J. Baker, J. P. Liu, E. J. Robertson, and A. Efstratiadis, Role of insulin-like growth factors in embryonic and postnatal growth, Cell, vol.75, pp.73-82, 1993.

F. J. Ballard, G. L. Francis, M. Ross, C. J. Bagley, B. May et al., Natural and synthetic forms of insulin-like growth factor-1 (IGF-1) and the potent derivative, destripeptide IGF-1: biological activities and receptor binding, Biochem. Biophys. Res. Commun, vol.149, pp.398-404, 1987.

F. J. Ballard, M. Ross, F. M. Upton, and G. L. Francis, Specific binding of insulin-like growth factors 1 and 2 to the type 1 and type 2 receptors respectively, Biochem. J, vol.249, pp.721-726, 1988.

F. J. Ballard, S. E. Knowles, P. E. Walton, K. Edson, P. C. Owens et al., Plasma clearance and tissue distribution of labelled insulinlike growth factor-I (IGF-I), IGF-II and des(1-3)IGF-I in rats, J. Endocrinol, vol.128, pp.197-204, 1991.

S. E. Bastian, P. E. Walton, J. C. Wallace, and F. J. Ballard, Plasma clearance and tissue distribution of labelled insulin-like growth factor-I (IGF-I) and an analogue LR3IGF-I in pregnant rats, J. Endocrinol, vol.138, pp.327-336, 1993.

R. C. Baxter, Insulin-like growth factor (IGF)-binding proteins: interactions with IGFs and intrinsic bioactivities, Am. J. Physiol. Endocrinol. Metab, vol.278, pp.967-976, 2000.

R. C. Baxter and J. L. Martin, Structure of the Mr 140,000 growth hormonedependent insulin-like growth factor binding protein complex: determination by reconstitution and affinity-labeling, Proc. Natl. Acad. Sci. USA, vol.86, pp.6898-6902, 1989.

M. L. Bayne, J. Applebaum, D. Underwood, G. G. Chicchi, B. G. Green et al., The C region of human insulin-like growth factor (IGF) I is required for high affinity binding to the type 1 IGF receptor, J. Biol. Chem, vol.264, pp.11004-11008, 1989.

G. E. Butterfield, J. Thompson, M. J. Rennie, R. Marcus, R. L. Hintz et al., Effect of rhGH and rhIGF-I treatment on protein utilization in elderly women, Am. J. Physiol, vol.272, pp.94-99, 1997.

J. W. Chen, T. Ledet, H. Orskov, N. Jessen, S. Lund et al., A highly sensitive and specific assay for determination of IGF-I bioactivity in human serum, Am. J. Physiol. Endocrinol. Metab, vol.284, pp.1149-1155, 2003.

R. M. Cooke, T. S. Harvey, and I. D. Campbell, Solution structure of human insulin-like growth factor 1, a nuclear magnetic resonance and restrained molecular dynamics study, Biochemistry, vol.30, pp.5484-5491, 1991.

S. A. Coolican, D. S. Samuel, D. Z. Ewton, F. J. Mcwade, and J. R. Florini, The mitogenic and myogenic actions of insulin-like growth factors utilize distinct signaling pathways, J. Biol. Chem, vol.272, pp.6653-6662, 1997.

, Disease Models & Mechanisms

H. W. Courtland, V. Demambro, J. Maynard, H. Sun, S. Elis et al., Sex-specific regulation of body size and bone slenderness by the acid labile subunit, J. Bone Miner. Res, vol.25, pp.2059-2068, 2010.
URL : https://hal.archives-ouvertes.fr/hal-02666501

D. M. Crist and J. M. Hill, Diet and insulinlike growth factor I in relation to body composition in women with exercise-induced hypothalamic amenorrhea, J. Am. Coll. Nutr, vol.9, pp.200-204, 1990.

H. M. Domene, S. V. Bengolea, A. S. Martinez, M. G. Ropelato, P. Pennisi et al., Deficiency of the circulating insulin-like growth factor system associated with inactivation of the acid-labile subunit gene, N. Engl. J. Med, vol.350, pp.570-577, 2004.

H. M. Domene, V. Hwa, J. Argente, J. M. Wit, C. Camacho-hubner et al., Human acid-labile subunit deficiency: clinical, endocrine and metabolic consequences, Horm. Res, vol.72, pp.129-141, 2009.

D. J. Flint, E. Tonner, J. Beattie, and M. Gardner, Several insulin-like growth factor-I analogues and complexes of insulin-like growth factors-I and -II with insulinlike growth factor-binding protein-3 fail to mimic the effect of growth hormone upon lactation in the rat, J. Endocrinol, vol.140, pp.211-216, 1994.

K. Forbes and M. Westwood, The IGF axis and placental function. a mini review, Horm. Res, vol.69, pp.129-137, 2008.

G. L. Francis, J. P. Mcmurtry, R. J. Johnson, and F. J. Ballard, Plasma clearance of chicken and human insulin-like growth factor-I and their association with circulating binding proteins in chickens, J. Endocrinol, vol.124, pp.361-370, 1990.

J. Frystyk, Aging somatotropic axis: mechanisms and implications of insulinlike growth factor-related binding protein adaptation, Endocrinol. Metab. Clin. North Am, vol.34, pp.865-876, 2005.

C. Gillespie, L. C. Read, C. J. Bagley, and F. J. Ballard, Enhanced potency of truncated insulin-like growth factor-I (des(1-3)IGF-I) relative to IGF-I in lit/lit mice, J. Endocrinol, vol.127, pp.401-405, 1990.

D. L. Hadsell, N. M. Greenberg, J. M. Fligger, C. R. Baumrucker, and J. M. Rosen, Targeted expression of des(1-3) human insulin-like growth factor I in transgenic mice influences mammary gland development and IGF-binding protein expression, Endocrinology, vol.137, pp.321-330, 1996.

K. J. Jepsen, B. Hu, S. M. Tommasini, H. W. Courtland, C. Price et al., Genetic randomization reveals functional relationships among morphologic and tissue-quality traits that contribute to bone strength and fragility, Mamm. Genome, vol.18, pp.492-507, 2007.

R. Kaaks, Nutrition, insulin, IGF-1 metabolism and cancer risk: a summary of epidemiological evidence, Novartis Found. Symp, vol.262, pp.247-260, 2004.

R. King, J. R. Wells, P. Krieg, M. Snoswell, J. Brazier et al., Production and characterization of recombinant insulin-like growth factor-I (IGF-I) and potent analogues of IGF-I, with Gly or Arg substituted for Glu3, following their expression in Escherichia coli as fusion proteins, J. Mol. Endocrinol, vol.8, pp.29-41, 1992.

I. Kreitschmann-andermahr, P. Suarez, R. Jennings, N. Evers, and G. Brabant, GH/IGF-I regulation in obesity-mechanisms and practical consequences in children and adults, Horm. Res. Paediatr, vol.73, pp.153-160, 2010.

A. B. Lemmey, A. A. Martin, L. C. Read, F. M. Tomas, P. C. Owens et al., IGF-I and the truncated analogue des-(1-3)IGF-I enhance growth in rats after gut resection, Am. J. Physiol, vol.260, pp.213-219, 1991.

J. L. Liu, A. Grinberg, H. Westphal, B. Sauer, D. Accili et al., Insulin-like growth factor-I affects perinatal lethality and postnatal development in a gene dosage-dependent manner: manipulation using the Cre/loxP system in transgenic mice, Mol. Endocrinol, vol.12, pp.1452-1462, 1998.

P. Liu, N. A. Jenkins, and N. G. Copeland, A highly efficient recombineeringbased method for generating conditional knockout mutations, Genome Res, vol.13, pp.476-484, 2003.

L. S. Mathews, R. E. Hammer, R. R. Behringer, A. J. D'ercole, G. I. Bell et al., Growth enhancement of transgenic mice expressing human insulin-like growth factor I, Endocrinology, vol.123, pp.2827-2833, 1988.

R. H. Mccusker, M. Kaleko, and R. L. Sackett, Multivalent cations and ligand affinity of the type 1 insulin-like growth factor receptor on P2A2-LISN muscle cells, J. Cell Physiol, vol.176, pp.392-401, 1998.

S. Mohan and D. J. Baylink, IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms, J. Endocrinol, vol.175, pp.19-31, 2002.

Y. Ning, A. G. Schuller, S. Bradshaw, P. Rotwein, T. Ludwig et al., Diminished growth and enhanced glucose metabolism in triple knockout mice containing mutations of insulin-like growth factor binding protein-3, -4, and -5, Mol. Endocrinol, vol.20, pp.2173-2186, 2006.

P. Pennisi, O. Gavrilova, J. Setser-portas, W. Jou, S. Santopietro et al., Recombinant human insulin-like growth factor-I treatment inhibits gluconeogenesis in a transgenic mouse model of type 2 diabetes mellitus, Endocrinology, vol.147, pp.2619-2630, 2006.

M. Ross, G. L. Francis, L. Szabo, J. C. Wallace, and F. J. Ballard, Insulin-like growth factor (IGF)-binding proteins inhibit the biological activities of IGF-1 and IGF-2 but not des-(1-3)-IGF-1, Biochem. J, vol.258, pp.267-272, 1989.

A. Sato, S. Nishimura, T. Ohkubo, Y. Kyogoku, S. Koyama et al., Three-dimensional structure of human insulinlike growth factor-I (IGF-I) determined by 1H-NMR and distance geometry, Int. J. Pept. Protein Res, vol.41, pp.433-440, 1993.

E. Stratikopoulos, M. Szabolcs, I. Dragatsis, A. Klinakis, and A. Efstratiadis, The hormonal action of IGF1 in postnatal mouse growth, Proc. Natl. Acad. Sci. USA 105, pp.19378-19383, 2008.

B. F. Sun, H. Kobayashi, N. Le, T. M. Yoo, D. Drumm et al., Biodistribution of 125I-labeled des(1-3) insulin-like growth factor I in tumor-bearing nude mice and its in vitro catabolism, Cancer Res, vol.57, pp.2754-2759, 1997.

L. Szabo, D. G. Mottershead, F. J. Ballard, and J. C. Wallace, The bovine insulin-like growth factor (IGF) binding protein purified from conditioned medium requires the N-terminal tripeptide in IGF-1 for binding, Biochem. Biophys. Res. Commun, vol.151, pp.207-214, 1988.

J. L. Thompson, G. E. Butterfield, R. Marcus, R. L. Hintz, M. Van-loan et al., The effects of recombinant human insulin-like growth factor-I and growth hormone on body composition in elderly women, J. Clin. Endocrinol. Metab, vol.80, pp.1845-1852, 1995.

K. Wakai, K. Suzuki, Y. Ito, Y. Watanabe, Y. Inaba et al., Time spent walking or exercising and blood levels of insulinlike growth factor-I (IGF-I) and IGF-binding protein-3 (IGFBP-3): a large-scale crosssectional study in the Japan Collaborative Cohort study. Asian Pac, J. Cancer Prev, p.10, 2009.

K. A. Woods, C. Camacho-hubner, M. O. Savage, and A. J. Clark, Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene, N. Engl. J. Med, vol.335, pp.1363-1367, 1996.

S. Yakar, J. L. Liu, A. M. Fernandez, Y. Wu, A. V. Schally et al., Liver-specific igf-1 gene deletion leads to muscle insulin insensitivity, Diabetes, vol.50, pp.1110-1118, 2001.

S. Yakar, C. J. Rosen, W. G. Beamer, C. L. Ackert-bicknell, Y. Wu et al., Circulating levels of IGF-1 directly regulate bone growth and density, J. Clin. Invest, vol.110, pp.771-781, 2002.

S. Yakar, Y. Wu, J. Setser, and C. J. Rosen, The role of circulating IGF-I: lessons from human and animal models, Endocrine, vol.19, pp.239-248, 2002.

S. Yakar, J. Setser, H. Zhao, B. Stannard, M. Haluzik et al., Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient mice, J. Clin. Invest, vol.113, pp.96-105, 2004.

S. Yakar, H. Kim, H. Zhao, Y. Toyoshima, P. Pennisi et al., The growth hormone-insulin like growth factor axis revisited: lessons from IGF-1 and IGF-1 receptor gene targeting, Pediatr. Nephrol, vol.20, pp.251-254, 2005.

S. Yakar, D. Leroith, and P. Brodt, The role of the growth hormone/insulinlike growth factor axis in tumor growth and progression: Lessons from animal models, Cytokine Growth Factor Rev, vol.16, pp.407-420, 2005.

S. Yakar, M. L. Bouxsein, E. Canalis, H. Sun, V. Glatt et al., The ternary IGF complex influences postnatal bone acquisition and the skeletal response to intermittent parathyroid hormone, J. Endocrinol, vol.189, pp.289-299, 2006.

S. Yakar, E. Canalis, H. Sun, W. Mejia, Y. Kawashima et al., Serum IGF-1 determines skeletal strength by regulating subperiosteal expansion and trait interactions, J. Bone Miner. Res, vol.24, pp.1481-1492, 2009.

S. Yakar, C. J. Rosen, M. L. Bouxsein, H. Sun, W. Mejia et al., Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism, FASEB J, vol.23, pp.709-719, 2009.