Improving the effectiveness of artificial microRNA (amiR)-mediated resistance against <em>Turnip mosaic virus</em> by combining two amiRs or by targeting highly conserved viral genomic regions. - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Accéder directement au contenu
Article Dans Une Revue Journal of Virology Année : 2013

Improving the effectiveness of artificial microRNA (amiR)-mediated resistance against Turnip mosaic virus by combining two amiRs or by targeting highly conserved viral genomic regions.

Fernando Martinez
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Qi-Wen Niu
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Nam-Hai Chua
  • Fonction : Auteur
José-Antonio Daròs
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Santiago F Elena
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Résumé

A drawback of recent antiviral therapies based on the transgenic expression of artificial microRNAs (amiRs) is the ease with which viruses generate escape mutations. Here, we show two alternative strategies for improving the effectiveness of resistance in plants. First, we expressed two amiRs complementary to independent targets in the viral genome, and second, we designed amiRs complementary to highly conserved RNA motifs in the viral genome.

Dates et versions

hal-02646612 , version 1 (29-05-2020)

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Guillaume Lafforgue, Fernando Martinez, Qi-Wen Niu, Nam-Hai Chua, José-Antonio Daròs, et al.. Improving the effectiveness of artificial microRNA (amiR)-mediated resistance against Turnip mosaic virus by combining two amiRs or by targeting highly conserved viral genomic regions.. Journal of Virology, 2013, 87 (14), pp.8254-6. ⟨10.1128/JVI.00914-13⟩. ⟨hal-02646612⟩

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