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Saccharomyces cerevisiae decreases inflammatory responses induced by F4+ enterotoxigenic Echerichia coli in porcine intestinal epithelial cells

Abstract : Probiotic yeasts may provide protection against intestinal inflammation induced by enteric pathogens. In piglets, infection with F4(+) enterotoxigenic Escherichia coil (ETEC) leads to inflammation, diarrhea and intestinal damage. In this study, we investigated whether the yeast strains Saccharomyces cerevisiae (Sc, strain CNCM I-3856) and S. cerevisiae variety boulardii (Sb, strain CNCMI-3799) decreased the expression of pro-inflammatory cytokines and chemokines in intestinal epithelial IPI-21 cells cultured with F4(+) ETEC. Results showed that viable Sc inhibited the ETEC-induced TNF-alpha gene expression whereas Sb did not. In contrast, killed Sc failed to inhibit the expression of pro-inflammatory genes. This inhibition was dependent on secreted soluble factors. Sc culture supernatant decreased the TNF-alpha, IL-1 CXCL2 and CCL20 ETEC-induced mRNA. Furthermore, Sc culture supernatant filtrated fraction < 10 kDa displayed the same effects excepted for TNF-cx. Thus, our results extended to Sc (strain CNCM I-3856) the inhibitory effects of some probiotic yeast strains onto inflammation. (C) 2011 Elsevier B.V. All rights reserved
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Galliano Zanello, Francois Meurens, Mustapha Berri, Claire Chevaleyre, Sandrina Melo, et al.. Saccharomyces cerevisiae decreases inflammatory responses induced by F4+ enterotoxigenic Echerichia coli in porcine intestinal epithelial cells. Veterinary Immunology and Immunopathology, Elsevier, 2011, 141 (1-2), pp.133-138. ⟨10.1016/j.vetimm.2011.01.018⟩. ⟨hal-02646439⟩

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