L. Beutin, Emerging enterohaemorrhagic Escherichia coli, causes and effects of the rise of a human pathogen, J. Vet. Med. B Infect. Dis. Vet. Public Health, vol.53, pp.299-305, 2006.

M. Bielaszewska, A. Mellmann, W. Zhang, R. Kock, A. Fruth et al., Characterisation of the Escherichia coli strain associated with an outbreak of haemolytic uraemic syndrome in Germany, 2011: a microbiological study, Lancet Infect. Dis, vol.11, pp.671-676, 2011.

M. C. Cergole-novella, L. S. Nishimura, L. F. Santos, K. Irino, T. M. Vaz et al., Distribution of virulence profiles related to new toxins and putative adhesins in Shiga toxin-producing Escherichia coli isolated from diverse sources in Brazil, FEMS Microbiol. Lett, vol.274, pp.329-334, 2007.

B. Chassaing, L. Etienne-mesmin, R. Bonnet, and A. Darfeuille-michaud, Bile salts induce long polar fimbriae expression favouring Crohn's diseaseassociated adherent-invasive Escherichia coli interaction with Peyer's patches, Environ. Microbiol, vol.15, pp.355-371, 2013.

Y. Chong, R. Fitzhenry, R. Heuschkel, F. Torrente, G. Frankel et al., Human intestinal tissue tropism in Escherichia coli O157: H7-initial colonization of terminal ileum and Peyer's patches and minimal colonic adhesion ex vivo, Microbiology, vol.153, pp.794-802, 2007.

A. Clements, J. C. Young, N. Constantinou, and G. Frankel, Infection strategies of enteric pathogenic Escherichia coli, Gut Microbes, vol.3, pp.71-87, 2012.

S. Doughty, J. Sloan, V. Bennett-wood, M. Robertson, R. M. Robins-browne et al., Identification of a novel fimbrial gene cluster related to long polar fimbriae in locus of enterocyte effacement-negative strains of enterohemorrhagic Escherichia coli, Infect. Immun, vol.70, pp.6761-6769, 2002.

L. Etienne-mesmin, B. Chassaing, P. Sauvanet, J. Denizot, S. Blanquet-diot et al., Interactions with M cells and macrophages as key steps in the pathogenesis of enterohemorrhagic Escherichia coli infections, PLoS ONE, vol.6, p.23594, 2011.
URL : https://hal.archives-ouvertes.fr/hal-00748909

L. Etienne-mesmin, V. Livrelli, M. Privat, S. Denis, J. M. Cardot et al., Effect of a new probiotic Saccharomyces cerevisiae strain on survival of Escherichia coli O157:H7 in a dynamic gastrointestinal model, Appl. Environ. Microbiol, vol.77, pp.1127-1131, 2011.
URL : https://hal.archives-ouvertes.fr/hal-02651064

R. Fitzhenry, S. Dahan, A. G. Torres, Y. Chong, R. Heuschkel et al., Long polar fimbriae and tissue tropism in Escherichia coli O157:H7. Microbes Infect, vol.8, pp.1741-1749, 2006.

R. J. Fitzhenry, D. J. Pickard, E. L. Hartland, S. Reece, G. Dougan et al., Intimin type influences the site of human intestinal mucosal colonisation by enterohaemorrhagic Escherichia coli O157:H7, Gut, vol.50, pp.180-185, 2002.

C. Frank, D. Werber, J. P. Cramer, M. Askar, M. Faber et al., Epidemic profile of Shiga-toxin-producing Escherichia coli O104:H4 outbreak in Germany, N. Engl. J. Med, vol.365, pp.1771-1780, 2011.

J. P. Girardeau, A. Dalmasso, Y. Bertin, C. Ducrot, S. Bord et al., Association of virulence genotype with phylogenetic background in comparison to different seropathotypes of Shiga toxin-producing Escherichia coli isolates, J. Clin. Microbiol, vol.43, pp.6098-6107, 2005.

L. Golan, E. Gonen, S. Yagel, I. Rosenshine, and N. Y. Shpigel, Enterohemorrhagic Escherichia coli induce attaching and effacing lesions and hemorrhagic colitis in human and bovine intestinal xenograft models, Dis. Model. Mech, vol.4, pp.86-94, 2011.

R. D. Hayward, J. M. Leong, V. Koronakis, and K. G. Campellone, Exploiting pathogenic Escherichia coli to model transmembrane receptor signalling, Nat. Rev. Micro, vol.4, pp.358-370, 2006.

T. D. Ho, B. M. Davis, J. M. Ritchie, and M. K. Waldor, Type 2 secretion promotes enterohemorrhagic Escherichia coli adherence and intestinal colonization, Infect. Immun, vol.76, pp.1858-1865, 2008.

H. S. Hussein, Prevalence and pathogenicity of Shiga toxin-producing Escherichia coli in beef cattle and their products, J. Anim. Sci, vol.85, pp.63-72, 2007.

M. A. Karmali, M. Mascarenhas, S. Shen, K. Ziebell, S. Johnson et al., Association of genomic O island 122 of Escherichia coli EDL 933 with verocytotoxin-producing Escherichia coli seropathotypes that are linked to epidemic and/or serious disease, J. Clin. Microbiol, vol.41, pp.4930-4940, 2003.

S. Knutton, T. Baldwin, P. H. Williams, and A. S. Mcneish, Actin accumulation at sites of bacterial adhesion to tissue culture cells: basis of a new diagnostic test for enteropathogenic and enterohemorrhagic Escherichia coli, Infect. Immun, vol.57, pp.1290-1298, 1989.

Z. Li, E. Elliott, J. Payne, J. Isaacs, P. Gunning et al., Shiga toxin-producing Escherichia coli can impair T84 cell structure and function without inducing attaching/effacing lesions, Infect. Immun, vol.67, pp.5938-5945, 1999.

A. Mahajan, C. G. Currie, S. Mackie, J. Tree, S. Mcateer et al., An investigation of the expression and adhesin function of H7 flagella in the interaction of Escherichia coli O157: H7 with bovine intestinal epithelium, Cell. Microbiol, vol.11, pp.121-137, 2009.

E. M. Mallick, M. E. Mcbee, V. K. Vanguri, A. R. Melton-celsa, K. Schlieper et al., A novel murine infection model for Shiga toxinproducing Escherichia coli, J. Clin. Invest, vol.122, pp.4012-4024, 2012.

M. L. Mckee and A. D. Brien, Investigation of enterohemorrhagic Escherichia coli O157:H7 adherence characteristics and invasion potential reveals a new attachment pattern shared by intestinal E. coli, Infect. Immun, vol.63, pp.2070-2074, 1995.

R. Mundy, S. Schuller, F. Girard, J. M. Fairbrother, A. D. Phillips et al., Functional studies of intimin in vivo and ex vivo: implications for host specificity and tissue tropism, Microbiology, vol.153, pp.959-967, 2007.

S. W. Naylor, J. C. Low, T. E. Besser, A. Mahajan, G. J. Gunn et al., Lymphoid follicle-dense mucosa at the terminal rectum is the principal site of colonization of enterohemorrhagic Escherichia coli O157:H7 in the bovine host, Infect. Immun, vol.71, pp.1505-1512, 2003.

L. Nicholls, T. H. Grant, and R. M. Robins-browne, Identification of a novel genetic locus that is required for in vitro adhesion of a clinical isolate of enterohaemorrhagic Escherichia coli to epithelial cells, Mol. Microbiol, vol.35, pp.275-288, 2000.

J. C. Paton, P. , and A. W. , Pathogenesis and diagnosis of Shiga toxinproducing Escherichia coli infections, Clin. Microbiol. Rev, vol.11, pp.450-479, 1998.

A. D. Phillips, S. Navabpour, S. Hicks, G. Dougan, T. Wallis et al., Enterohaemorrhagic Escherichia coli O157:H7 target Peyer's patches in humans and cause attaching/effacing lesions in both human and bovine intestine, Gut, vol.47, pp.377-381, 2000.

N. Pradel, Y. Bertin, C. Martin, and V. Livrelli, Molecular analysis of shiga toxin-producing Escherichia coli strains isolated from hemolytic-uremic syndrome patients and dairy samples in France, Appl. Environ. Microbiol, vol.74, pp.2118-2128, 2008.

N. Pradel, S. Leroy-setrin, B. Joly, and V. Livrelli, Genomic subtraction to identify and characterize sequences of Shiga toxin-producing Escherichia coli O91:H21, Appl. Environ. Microbiol, vol.68, pp.2316-2325, 2002.

N. Pradel, V. Livrelli, C. De-champs, J. B. Palcoux, A. Reynaud et al., Prevalence and characterization of Shiga toxin-producing Escherichia coli isolated from cattle, food, and children during a one-year prospective study in France, J. Clin. Microbiol, vol.38, pp.1023-1031, 2000.

J. M. Rangel, P. H. Sparling, C. Crowe, P. M. Griffin, and D. L. Swerdlow, Epidemiology of Escherichia coli O157:H7 outbreaks, 1982.

, Emerg. Infect. Dis, vol.11, pp.603-609

I. M. Szalo, F. Goffaux, V. Pirson, D. Piérard, H. Ball et al., Presence in bovine enteropathogenic (EPEC) and enterohaemorrhagic (EHEC) Escherichia coli of genes encoding for putative adhesins of human EHEC strains, Res. Microbiol, vol.153, pp.653-658, 2002.

P. I. Tarr, S. S. Bilge, J. C. Vary, S. Jelacic, R. L. Habeeb et al., Iha: a novel Escherichia coli O157:H7 adherence-conferring molecule encoded on a recently acquired chromosomal island of conserved structure, Infect. Immun, vol.68, pp.1400-1407, 2000.

P. I. Tarr, M. A. Neill, C. R. Clausen, J. W. Newland, R. J. Neill et al., Genotypic variation in pathogenic Escherichia coli O157:H7 isolated from patients in Washington, 1984-1987, J. Infect. Dis, vol.159, pp.344-347, 1989.

J. Thevenot, L. Etienne-mesmin, S. Denis, S. Chalancon, M. Alric et al., Enterohemorrhagic Escherichia coli O157:H7 survival in an in vitro model of the human large intestine and interactions with probiotic yeasts and resident microbiota, Appl. Environ. Microbiol, vol.79, pp.1058-1064, 2013.
URL : https://hal.archives-ouvertes.fr/hal-02645425

C. Toma, E. Martinez-espinosa, T. Song, E. Miliwebsky, I. Chinen et al., Distribution of putative adhesins in different seropathotypes of Shiga toxin-producing Escherichia coli, J. Clin. Microbiol, vol.42, pp.4937-4946, 2004.

A. G. Torres, L. Milflores-flores, J. G. Garcia-gallegos, S. D. Patel, A. Best et al., Environmental regulation and colonization attributes of the long polar fimbriae (LPF) of Escherichia coli O157:H7, Int. J. Med. Microbiol, vol.297, pp.177-185, 2007.

H. Trachtman, C. Austin, M. Lewinski, and R. A. Stahl, Renal and neurological involvement in typical Shiga toxin-associated HUS, Nat. Rev. Nephrol, vol.8, pp.658-669, 2012.

D. K. Winsor, S. Ashkenazi, R. Chiovetti, and T. G. Cleary, Adherence of enterohemorrhagic Escherichia coli strains to a human colonic epithelial cell line (T84), Infect. Immun, vol.60, pp.1613-1617, 1992.

J. Xicohtencatl-cortes, V. Monteiro-neto, M. A. Ledesma, D. M. Jordan, O. Francetic et al., Intestinal adherence associated with type IV pili of enterohemorrhagic Escherichia coli O157:H7, J. Clin. Invest, vol.117, pp.3519-3529, 2007.

J. Xicohtencatl-cortes, V. Monteiro-neto, Z. Saldana, M. A. Ledesma, J. L. Puente et al., The type 4 pili of enterohemorrhagic Escherichia coli O157:H7 are multipurpose structures with pathogenic attributes, J. Bacteriol, vol.191, pp.411-421, 2009.

J. Xicohtencatl-cortes, Z. Saldana, W. Deng, E. Castaneda, E. Freer et al., Bacterial macroscopic rope-like fibers with cytopathic and adhesive properties, J. Biol. Chem, vol.285, pp.32336-32342, 2010.

T. Yamamoto, N. Wakisaka, F. Sato, and A. Kato, Comparison of the nucleotide sequence of enteroaggregative Escherichia coli heat-stable enterotoxin 1 genes among diarrhea-associated Escherichia coli, FEMS Microbiol. Lett, vol.147, pp.89-95, 1997.

, Conflict of Interest Statement: The authors declare that the research was conducted