7256, 2011.

L. Bihan, O. Chevre, R. Mornet, S. Garnier, B. Pitard et al., Probing the in vitro mechanism of action of cationic lipid/DNA lipoplexes at a nanometric scale, Nucleic Acids Res, vol.39, pp.1595-609, 2011.
URL : https://hal.archives-ouvertes.fr/hal-00566862

D. Beuzelin, B. Pitard, and B. Kaeffer, Testing the Transfer of miRNA by Biologically-Inspired Delivery Vehicles on the Physiology of Baby Cells and their Interactions with Gastric Extracellular Vesicles, 2017.

S. Balusu, E. Van-wonterghem, D. Rycke, R. Raemdonck, K. Stremersch et al., Identification of a novel mechanism of bloodbrain communication during peripheral inflammation via choroid plexus-derived extracellular vesicles, EMBO Mol Med, vol.8, pp.1162-83, 2016.

I. Stutzer, D. Esterhazy, and M. Stoffel, The pancreatic beta cell surface proteome, Diabetologia, vol.55, pp.1877-89, 2012.

F. Rubino, Medical research: Time to think differently about diabetes, Nature, vol.533, pp.459-61, 2016.

J. D. Shih and C. P. Hunter, SID-1 is a dsRNA-selective dsRNA-gated channel, RNA, vol.17, pp.1057-65, 2011.

O. P. Wiklander, J. Z. Nordin, A. O'loughlin, Y. Gustafsson, G. Corso et al., Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting, J Extracell Vesicles, vol.4, p.26316, 2015.

W. Heusermann, J. Hean, D. Trojer, E. Steib, S. Von-bueren et al., Exosomes surf on filopodia to enter cells at endocytic hot spots, traffic within endosomes, and are targeted to the ER, J Cell Biol, vol.213, pp.173-84, 2016.

G. Schratt, Fine-tuning neural gene expression with microRNAs, Curr Opin Neurobiol, vol.19, pp.213-222, 2009.

C. Fruhbeis, D. Frohlich, W. P. Kuo, J. Amphornrat, S. Thilemann et al., Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication, PLoS Biol, vol.11, 2013.

Z. F. Li, Y. M. Liang, P. N. Lau, W. Shen, D. K. Wang et al., Dynamic localisation of mature microRNAs in Human nucleoli is influenced by exogenous genetic materials, PLoS ONE, vol.8, p.70869, 2013.

B. C. Melnik, S. M. John, and G. Schmitz, Milk is not just food but most likely a genetic transfection system activating mTORC1 signaling for postnatal growth, Nutr J, vol.12, p.103, 2013.

M. J. Van-herwijnen, M. I. Zonneveld, S. Goerdayal, E. N. Nolte-'t-hoen, J. Garssen et al., Comprehensive proteomic analysis of human milkderived extracellular vesicles unveils a novel functional proteome distinct from other milk components, Mol Cell Proteomics, vol.15, pp.3412-3435, 2016.

Y. Liao, X. Du, J. Li, and B. Lonnerdal, Human milk exosomes and their microRNAs survive digestion in vitro and are taken up by human intestinal cells, Mol Nutr Food Res, vol.61, p.1700082, 2017.

K. Kaur, S. Vig, R. Srivastava, A. Mishra, V. P. Singh et al., Elevated Hepatic miR-22-3p expression impairs gluconeogenesis by silencing the Wnt-responsive transcription factor Tcf7, Diabetes, vol.64, pp.3659-69, 2015.

X. Wang, W. Huang, G. Liu, W. Cai, R. W. Millard et al., Cardiomyocytes mediate anti-angiogenesis in type 2 diabetic rats through the exosomal transfer of miR-320 into endothelial cells, J Mol Cell Cardiol, vol.74, pp.139-50, 2014.

A. Montecalvo, A. T. Larregina, W. J. Shufesky, D. B. Stolz, M. L. Sullivan et al., Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes, Blood, vol.119, pp.756-66, 2012.

F. F. Mo, T. An, Z. J. Zhang, Y. F. Liu, H. X. Liu et al., Jiang Tang Xiao Ke granule play an anti-diabetic role in diabetic mice pancreatic tissue by regulating the mRNAs and MicroRNAs associated with PI3K-Akt signaling pathway, Front Pharmacol, vol.8, p.795, 2017.

D. H. Kim, P. Saetrom, O. Snove, and J. J. Rossi, MicroRNA-directed transcriptional gene silencing in mammalian cells, Proc Natl Acad Sci, vol.105, pp.16230-16235, 2008.

D. Zurawek, M. Kusmider, A. Faron-gorecka, P. Gruca, P. Pabian et al., Reciprocal MicroRNA expression in mesocortical circuit and its interplay with serotonin transporter define resilient rats in the chronic mild stress, Mol Neurobiol, vol.54, pp.5741-51, 2017.

H. W. Hwang, E. A. Wentzel, and J. T. Mendell, A hexanucleotide element directs microRNA nuclear import, Science, vol.315, pp.97-100, 2007.

H. F. Xia, X. H. Jin, P. P. Song, Y. Cui, C. M. Liu et al., Temporal and spatial regulation of miR-320 in the uterus during embryo implantation in the rat, Int J Mol Sci, vol.11, pp.719-749, 2010.

X. P. Ren, J. Wu, X. Wang, M. A. Sartor, K. Jones et al., MicroRNA-320 is involved in the regulation of cardiac ischemia/reperfusion injury by targeting heat-shock protein 20, Circulation, vol.119, pp.2357-66, 2009.

C. V. Collares, A. F. Evangelista, D. J. Xavier, D. M. Rassi, T. Arns et al., Identifying common and specific microRNAs expressed in peripheral blood mononuclear cell of type 1, type 2, and gestational diabetes mellitus patients, BMC Res Notes, vol.6, p.491, 2013.
URL : https://hal.archives-ouvertes.fr/hal-01595814

Q. Zhou, M. Li, X. Wang, Q. Li, T. Wang et al., Immune-related MicroRNAs are abundant in breast milk exosomes, Int J Biol Sci, vol.8, pp.118-141, 2012.

C. Lasser, V. S. Alikhani, K. Ekstrom, M. Eldh, P. T. Paredes et al., Human saliva, plasma and breast milk exosomes contain RNA: uptake by macrophages, J Transl Med, vol.9, p.9, 2011.

B. Kaeffer, H. Billard, C. Y. Boquien, E. Gauvard, A. Drouard et al., Early nutrition: transcriptomic profiling of exfoliated cells, microvesicles and exosomes from breast milk and corresponding gastric fluid aspirate of preterm infant, J Dev Orig Health Dis, vol.6, 2015.

M. Inventors-mayr, Methods and Means for Predicting or Diagnosing Diabetes or Cardiovascular Disorders Based on Micro RNA Detection. King's College London patent WO, p.1, 2011.

W. J. Huang, M. Li, X. H. Jin, X. J. Huang, W. Zhao et al., Genetic profile and biological implication of PIN2/TRF1-interacting telomerase inhibitor 1 (PinX1) in human cancers: an analysis using The Cancer Genome Atlas, Oncotarget, vol.8, pp.67241-53, 2017.

M. M. Ittmann, Cell cycle control of the BN51 cell cycle gene which encodes a subunit of RNA polymerase III, Cell Growth Differ, vol.5, pp.783-791, 1994.

L. Pigati, S. C. Yaddanapudi, R. Iyengar, D. J. Kim, S. A. Hearn et al., Selective release of microRNA species from normal and malignant mammary epithelial cells, PLoS ONE, vol.5, p.13515, 2010.

M. Trajkovski, J. Hausser, J. Soutschek, B. Bhat, A. Akin et al., MicroRNAs 103 and 107 regulate insulin sensitivity, Nature, vol.474, pp.649-53, 2011.

D. S. Sutaria, J. Jiang, O. A. Elgamal, S. M. Pomeroy, M. Badawi et al., Low active loading of cargo into engineered extracellular vesicles results in inefficient miRNA mimic delivery, J Extracell Vesicles, vol.6, p.1333882, 2017.

J. Zangari, M. Ilie, F. Rouaud, L. Signetti, M. Ohanna et al., Rapid decay of engulfed extracellular miRNA by XRN1 exonuclease promotes transient epithelial-mesenchymal transition, Nucleic Acids Res, vol.45, pp.4131-4172, 2017.
URL : https://hal.archives-ouvertes.fr/hal-02526314

D. Jeong, J. W. Yoon, J. Kim, J. Gianchandani, S. Gho et al., Nanovesicles engineered from ES cells for enhanced cell proliferation, Biomaterials, vol.35, pp.9302-9312, 2014.

P. Zhang, L. Zhang, Z. Qin, S. Hua, Z. Guo et al., Genetically engineered liposome-like nanovesicles as active targeted transport platform, Adv Mater, vol.30, p.1705350, 2018.

R. Munagala, F. Aqil, J. Jeyabalan, and R. C. Gupta, Bovine milk-derived exosomes for drug delivery, Cancer Lett, vol.371, pp.48-61, 2016.

S. R. Baier, C. Nguyen, F. Xie, J. R. Wood, and J. Zempleni, MicroRNAs are absorbed in biologically meaningful amounts from nutritionally relevant doses of cow milk and affect gene expression in peripheral blood mononuclear cells, HEK-293 kidney cell cultures, and mouse livers, J Nutr, vol.144, pp.1495-500, 2014.

J. Ma, C. Wang, K. Long, H. Zhang, J. Zhang et al., Exosomal microRNAs in giant panda (Ailuropoda melanoleuca) breast milk: potential maternal regulators for the development of newborn cubs, vol.7, p.3507, 2017.

M. I. Zonneveld, A. R. Brisson, M. Van-herwijnen, S. Tan, C. Van-de-lest et al., Recovery of extracellular vesicles from human breast milk is influenced by sample collection and vesicle isolation procedures, J Extracell Vesicles, vol.3, p.24215, 2014.

W. F. Lima, T. P. Prakash, H. M. Murray, G. A. Kinberger, W. Li et al., Single-stranded siRNAs activate RNAi in animals, Cell, vol.150, pp.883-94, 2012.

G. Mullokandov, A. Baccarini, A. Ruzo, A. D. Jayaprakash, N. Tung et al., High-throughput assessment of microRNA activity and function using microRNA sensor and decoy libraries, Nat Methods, vol.9, pp.840-846, 2012.

P. Garcia-manrique, G. Gutierrez, and M. C. Blanco-lopez, Fully artificial exosomes: towards new theranostic biomaterials, Trends Biotechnol, vol.36, pp.10-14, 2018.

S. C. Jang, O. Y. Kim, C. M. Yoon, D. S. Choi, T. Y. Roh et al., Bioinspired exosome-mimetic nanovesicles for targeted delivery of chemotherapeutics to malignant tumors, ACS Nano, vol.7, pp.7698-710, 2013.

H. De-la-pena, J. A. Madrigal, S. Rusakiewicz, M. Bencsik, G. W. Cave et al., Artificial exosomes as tools for basic and clinical immunology, J Immunol Methods, vol.344, pp.121-153, 2009.

L. Martinez-lostao, F. Garcia-alvarez, G. Basanez, E. Alegre-aguaron, P. Desportes et al., Liposome-bound APO2L/TRAIL is an effective treatment in a rabbit model of rheumatoid arthritis, Arthritis Rheum, vol.62, pp.2272-82, 2010.

S. Viaud, S. Ploix, V. Lapierre, C. Thery, P. H. Commere et al., Updated technology to produce highly immunogenic dendritic cell-derived exosomes of clinical grade: a critical role of interferon-gamma, J Immunother, vol.34, pp.65-75, 2011.

D. De-miguel, G. Basanez, D. Sanchez, P. G. Malo, I. Marzo et al., Liposomes decorated with Apo2L/TRAIL overcome chemoresistance of human hematologic tumor cells, Mol Pharm, vol.10, pp.893-904, 2013.

W. Jo, D. Jeong, J. Kim, S. Cho, S. C. Jang et al., Microfluidic fabrication of cell-derived nanovesicles as endogenous RNA carriers, Lab Chip, vol.14, pp.1261-1270, 2014.

J. Yoon, J. W. Jeong, D. Kim, J. Jeong, H. Park et al., Generation of nanovesicles with sliced cellular membrane fragments for exogenous material delivery, Biomaterials, vol.59, pp.12-20, 2015.

K. Li, S. Chang, Z. Wang, X. Zhao, and D. Chen, A novel micro-emulsion and micelle assembling method to prepare DEC205 monoclonal antibody coupled cationic nanoliposomes for simulating exosomes to target dendritic cells, Int J Pharm, vol.491, pp.105-117, 2015.

T. Colombani, P. Peuziat, L. Dallet, T. Haudebourg, M. Mevel et al., Self-assembling complexes between binary mixtures of lipids with different linkers and nucleic acids promote universal mRNA, DNA and siRNA delivery, J Control Release, vol.249, pp.131-173, 2017.
URL : https://hal.archives-ouvertes.fr/inserm-01473687

D. Habrant, P. Peuziat, T. Colombani, L. Dallet, J. Gehin et al., Design of ionizable lipids to overcome the limiting step of endosomal escape: application in the intracellular delivery of mRNA, DNA, and siRNA, J Med Chem, vol.59, pp.3046-62, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01831743

E. W. Harville, S. Srinivasan, W. Chen, and G. S. Berenson, Is the metabolic syndrome a "small baby" syndrome?: the bogalusa heart study, Metab Syndr Relat Disord, vol.10, pp.413-434, 2012.

S. Ip, M. Chung, G. Raman, P. Chew, N. Magula et al., Breastfeeding and maternal and infant health outcomes in developed countries, Evid Rep Technol Assess (Full Rep), pp.1-186, 2007.

S. Fais, L. O'driscoll, F. E. Borras, E. Buzas, G. Camussi et al., Evidence-Based Clinical Use of Nanoscale Extracellular Vesicles in Nanomedicine, ACS Nano, vol.10, pp.3886-99, 2016.
URL : https://hal.archives-ouvertes.fr/hal-02640550