Eaaci position paper: Influence of dietary fatty acids on asthma, food allergy, and atopic dermatitis
Carina Venter
(1)
,
Rosan W. Meyer
(2)
,
Bright I. Nwaru
(3)
,
Caroline Roduit
(4)
,
Eva Untersmayr
(5)
,
Karine Adel-Patient
(6, 7)
,
Ioana Agache
(8)
,
Carlo Agostoni
(9, 10)
,
Cezmi A. Akdis
(11, 12)
,
Stephan Bischoff
(13)
,
George Du Toit
(14, 15)
,
Mary Feeney
(14, 15)
,
Remo Frei
(11, 12)
,
Holger Garn
(16)
,
Matthew Greenhawt
(17)
,
Karin Hoffmann‐sommergruber
(5)
,
Nonhlanhla Lunjani
(12, 18)
,
Kate Maslin
(19)
,
Clare Mills
(20)
,
Antonella Muraro
(21)
,
Isabella Pali
(5)
,
Lars Poulson
(22)
,
Imke Reese
(23)
,
Harald Renz
(24)
,
Graham C. Roberts
(25, 26, 27)
,
Peter Smith
(28)
,
Sylwia Smolinska
(29)
,
Milena Sokolowska
(12)
,
Catherine Stanton
(30)
,
Berber Vlieg‐boerstra
(31)
1
University of Colorado
2 Imperial College London
3 GU - Göteborgs Universitet = University of Gothenburg
4 University Children’s Hospital Zurich
5 Medizinische Universität Wien = Medical University of Vienna
6 SPI - Service de Pharmacologie et Immunoanalyse
7 Université Paris Saclay (COmUE)
8 Sapientia Hungarian University of Transylvania
9 Ospedale Maggiore Policlinico
10 UNIMI - Università degli Studi di Milano = University of Milan
11 Christine Kühne Center
12 SIAF - Swiss Institute of Allergy and Asthma Research
13 University of Hohenheim
14 King‘s College London
15 Guy's and St Thomas' Hospitals
16 Philipps Universität Marburg = Philipps University of Marburg
17 University of Colorado Anschutz [Aurora]
18 University of Cape Town
19 MRC Lifecourse Epidemiology Unit
20 School of Biological Sciences, Manchester Academic Health Sciences Centre, Manchester Institute of Biotechnology
21 Unipd - Università degli Studi di Padova = University of Padua
22 Copenhagen University Hospitals
23 Dietary Counseling and Nutrition Therapy Centre
24 Institute of Laboratory Medicine
25 The David Hide Asthma and Allergy Research Centre
26 NIHR Biomedical Research Centre
27 University of Southampton
28 Griffith University [Brisbane]
29 Department of Clinical Immunology
30 APC Microbiome Ireland
31 OLVG
2 Imperial College London
3 GU - Göteborgs Universitet = University of Gothenburg
4 University Children’s Hospital Zurich
5 Medizinische Universität Wien = Medical University of Vienna
6 SPI - Service de Pharmacologie et Immunoanalyse
7 Université Paris Saclay (COmUE)
8 Sapientia Hungarian University of Transylvania
9 Ospedale Maggiore Policlinico
10 UNIMI - Università degli Studi di Milano = University of Milan
11 Christine Kühne Center
12 SIAF - Swiss Institute of Allergy and Asthma Research
13 University of Hohenheim
14 King‘s College London
15 Guy's and St Thomas' Hospitals
16 Philipps Universität Marburg = Philipps University of Marburg
17 University of Colorado Anschutz [Aurora]
18 University of Cape Town
19 MRC Lifecourse Epidemiology Unit
20 School of Biological Sciences, Manchester Academic Health Sciences Centre, Manchester Institute of Biotechnology
21 Unipd - Università degli Studi di Padova = University of Padua
22 Copenhagen University Hospitals
23 Dietary Counseling and Nutrition Therapy Centre
24 Institute of Laboratory Medicine
25 The David Hide Asthma and Allergy Research Centre
26 NIHR Biomedical Research Centre
27 University of Southampton
28 Griffith University [Brisbane]
29 Department of Clinical Immunology
30 APC Microbiome Ireland
31 OLVG
Eva Untersmayr
- Fonction : Auteur
- PersonId : 795378
- ORCID : 0000-0002-1963-499X
Karine Adel-Patient
- Fonction : Auteur
- PersonId : 1198855
- IdHAL : karine-adel-patient
- ORCID : 0000-0002-2242-0626
Ioana Agache
- Fonction : Auteur
- PersonId : 767614
- ORCID : 0000-0001-7994-364X
Antonella Muraro
- Fonction : Auteur
- PersonId : 767935
- ORCID : 0000-0002-5026-5862
Peter Smith
- Fonction : Auteur
- PersonId : 762539
- ORCID : 0000-0002-3801-3064
Milena Sokolowska
- Fonction : Auteur
- PersonId : 800932
- ORCID : 0000-0001-9710-6685
Résumé
The prevalence of allergic diseases such as allergic rhinitis, asthma, food allergy, and atopic dermatitis has increased dramatically during the last decades, which is associated with altered environmental exposures and lifestyle practices. The purpose of this review was to highlight the potential role for dietary fatty acids, in the prevention and management of these disorders. In addition to their nutritive value, fatty acids have important immunoregulatory effects. Fatty acid-associated biological mechanisms, human epidemiology, and intervention studies are summarized in this review. The influence of genetics and the microbiome on fatty acid metabolism is also discussed. Despite critical gaps in our current knowledge, it is increasingly apparent that dietary intake of fatty acids may influence the development of inflammatory and tolerogenic immune responses. However, the lack of standardized formats (ie, food versus supplement) and standardized doses, and frequently a lack of prestudy serum fatty acid level assessments in clinical studies significantly limit our ability to compare allergy outcomes across studies and to provide clear recommendations at this time. Future studies must address these limitations and individualized medical approaches should consider the inclusion of specific dietary factors for the prevention and management of asthma, food allergy, and atopic dermatitis.