The GOLIATH Project: Towards an Internationally Harmonised Approach for Testing Metabolism Disrupting Compounds - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Accéder directement au contenu
Article Dans Une Revue International Journal of Molecular Sciences Année : 2020

The GOLIATH Project: Towards an Internationally Harmonised Approach for Testing Metabolism Disrupting Compounds

Daniel Zalko
Fabien Jourdan
Bernard Fromenty
  • Fonction : Auteur
  • PersonId : 945308
Claire Beausoleil
  • Fonction : Auteur
  • PersonId : 1008792
Sylvie Rémy
  • Fonction : Auteur
  • PersonId : 1205461
Sibylle Ermler
  • Fonction : Auteur
  • PersonId : 1071223
Luigi Margiotta-Casaluci
  • Fonction : Auteur
  • PersonId : 1071224
Patrik L Andersson
  • Fonction : Auteur
  • PersonId : 1071225

Résumé

The purpose of this project report is to introduce the European "GOLIATH" project, a new research project which addresses one of the most urgent regulatory needs in the testing of endocrine-disrupting chemicals (EDCs), namely the lack of methods for testing EDCs that disrupt metabolism and metabolic functions. These chemicals collectively referred to as "metabolism Int. Int. J. Mol. Sci. 2020, 21, 3480 2 of 18 disrupting compounds" (MDCs) are natural and anthropogenic chemicals that can promote metabolic changes that can ultimately result in obesity, diabetes, and/or fatty liver in humans. This project report introduces the main approaches of the project and provides a focused review of the evidence of metabolic disruption for selected EDCs. GOLIATH will generate the world's first integrated approach to testing and assessment (IATA) specifically tailored to MDCs. GOLIATH will focus on the main cellular targets of metabolic disruption-hepatocytes, pancreatic endocrine cells, myocytes and adipocytes-and using an adverse outcome pathway (AOP) framework will provide key information on MDC-related mode of action by incorporating multi-omic analyses and translating results from in silico, in vitro, and in vivo models and assays to adverse metabolic health outcomes in humans at real-life exposures. Given the importance of international acceptance of the developed test methods for regulatory use, GOLIATH will link with ongoing initiatives of the Organisation for Economic Development (OECD) for test method (pre-)validation, IATA, and AOP development.
Fichier principal
Vignette du fichier
2020_ijms_legler.pdf (1.38 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...

Dates et versions

hal-02638423 , version 1 (28-05-2020)
hal-02638423 , version 2 (28-03-2023)

Licence

Paternité

Identifiants

Citer

Juliette Legler, Daniel Zalko, Fabien Jourdan, Miriam Jacobs, Bernard Fromenty, et al.. The GOLIATH Project: Towards an Internationally Harmonised Approach for Testing Metabolism Disrupting Compounds. International Journal of Molecular Sciences, 2020, 21 (10), pp.3480. ⟨10.3390/ijms21103480⟩. ⟨hal-02638423v1⟩

Collections

INSERM
156 Consultations
42 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More