J. R. Teijaro, K. B. Walsh, S. Cahalan, D. M. Fremgen, and E. Roberts, Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection, Cell, vol.146, pp.980-991, 2011.

L. Gruta, N. L. Kedzierska, K. Stambas, J. Doherty, and P. C. , A question of selfpreservation: immunopathology in influenza virus infection, Immunol Cell Biol, vol.85, pp.85-92, 2007.

J. Wei, J. Waithman, R. Lata, N. A. Mifsud, and J. Cebon, Influenza A infection enhances cross-priming of CD8+ T cells to cell-associated antigens in a TLR7-and type I IFN-dependent fashion, J Immunol, vol.185, pp.6013-6022, 2010.

A. Ballesteros-tato, B. Leon, F. E. Lund, and T. D. Randall, Temporal changes in dendritic cell subsets, cross-priming and costimulation via CD70 control CD8(+) T cell responses to influenza, Nat Immunol, vol.11, pp.216-224, 2010.

J. M. Lund, L. Alexopoulou, A. Sato, M. Karow, and N. C. Adams, Recognition of single-stranded RNA viruses by Toll-like receptor 7, Proc Natl Acad Sci, vol.101, pp.5598-5603, 2004.

S. Koyama, K. J. Ishii, H. Kumar, T. Tanimoto, and C. Coban, Differential role of TLR-and RLR-signaling in the immune responses to influenza A virus infection and vaccination, J Immunol, vol.179, pp.4711-4720, 2007.

S. S. Diebold, T. Kaisho, H. Hemmi, S. Akira, and C. Reis-e-sousa, Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA, Science, vol.303, pp.1529-1531, 2004.

V. Jeisy-scott, W. G. Davis, J. R. Patel, J. B. Bowzard, and W. J. Shieh, Increased MDSC accumulation and Th2 biased response to influenza A virus infection in the absence of TLR7 in mice, PloS one, vol.6, p.25242, 2011.

N. W. Palm and R. Medzhitov, Pattern recognition receptors and control of adaptive immunity, Immunol Rev, vol.227, pp.221-233, 2009.

T. Kawai and S. Akira, The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors, Nat Immunol, vol.11, pp.373-384, 2010.

C. A. Janeway and R. Medzhitov, Innate immune recognition, Annu Rev Immunol, vol.20, pp.197-216, 2002.

B. Park, M. M. Brinkmann, E. Spooner, C. C. Lee, and Y. M. Kim, Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9, Nat Immunol, vol.9, pp.1407-1414, 2008.

S. E. Ewald, B. L. Lee, L. Lau, K. E. Wickliffe, and G. P. Shi, The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor, Nature, vol.456, pp.658-662, 2008.

F. Matsumoto, S. Saitoh, R. Fukui, T. Kobayashi, and N. Tanimura, Cathepsins are required for Toll-like receptor 9 responses, Biochem Bioph Res Co, vol.367, pp.693-699, 2008.

M. Asagiri, T. Hirai, T. Kunigami, S. Kamano, and H. J. Gober, Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis, Science, vol.319, pp.624-627, 2008.

F. E. Sepulveda, S. Maschalidi, R. Colisson, L. Heslop, and C. Ghirelli, Critical role for asparagine endopeptidase in endocytic Toll-like receptor signaling in dendritic cells, Immunity, vol.31, pp.737-748, 2009.

S. E. Ewald, A. Engel, J. Lee, M. Wang, and M. Bogyo, Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase, The J Exp Med, vol.208, pp.643-651, 2011.

L. Guillot, L. Goffic, R. Bloch, S. Escriou, N. Akira et al., Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to doublestranded RNA and influenza A virus, J Biol Chem, vol.280, pp.5571-5580, 2005.

R. Sen and D. Baltimore, Inducibility of kappa immunoglobulin enhancerbinding protein Nf-kappa B by a posttranslational mechanism, Cell, vol.47, pp.921-928, 1986.

L. Goffic, R. Leymarie, O. Chevalier, C. Rebours, E. et al., Transcriptomic analysis of host immune and cell death responses associated with the influenza A virus PB1-F2 protein, PLoS Pathog, vol.7, p.1002202, 2011.
URL : https://hal.archives-ouvertes.fr/hal-00684735

K. Shirahama-noda, A. Yamamoto, K. Sugihara, N. Hashimoto, and M. Asano, Biosynthetic processing of cathepsins and lysosomal degradation are abolished in asparaginyl endopeptidase-deficient mice, J Biol Chem, vol.278, pp.33194-33199, 2003.

R. Maehr, H. C. Hang, J. D. Mintern, Y. M. Kim, and A. Cuvillier, Asparagine endopeptidase is not essential for class II MHC antigen presentation but is required for processing of cathepsin L in mice, J Immunol, vol.174, pp.7066-7074, 2005.

B. Hou, B. Reizis, and A. L. Defranco, Toll-like receptors activate innate and adaptive immunity by using dendritic cell-intrinsic and -extrinsic mechanisms, Immunity, vol.29, pp.272-282, 2008.

D. N. Li, S. P. Matthews, A. N. Antoniou, D. Mazzeo, and C. Watts, Multistep autoactivation of asparaginyl endopeptidase in vitro and in vivo, J Biol Chem, vol.278, pp.38980-38990, 2003.

A. Savina, C. Jancic, S. Hugues, P. Guermonprez, and P. Vargas, NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells, Cell, vol.126, pp.205-218, 2006.

A. Savina, A. Peres, I. Cebrian, N. Carmo, and C. Moita, The small GTPase Rac2 controls phagosomal alkalinization and antigen crosspresentation selectively in CD8(+) dendritic cells, Immunity, vol.30, pp.544-555, 2009.

M. Rutz, J. Metzger, T. Gellert, P. Luppa, and G. B. Lipford, Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence-and pH-dependent manner, Eur J Immunol, vol.4, pp.2541-2550, 2004.

B. Manoury, E. W. Hewitt, N. Morrice, P. M. Dando, and A. J. Barrett, An asparaginyl endopeptidase processes a microbial antigen for class II MHC presentation, Nature, vol.396, pp.695-699, 1998.

K. Tabeta, K. Hoebe, E. M. Janssen, X. Du, and P. Georgel, The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9, Nat Immunol, vol.7, pp.156-164, 2006.

T. Ichinohe, A. Iwasaki, and H. Hasegawa, Innate sensors of influenza virus: clues to developing better intranasal vaccines, Expert Rev Vaccines, vol.7, pp.1435-1445, 2008.

C. Ehrhardt, R. Seyer, E. R. Hrincius, T. Eierhoff, and T. Wolff, Interplay between influenza A virus and the innate immune signaling, Microbes Infect, vol.12, pp.81-87, 2010.

L. Goffic, R. Balloy, V. Lagranderie, M. Alexopoulou, L. Escriou et al., Detrimental contribution of the Toll-like receptor (TLR)3 to influenza A virusinduced acute pneumonia, PLoS Pathog, vol.2, p.53, 2006.

P. G. Thomas, P. Dash, J. R. Aldridge, J. Ellebedy, A. H. Reynolds et al., The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1, Immunity, vol.30, pp.566-575, 2009.

I. Jelinek, J. N. Leonard, G. E. Price, K. N. Brown, and A. Meyer-manlapat, TLR3-specific double-stranded RNA oligonucleotide adjuvants induce dendritic cell cross-presentation, CTL responses, and antiviral protection, J Immunol, vol.186, pp.2422-2429, 2011.

I. K. Pang and A. Iwasaki, Inflammasomes as mediators of immunity against influenza virus, Trends Immunol, vol.32, pp.34-41, 2011.

L. Delamarre, M. Pack, H. Chang, I. Mellman, and E. S. Trombetta, Differential lysosomal proteolysis in antigen-presenting cells determines antigen fate, Science, vol.307, pp.1630-1634, 2005.

E. S. Trombetta, M. Ebersold, W. Garrett, M. Pypaert, and I. Mellman, Activation of lysosomal function during dendritic cell maturation, Science, vol.299, pp.1400-1403, 2003.

Y. M. Kim, M. M. Brinkmann, M. E. Paquet, and H. L. Ploegh, UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes, Nature, vol.452, pp.234-238, 2008.

J. C. Roach, G. Glusman, L. Rowen, A. Kaur, and M. K. Purcell, The evolution of vertebrate Toll-like receptors, Proc Natl Acad Sci U S A, vol.102, pp.9577-9582, 2005.

F. J. Barrat and R. L. Coffman, Development of TLR inhibitors for the treatment of autoimmune diseases, Immunol rev, vol.223, pp.271-283, 2008.

M. Matrosovich, T. Matrosovich, W. Garten, and H. D. Klenk, New low-viscosity overlay medium for viral plaque assays, Virol J, vol.3, p.63, 2006.

T. May, W. Lindenmaier, D. Wirth, and P. P. Mueller, Application of a reversible immortalization system for the generation of proliferation-controlled cell lines, Cytotechnology, vol.46, pp.69-78, 2004.

E. Raoust, V. Balloy, I. Garcia-verdugo, L. Touqui, and R. Ramphal, Pseudomonas aeruginosa LPS or flagellin are sufficient to activate TLRdependent signaling in murine alveolar macrophages and airway epithelial cells, PloS one, vol.4, p.7259, 2009.

O. Schulz and C. Reis-e-sousa, Cross-presentation of cell-associated antigens by CD8alpha+ dendritic cells is attributable to their ability to internalize dead cells, Immunology, vol.107, pp.183-189, 2002.