P. G. Holt, D. H. Strickland, M. E. Wikstrom, and F. L. Jahnsen, Regulation of immunological homeostasis in the respiratory tract, Nat Rev Immunol, vol.8, pp.142-52, 2008.

M. J. Holtzman, J. D. Morton, and L. P. Shornick, Immunity, inflammation, and remodeling in the airway epithelial barrier: epithelial-viral-allergic paradigm, Physiol Rev, vol.82, pp.19-46, 2002.

A. K. Mayer and A. H. Dalpke, Regulation of local immunity by airway epithelial cells, Arch Immunol Ther Exp (Warsz), vol.55, pp.353-62, 2007.

H. See and P. Wark, Innate immune response to viral infection of the lungs, Paediatr Respir Rev, vol.9, pp.243-50, 2008.

M. Mordstein, E. Neugebauer, and V. Ditt, Lambda interferon renders epithelial cells of the respiratory and gastrointestinal tracts resistant to viral infections, J Virol, vol.84, pp.5670-5677, 2010.

R. E. Randall and S. Goodbourn, Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures, J Gen Virol, vol.89, pp.1-47, 2008.

R. Bals and P. S. Hiemstra, Innate immunity in the lung: how epithelial cells fight against respiratory pathogens, Eur Respir J, vol.23, pp.327-360, 2004.

S. L. Johnston, Overview of virus-induced airway disease, Proc Am Thorac Soc, vol.2, pp.150-156, 2005.

R. J. Mason, Biology of alveolar type II cells, Respirology, vol.11, pp.12-17, 2006.

T. A. Miura, J. Wang, K. V. Holmes, and R. J. Mason, Rat coronaviruses infect rat alveolar type I epithelial cells and induce expression of CXC chemokines, Virology, vol.369, pp.288-98, 2007.

J. Wang, R. Oberley-deegan, and S. Wang, Differentiated human alveolar type II cells secrete antiviral IL-29 (IFN-lambda 1) in response to influenza A infection, J Immunol, vol.182, pp.1296-304, 2009.

E. C. Crouch, Surfactant protein-D and pulmonary host defense, Respir Res, vol.1, pp.93-108, 2000.

M. Doss, M. R. White, and T. Tecle, Interactions of alpha-, beta-, and theta-defensins with influenza A virus and surfactant protein D, J Immunol, vol.182, pp.7878-87, 2009.

U. Kishore, T. J. Greenhough, and P. Waters, Surfactant proteins SP-A and SP-D: structure, function and receptors, Mol Immunol, vol.43, pp.1293-315, 2006.

M. E. Klotman and T. L. Chang, Defensins in innate antiviral immunity, Nat Rev Immunol, vol.6, pp.447-56, 2006.

D. J. Griffiths, H. M. Martineau, and C. Cousens, Pathology and pathogenesis of ovine pulmonary adenocarcinoma, J Comp Pathol, vol.142, pp.260-83, 2010.

W. L. Read, N. C. Page, R. M. Tierney, J. F. Piccirillo, and R. Govindan, The epidemiology of bronchioloalveolar carcinoma over the past two decades: analysis of the SEER database, Lung Cancer, vol.45, pp.137-179, 2004.

J. F. Mornex, F. Thivolet, M. De-las-heras, and C. Leroux, Pathology of human bronchioloalveolar carcinoma and its relationship to the ovine disease, Curr Top Microbiol Immunol, vol.275, pp.225-273, 2003.

C. Bonne, Morphological resemblance of pulmonary adenomatosis (jaaksiekte) in sheep and certain cases of cancer of the lung in man, Am J Cancer, vol.35, pp.491-501, 1939.

M. Wislez, V. Gounant, J. Cadranel, and . Bronchioloalveolar, Rev Mal Respir, vol.22, pp.8-70, 2005.

M. De-las-heras, S. H. Barsky, and P. Hasleton, Evidence for a protein related immunologically to the jaagsiekte sheep retrovirus in some human lung tumours, Eur Respir J, vol.16, pp.330-332, 2000.

K. M. Hiatt and W. E. Highsmith, Lack of DNA evidence for jaagsiekte sheep retrovirus in human bronchioloalveolar carcinoma, Hum Pathol, vol.33, p.680, 2002.

S. A. Yousem, S. D. Finkelstein, P. A. Swalsky, A. Bakker, and N. Ohori, Absence of jaagsiekte sheep retrovirus DNA and RNA in bronchioloalveolar and conventional human pulmonary adenocarcinoma by PCR and RT-PCR analysis, Hum Pathol, vol.32, pp.1039-1081, 2001.

J. A. Platt, N. Kraipowich, F. Villafane, and J. C. Demartini, Alveolar type II cells expressing jaagsiekte sheep retrovirus capsid protein and surfactant proteins are the predominant neoplastic cell type in ovine pulmonary adenocarcinoma, Vet Pathol, vol.39, pp.341-52, 2002.

M. Palmarini, M. J. Holland, C. Cousens, R. G. Dalziel, and J. M. Sharp, Jaagsiekte retrovirus establishes a disseminated infection of the lymphoid tissues of sheep affected by pulmonary adenomatosis, J Gen Virol, vol.77, pp.2991-2999, 1996.

M. J. Holland, M. Palmarini, and M. Garcia-goti, Jaagsiekte retrovirus is widely distributed both in T and B lymphocytes and in mononuclear phagocytes of sheep with naturally and experimentally acquired pulmonary adenomatosis, J Virol, vol.73, pp.4004-4012, 1999.

S. K. Rai, F. M. Duh, V. Vigdorovich, A. Danilkovitch-miagkova, M. I. Lerman et al., Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation, Proc Natl Acad Sci U S A, vol.98, pp.4443-4451, 2001.

S. J. Hecht, K. E. Stedman, J. O. Carlson, and J. C. Demartini, Distribution of endogenous type B and type D sheep retrovirus sequences in ungulates and other mammals, Proc Natl Acad Sci, vol.93, pp.3297-302, 1996.

M. Palmarini, C. Hallwirth, and D. York, Molecular cloning and functional analysis of three type D endogenous retroviruses of sheep reveal a different cell tropism from that of the highly related exogenous jaagsiekte sheep retrovirus, J Virol, vol.74, pp.8065-76, 2000.

C. Leroux, N. Girard, V. Cottin, T. Greenland, J. F. Mornex et al.,

, Jaagsiekte Sheep Retrovirus (JSRV): from virus to lung cancer in sheep, Vet Res, vol.38, pp.211-239, 2007.

S. K. Wootton, C. L. Halbert, and A. D. Miller, Sheep retrovirus structural protein induces lung tumours, Nature, vol.434, pp.904-911, 2005.

M. Caporale, C. Cousens, P. Centorame, C. Pinoni, M. De-las-heras et al., Expression of the jaagsiekte sheep retrovirus envelope glycoprotein is sufficient to induce lung tumors in sheep, J Virol, vol.80, pp.8030-8037, 2006.

N. Maeda, M. Palmarini, C. Murgia, and H. Fan, Direct transformation of rodent fibroblasts by jaagsiekte sheep retrovirus DNA, Proc Natl Acad Sci U S A, vol.98, pp.4449-54, 2001.

T. E. Allen, K. J. Sherrill, S. M. Crispell, M. R. Perrott, J. O. Carlson et al., The jaagsiekte sheep retrovirus envelope gene induces transformation of the avian fibroblast cell line DF-1 but does not require a conserved SH2 binding domain, J Gen Virol, vol.83, pp.2733-2775, 2002.

G. Zavala, C. Pretto, and Y. H. Chow, Relevance of Akt phosphorylation in cell transformation induced by Jaagsiekte sheep retrovirus, Virology, vol.312, pp.95-105, 2003.

A. Danilkovitch-miagkova, F. M. Duh, and I. Kuzmin,

, Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus, Proc Natl Acad Sci U S A, vol.100, pp.4580-4585, 2003.

S. L. Liu and A. D. Miller, Transformation of madin-darby canine kidney epithelial cells by sheep retrovirus envelope proteins, J Virol, vol.79, pp.927-960, 2005.

N. Maeda, W. Fu, A. Ortin, M. De-las-heras, and H. Fan, Roles of the Ras-MEK-mitogen-activated protein kinase and phosphatidylinositol 3-kinase-Akt-mTOR pathways in Jaagsiekte sheep retrovirus-induced transformation of rodent fibroblast and epithelial cell lines, J Virol, vol.79, pp.4440-50, 2005.

Y. H. Chow, A. Alberti, and M. Mura, Transformation of rodent fibroblasts by the jaagsiekte sheep retrovirus envelope is receptor independent and does not require the surface domain, J Virol, vol.77, pp.6341-50, 2003.

A. Hofacre and H. Fan, Multiple domains of the Jaagsiekte sheep retrovirus envelope protein are required for transformation of rodent fibroblasts, J Virol, vol.78, pp.10479-89, 2004.

S. Hull and H. Fan, Mutational analysis of the cytoplasmic tail of jaagsiekte sheep retrovirus envelope protein, J Virol, vol.80, pp.8069-80, 2006.

M. Palmarini, N. Maeda, C. Murgia, C. De-fraja, A. Hofacre et al., A phosphatidylinositol 3-kinase docking site in the cytoplasmic tail of the Jaagsiekte sheep retrovirus transmembrane protein is essential for envelope-induced transformation of NIH 3T3 cells, J Virol, vol.75, pp.11002-11011, 2001.

S. L. Liu, M. I. Lerman, and A. D. Miller, Putative phosphatidylinositol 3-kinase (PI3K) binding motifs in ovine betaretrovirus Env proteins are not essential for rodent fibroblast transformation and PI3K/Akt activation, J Virol, vol.77, pp.7924-7959, 2003.

F. Archer, E. Jacquier, and M. Lyon, Alveolar type II cells isolated from pulmonary adenocarcinoma: a model for JSRV expression in vitro, Am J Respir Cell Mol Biol, vol.36, pp.534-574, 2007.
URL : https://hal.archives-ouvertes.fr/hal-02661850

F. Suau, V. Cottin, and F. Archer, Telomerase activation in a model of lung adenocarcinoma, Eur Respir J, vol.27, pp.1175-82, 2006.
URL : https://hal.archives-ouvertes.fr/hal-02667534

C. Summers, W. Neill, and P. Dewar, Systemic immune responses following infection with Jaagsiekte sheep retrovirus and in the terminal stages of ovine pulmonary adenocarcinoma, J Gen Virol, vol.83, pp.1753-1760, 2002.

R. H. Rosadio and J. M. Sharp, Leukocyte frequency alterations in sheep with naturally and experimentally induced lung cancer, Veterinary Medicine, pp.46-51, 1992.

C. Summers, M. Norval, M. De-las-heras, L. Gonzalez, J. M. Sharp et al., An influx of macrophages is the predominant local immune response in ovine pulmonary adenocarcinoma, Vet Immunol Immunopathol, vol.106, pp.285-94, 2005.

M. S. Myer, H. F. Huchzermeyer, D. F. York, P. Hunter, D. W. Verwoerd et al., The possible involvement of immunosuppression caused by a lentivirus in the aetiology of jaagsiekte and pasteurellosis in sheep, Onderstepoort J Vet Res, vol.55, pp.127-160, 1988.

B. Salaun, B. De-saint-vis, and N. Pacheco, CD208/dendritic celllysosomal associated membrane protein is a marker of normal and transformed type II pneumocytes, Am J Pathol, vol.164, pp.861-71, 2004.
URL : https://hal.archives-ouvertes.fr/hal-02679874

N. Barois, B. De-saint-vis, S. Lebecque, H. J. Geuze, and M. J. Kleijmeer, MHC class II compartments in human dendritic cells undergo profound structural changes upon activation, Traffic, vol.3, pp.894-905, 2002.

B. De-saint-vis, J. Vincent, and S. Vandenabeele, A novel lysosome-associated membrane glycoprotein, DC-LAMP, induced upon DC maturation, is transiently expressed in MHC class II compartment, Immunity, vol.9, pp.325-361, 1998.

A. C. Cunningham, D. S. Milne, J. Wilkes, J. H. Dark, T. D. Tetley et al., Constitutive expression of MHC and adhesion molecules by alveolar epithelial cells (type II pneumocytes) isolated from human lung and comparison with immunocytochemical findings, J Cell Sci, vol.107, issue.2, pp.443-452, 1994.

E. E. Schneeberger, M. Deferrari, M. J. Skoskiewicz, P. S. Russell, and R. B. Colvin, Induction of MHC-determined antigens in the lung by interferon-gamma, Lab Invest, vol.55, pp.138-182, 1986.

E. Arbustini, P. Morbini, and M. Diegoli, Coexpression of aspartic proteinases and human leukocyte antigen-DR in human transplanted lung, Am J Pathol, vol.145, pp.310-331, 1994.

T. Komatsu, M. Yamamoto, K. Shimokata, and H. Nagura, Phenotypic characterization of alveolar capillary endothelial cells, alveolar epithelial cells and alveolar macrophages in patients with pulmonary fibrosis, with special reference to MHC class II antigens, Virchows Arch A Pathol Anat Histopathol, vol.415, pp.79-90, 1989.

J. Guzman, T. Izumi, S. Nagai, and U. Costabel, ICAM-1 and integrin expression on isolated human alveolar type II pneumocytes, Eur Respir J, vol.7, pp.736-745, 1994.

G. Zissel, M. Ernst, and K. Rabe, Human alveolar epithelial cells type II are capable of regulating T-cell activity, J Investig Med, vol.48, pp.66-75, 2000.

D. W. Verwoerd, A. L. Payne, D. F. York, and M. S. Myer, Isolation and preliminary characterization of the jaagsiekte retrovirus (JSRV)

, Onderstepoort J Vet Res, vol.50, pp.309-325, 1983.

S. Rosati, J. Kwang, F. Tolari, and J. Keen, Characterization of enzootic nasal tumor virus capsid antigen, Vet Microbiol, vol.53, pp.261-270, 1996.

J. Kwang, S. Rosati, S. Yang, R. A. Juste, and A. De-la-concha-bermejillo, Recognition of ovine lentivirus gag gene products by serum from infected sheep, Vet Immunol Immunopathol, vol.55, pp.107-121, 1996.

J. M. Sharp and A. J. Herring, Sheep pulmonary adenomatosis: demonstration of a protein which cross-reacts with the major core proteins of Mason-Pfizer monkey virus and mouse mammary tumour virus, J Gen Virol, vol.64, pp.2323-2330, 1983.

J. C. Demartini, R. H. Rosadio, and M. D. Lairmore, The etiology and pathogenesis of ovine pulmonary carcinoma (sheep pulmonary adenomatosis), Vet Microbiol, vol.17, pp.219-255, 1988.

D. W. Verwoerd and . In, Virus Infections of Ruminants. Dento Z, Mosein B, pp.453-62, 1990.

M. De-las-heras, G. De-jalon, J. A. Minguijon, E. Gray, E. W. Dewar et al., Experimental transmission of enzootic intranasal tumors of goats, Vet Pathol, vol.32, pp.19-23, 1995.

A. Ortin, E. Minguijon, and P. Dewar, Lack of a specific immune response against a recombinant capsid protein of Jaagsiekte sheep retrovirus in sheep and goats naturally affected by enzootic nasal tumour or sheep pulmonary adenomatosis, Vet Immunol Immunopathol, vol.61, pp.229-266, 1998.

J. M. Sharp and J. C. Demartini, Natural history of JSRV in sheep, Curr Top Microbiol Immunol, vol.275, pp.55-79, 2003.

C. Summers, P. Dewar, and R. Van-der-molen, Jaagsiekte sheep retrovirus-specific immune responses induced by vaccination: a comparison of immunisation strategies, Vaccine, vol.24, pp.1821-1830, 2006.

J. C. Demartini, J. O. Carlson, C. Leroux, T. Spencer, and M. Palmarini, Endogenous retroviruses related to jaagsiekte sheep retrovirus, Curr Top Microbiol Immunol, vol.275, pp.117-154, 2003.

P. R. Murcia, F. Arnaud, and M. Palmarini, The transdominant endogenous retrovirus enJS56A1 associates with and blocks intracellular trafficking of Jaagsiekte sheep retrovirus Gag, J Virol, vol.81, pp.1762-72, 2007.
URL : https://hal.archives-ouvertes.fr/hal-01601223

K. A. Dunlap, M. Palmarini, and M. Varela, Endogenous retroviruses regulate periimplantation placental growth and differentiation, Proc Natl Acad Sci, vol.103, pp.14390-14395, 2006.

D. York, R. Vigne, D. W. Verwoerd, and G. Querat, Nucleotide sequence of the jaagsiekte retrovirus, an exogenous and endogenous type D and B retrovirus of sheep and goats, J Virol, vol.66, pp.4930-4939, 1992.

J. Carlson, M. Lyon, and J. Bishop, Chromosomal distribution of endogenous Jaagsiekte sheep retrovirus proviral sequences in the sheep genome, J Virol, vol.77, pp.9662-9670, 2003.
URL : https://hal.archives-ouvertes.fr/hal-02676904

M. Palmarini, M. Mura, and T. E. Spencer, Endogenous betaretroviruses of sheep: teaching new lessons in retroviral interference and adaptation, J Gen Virol, vol.85, pp.1-13, 2004.