Enterotypes in the landscape of gut microbial community composition
Paul I Costea
(1)
,
Falk Hildebrand
(2, 3, 1)
,
Arumugam Manimozhiyan
(4)
,
Fredrik Bäckhed
(5, 6)
,
Martin J. Blaser
(7)
,
Frederic D. Bushman
(8)
,
Willem de Vos
(9, 10)
,
Dusko S Ehrlich
(11, 12)
,
Claire M. Fraser
(13)
,
Masahira Hattori
(14)
,
Curtis Huttenhower
(15)
,
Ian B. Jeffery
(16)
,
Dan Knights
(17, 18)
,
James D. Lewis
(8)
,
Ruth E. Ley
(19)
,
Howard Ochman
(20)
,
Paul O'Toole
(16)
,
Christopher Quince
(21)
,
David Relman A
(22, 23)
,
Fergus Shanahan
(16)
,
Shinichi Sunagawa
(24, 1)
,
Junun Wang
(6, 25, 26, 27, 28)
,
George Matthew Weinstock
(29)
,
Gary D. Wu
(8)
,
Georg Zeller
(1)
,
Liping Zhao
(30)
,
Jeroen Raes
(2, 3, 31)
,
Rob Knight
(32, 33, 34, 35)
,
Peer Bork
(1, 36, 37)
1
EMBL -
European Molecular Biology Laboratory
2 VUB - Vrije Universiteit Brussel
3 Flanders Institute for Biotechnology
4 CBMR - Novo Nordisk Foundation Center for Basic Metabolic Research
5 UCPH - University of Copenhagen = Københavns Universitet
6 GU - Göteborgs Universitet = University of Gothenburg
7 NYU Langone Medical Center - New York University Langone Medical Center
8 University of Pennyslvania
9 Helsingin yliopisto = Helsingfors universitet = University of Helsinki
10 Laboratory of Microbiology
11 MetaGenoPolis
12 Centre for Host-Microbiome Interactions, Dental Institute Central Office, Guy’s Hospital
13 University of Maryland School of Medicine
14 Waseda University [Tokyo, Japan]
15 Harvard School of Public Health
16 APC Microbiome Institute [Cork]
17 UMN - University of Minnesota [Twin Cities]
18 Department of Computer Science and Engineering
19 Max Planck Institute for Developmental Biology
20 IB - Department of Integrative Biology [Berkeley]
21 Warwick Medical School
22 Stanford University
23 Veterans Affairs Palo Alto Health Care System
24 ETH Zürich - Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich]
25 Department of Biology
26 Princess Al Jawhara Albrahim Center of Excellence in the Research of Hereditary Disorders
27 MUST - Macau University of Science and Technology
28 Department of Medicine and State Key Laboratory of Pharmaceutical Biotechnology
29 JAX - The Jackson Laboratory [Bar Harbor]
30 Shanghai Jiao Tong University School of Medicine
31 UCL - Université Catholique de Louvain = Catholic University of Louvain
32 University of Colorado
33 University of Colorado [Boulder]
34 Department of Chemistry and Biochemistry [Boulder]
35 University of Colorado Anschutz [Aurora]
36 Molecular Medicine Partnership Unit
37 MDC - Max Delbrück Center for Molecular Medicine [Berlin]
2 VUB - Vrije Universiteit Brussel
3 Flanders Institute for Biotechnology
4 CBMR - Novo Nordisk Foundation Center for Basic Metabolic Research
5 UCPH - University of Copenhagen = Københavns Universitet
6 GU - Göteborgs Universitet = University of Gothenburg
7 NYU Langone Medical Center - New York University Langone Medical Center
8 University of Pennyslvania
9 Helsingin yliopisto = Helsingfors universitet = University of Helsinki
10 Laboratory of Microbiology
11 MetaGenoPolis
12 Centre for Host-Microbiome Interactions, Dental Institute Central Office, Guy’s Hospital
13 University of Maryland School of Medicine
14 Waseda University [Tokyo, Japan]
15 Harvard School of Public Health
16 APC Microbiome Institute [Cork]
17 UMN - University of Minnesota [Twin Cities]
18 Department of Computer Science and Engineering
19 Max Planck Institute for Developmental Biology
20 IB - Department of Integrative Biology [Berkeley]
21 Warwick Medical School
22 Stanford University
23 Veterans Affairs Palo Alto Health Care System
24 ETH Zürich - Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich]
25 Department of Biology
26 Princess Al Jawhara Albrahim Center of Excellence in the Research of Hereditary Disorders
27 MUST - Macau University of Science and Technology
28 Department of Medicine and State Key Laboratory of Pharmaceutical Biotechnology
29 JAX - The Jackson Laboratory [Bar Harbor]
30 Shanghai Jiao Tong University School of Medicine
31 UCL - Université Catholique de Louvain = Catholic University of Louvain
32 University of Colorado
33 University of Colorado [Boulder]
34 Department of Chemistry and Biochemistry [Boulder]
35 University of Colorado Anschutz [Aurora]
36 Molecular Medicine Partnership Unit
37 MDC - Max Delbrück Center for Molecular Medicine [Berlin]
Dusko S Ehrlich
- Fonction : Auteur
- PersonId : 1203280
Christopher Quince
- Fonction : Auteur
- PersonId : 776169
- ORCID : 0000-0003-1884-8440
Junun Wang
- Fonction : Auteur
Jeroen Raes
- Fonction : Auteur correspondant
Rob Knight
- Fonction : Auteur correspondant
- PersonId : 762535
- ORCID : 0000-0002-0975-9019
- IdRef : 192695541
Peer Bork
- Fonction : Auteur correspondant
Résumé
Population stratification is a useful approach for a better understanding of complex biological problems in human health and wellbeing. The proposal that such stratification applies to the human gut microbiome, in the form of distinct community composition types termed enterotypes, has been met with both excitement and controversy. In view of accumulated data and re-analyses since the original work, we revisit the concept of enterotypes, discuss different methods of dividing up the landscape of possible microbiome configurations, and put these concepts into functional, ecological and medical contexts. As enterotypes are of use in describing the gut microbial community landscape and may become relevant in clinical practice, we aim to reconcile differing views and encourage a balanced application of the concept.