Genomic insights into the Ixodes scapularis tick vector of Lyme disease
Monika Gulia-Nuss
(1, 2)
,
Andrew B. Nuss
(1, 2)
,
Jason M. Meyer
(3, 2)
,
Daniel E. Sonenshine
(4)
,
R. Michael Roe
(5)
,
Robert M. Waterhouse
(6, 7, 8, 9)
,
David B. Sattelle
(10)
,
Jose de La Fuente
(11, 12)
,
Jose M. Ribeiro
(13)
,
Karine Megy
(14, 15)
,
Jyothi Thimmapuram
(16)
,
Jason R. Miller
(17)
,
Brian P. Walenz
(17)
,
Sergey Koren
(17)
,
Jessica B. Hostetler
(17)
,
Mathangi Thiagarajan
(17)
,
Vinita S. Joardar
(17)
,
Linda I. Hannick
(17)
,
Shelby Bidwell
(17)
,
Martin P. Hammond
(15)
,
Sarah Young
(7)
,
Qiandong Zeng
(7)
,
Jenica L. Abrudan
(18)
,
Francisca C. Almeida
(19)
,
Nieves Ayllon
(11)
,
Ketaki Bhide
(16)
,
Brooke W. Bissinger
(5)
,
Elena Bonzon-Kulichenko
(20)
,
Steven D. Buckingham
(10)
,
Daniel R. Caffrey
(21)
,
Melissa J. Caimano
(22)
,
Vincent Croset
(23)
,
Timothy Driscoll
(24)
,
Don Gilbert
(25)
,
Joseph J. Gillespie
(24)
,
Gloria I. Giraldo-Calderon
(18, 2)
,
Jeffrey M. Grabowski
(2, 16)
,
David Jiang
(26)
,
Sayed M. S. Khalil
(27)
,
Donghun Kim
(28)
,
Katherine M. Kocan
(12)
,
Juraj Koči
(2)
,
Richard J. Kuhn
(16)
,
Timothy J. Kurtti
(29)
,
Kristin Lees
(30)
,
Emma G. Lang
(2)
,
Ryan C. Kennedy
(31)
,
Hyeogsun Kwon
(28)
,
Rushika Perera
(16)
,
Yumin Qi
(26)
,
Justin D. Radolf
(22)
,
Joyce M. Sakamoto
(32)
,
Alejandro Sanchez-Gracia
(19)
,
Maiara S. Severo
(33)
,
Neal Silverman
(21)
,
Marta Tojo
(34, 14)
,
Cristian Tornador
(35)
,
Janice P. van Zee
(2)
,
Jesus Vazquez
(20)
,
Filipe G. Vieira
(36)
,
Margarita Villar
(11)
,
Adam R. Wespiser
(21)
,
Yunlong Yang
(28)
,
Jiwei Zhu
(5)
,
Peter Arensburger
(37)
,
Patricia V. Pietrantonio
(28)
,
Stephen C. Barker
(38)
,
Renfu Shao
(39)
,
Evgeny M. Zdobnov
(6, 8)
,
Frank Hauser
(40)
,
Cornelis J. P. Grimmelikhuijzen
(40)
,
Yoonseong Park
(2)
,
Julio Rozas
(36)
,
Richard Benton
(23)
,
Joao H. F. Pedra
(33)
,
David R. Nelson
(41)
,
Maria F. Unger
(18)
,
Jose M. C. Tubio
(42, 43)
,
Zhijian Tu
(26)
,
Hugh M. Robertson
(44)
,
Martin Shumway
(17)
,
Granger Sutton
(17)
,
Jennifer R. Wortman
(17)
,
Daniel Lawson
(15)
,
Stephen K. Wikel
(45)
,
Vishvanath M. Nene
(17)
,
Claire M. Fraser
,
Frank H. Collins
,
Bruce Birren
,
Karen E. Nelson
(17)
,
Elisabet Caler
(17)
,
Catherine A. Hill
(2)
1
University of Nevada
2 Department of Entomology
3 Department Biotechnology
4 Department of Biological Sciences
5 NC State - North Carolina State University [Raleigh]
6 Department of Genetic Medicine and Development
7 Broad Institute of Harvard and MIT
8 SIB - Swiss Institute of Bioinformatics [Lausanne]
9 MIT - Massachusetts Institute of Technology
10 UCL - University College of London [London]
11 SaBio
12 Department of Veterinary Pathobiology, Center for Veterinary Health Sciences
13 NIAID - National Institute of Allergy and Infectious Deseases
14 CAM - University of Cambridge [UK]
15 VectorBase
16 Purdue University [West Lafayette]
17 JCVI - J. Craig Venter Institute [La Jolla, USA]
18 Department of Biological Sciences
19 UAB - Universitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona
20 CNIC - Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III
21 UMASS - University of Massachusetts Medical School [Worcester]
22 UCONN - University of Connecticut
23 UNIL - Université de Lausanne = University of Lausanne
24 Virginia Polytechnic Institute and State University [Blacksburg]
25 Department of Biology
26 Department of Biochemistry [Blacksburg]
27 Agricultural Research Center
28 Department of Entomology
29 Minnesota State University
30 University of Manchester [Manchester]
31 Department of Bioengineering and Therapeutic Sciences
32 Department of Entomology
33 UC Riverside - University of California [Riverside]
34 USC - Universidade de Santiago de Compostela [Spain]
35 Department of Experimental and Health Sciences
36 University of Barcelona
37 CAL POLY POMONA - California State Polytechnic University [Pomona]
38 UQ [All campuses : Brisbane, Dutton Park Gatton, Herston, St Lucia and other locations] - The University of Queensland
39 USC - University of the Sunshine Coast
40 UCPH - University of Copenhagen = Københavns Universitet
41 University of Tennessee
42 Universidade de Vigo
43 Cancer Genome Project
44 University of Illinois
45 Quinnipiac University
2 Department of Entomology
3 Department Biotechnology
4 Department of Biological Sciences
5 NC State - North Carolina State University [Raleigh]
6 Department of Genetic Medicine and Development
7 Broad Institute of Harvard and MIT
8 SIB - Swiss Institute of Bioinformatics [Lausanne]
9 MIT - Massachusetts Institute of Technology
10 UCL - University College of London [London]
11 SaBio
12 Department of Veterinary Pathobiology, Center for Veterinary Health Sciences
13 NIAID - National Institute of Allergy and Infectious Deseases
14 CAM - University of Cambridge [UK]
15 VectorBase
16 Purdue University [West Lafayette]
17 JCVI - J. Craig Venter Institute [La Jolla, USA]
18 Department of Biological Sciences
19 UAB - Universitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona
20 CNIC - Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III
21 UMASS - University of Massachusetts Medical School [Worcester]
22 UCONN - University of Connecticut
23 UNIL - Université de Lausanne = University of Lausanne
24 Virginia Polytechnic Institute and State University [Blacksburg]
25 Department of Biology
26 Department of Biochemistry [Blacksburg]
27 Agricultural Research Center
28 Department of Entomology
29 Minnesota State University
30 University of Manchester [Manchester]
31 Department of Bioengineering and Therapeutic Sciences
32 Department of Entomology
33 UC Riverside - University of California [Riverside]
34 USC - Universidade de Santiago de Compostela [Spain]
35 Department of Experimental and Health Sciences
36 University of Barcelona
37 CAL POLY POMONA - California State Polytechnic University [Pomona]
38 UQ [All campuses : Brisbane, Dutton Park Gatton, Herston, St Lucia and other locations] - The University of Queensland
39 USC - University of the Sunshine Coast
40 UCPH - University of Copenhagen = Københavns Universitet
41 University of Tennessee
42 Universidade de Vigo
43 Cancer Genome Project
44 University of Illinois
45 Quinnipiac University
Sarah Young
- Fonction : Auteur
- PersonId : 763962
- ORCID : 0000-0003-3862-3863
Claire M. Fraser
- Fonction : Auteur
Frank H. Collins
- Fonction : Auteur
Bruce Birren
- Fonction : Auteur
Résumé
Ticks transmit more pathogens to humans and animals than any other arthropod. We describe the 2.1 Gbp nuclear genome of the tick, Ixodes scapularis (Say), which vectors pathogens that cause Lyme disease, human granulocytic anaplasmosis, babesiosis and other diseases. The large genome reflects accumulation of repetitive DNA, new lineages of retro-transposons, and gene architecture patterns resembling ancient metazoans rather than pancrustaceans. Annotation of scaffolds representing similar to 57% of the genome, reveals 20,486 protein-coding genes and expansions of gene families associated with tick-host interactions. We report insights from genome analyses into parasitic processes unique to ticks, including host 'questing', prolonged feeding, cuticle synthesis, blood meal concentration, novel methods of haemoglobin digestion, haem detoxification, vitellogenesis and prolonged off-host survival. We identify proteins associated with the agent of human granulocytic anaplasmosis, an emerging disease, and the encephalitis-causing Langat virus, and a population structure correlated to life-history traits and transmission of the Lyme disease agent.
Origine : Fichiers éditeurs autorisés sur une archive ouverte
