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Structure and antimicrobial activity of platypus ‘intermediate’ defensin-like peptide

Abstract : he three-dimensional structure of a chemically synthesized peptide that we have called ` intermediate' defensin-like peptide (Int-DLP), from the platypus genome, was determined by nuclear magnetic resonance (NMR) spectroscopy; and its antimicrobial activity was investigated. The overall structural fold of Int-DLP was similar to that of the DLPs and beta-defensins, however the presence of a third antiparallel beta-strand makes its structure more similar to the beta-defensins than the DLPs. Int-DLP displayed potent antimicrobial activity against Staphylococcus aureus and Pseudomonas aeruginosa. The four arginine residues at the N-terminus of Int-DLP did not affect the overall fold, but were important for its antimicrobial potency.
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Allan Torres, Paramjit Bansal, Jennifer Koh, Guilhem Pages, Wu Ming, et al.. Structure and antimicrobial activity of platypus ‘intermediate’ defensin-like peptide. FEBS Letters, Wiley, 2014, 588 (9), pp.1821-1826. ⟨10.1016/j.febslet.2014.03.044⟩. ⟨hal-02632080⟩



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