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Simultaneous estimation of T1 and the flip angle in hyperpolarized NMR experiments using acquisition at non-regular time intervals

Abstract : In NMR spectroscopy of the liquid state T1 is typically measured using an inversion recovery pulse sequence; but with hyperpolarized spins use is made of a sequence of multiple small radiofrequency (RF) induced nutations, α. Depending on the values of α and τ, the time interval between the pulses, the estimate of T1 can be artifactually smaller than the real value; so without knowing the value of α the estimate of T1 can be incorrect. Thus, we propose a method that involves a series of pulses with timing governed by a geometric sequence (or in general, any mathematically specified non-uniformly spaced sequence). This approach enables the simultaneous estimation of both the intrinsic T1 value and α. The method was successfully applied to obtain T1 = (44.9 ± 0.3) s and α = (4.0 ± 0.2)° (n = 3) for a sample of hyperpolarized 13C-urea in solution, matching with the inversion recovery pulse sequence estimate of T1 = 44 ± 2 s using non-hyperpolarized 13C-urea in solution.
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https://hal.inrae.fr/hal-02645762
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Submitted on : Friday, May 29, 2020 - 2:35:55 AM
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Max Puckeridge, Guilhem Pages, Philip W. Kuchel. Simultaneous estimation of T1 and the flip angle in hyperpolarized NMR experiments using acquisition at non-regular time intervals. Journal of Magnetic Resonance, Elsevier, 2012, 222, pp.68-73. ⟨10.1016/j.jmr.2012.06.006⟩. ⟨hal-02645762⟩

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