Forests and trees throughout the world are increasingly affected by factors related to global change. Expanding international trade has facilitated invasions of numerous insects and pathogens into new regions. Many of these invasions have caused substantial forest damage, economic impacts and losses of ecosystem goods and services provided by trees. Climate change is already affecting the geographic distribution of host trees and their associated insects and pathogens, with anticipated increases in pest impacts by both native and invasive pests. Although climate change will benefit many forest insects, changes in thermal conditions may disrupt evolved life history traits and cause phenological mismatches. Individually, the threats posed to forest ecosystems by invasive pests and climate change are serious. Although interactions between these two drivers and their outcomes are poorly understood and hence difficult to predict, it is clear that the cumulative impacts on forest ecosystems will be exacerbated. Here we introduce and synthesize the information in this special issue of Forestry with articles that illustrate the impacts of invasions of insects and pathogens, climate change, forest management and their interactions, as well as methods to predict, assess and mitigate these impacts. Most of these contributions were presented at the XXIV IUFRO World Congress in 2014.