Seminal Plasma Proteins as Modulators of the Sperm Function and Their Application in Sperm Biotechnologies - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement Access content directly
Journal Articles (Review Article) Reproduction in Domestic Animals Year : 2012

Seminal Plasma Proteins as Modulators of the Sperm Function and Their Application in Sperm Biotechnologies

Ignacio Caballero
Carmen Alminana
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  • PersonId : 1204403
J. Roca
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Abstract

Contents Somatic cell nuclear transfer (SCNT) was first developed in livestock for the purpose of accelerating the widespread use of superior genotypes. Although many problems still exist now after fifteen years of research owing to the limited understanding of genome reprogramming, SCNT has provided a powerful tool to make copies of selected individuals in different species, to study genome pluripotency and differentiation, opening new avenues of research in regenerative medicine and representing the main route for making transgenic livestock. Besides well-established methods to deliver transgenes, recent development in enzymatic engineering to edit the genome provides more precise and reproducible tools to target-specific genomic loci especially for producing knockout animals. The interest in generating transgenic livestock lies in the agricultural and biomedical areas and it is, in most cases, at the stage of research and development, with few exceptions that are making the way into practical applications.

Dates and versions

hal-02649909 , version 1 (29-05-2020)

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Ignacio Caballero, I. Parrilla, Carmen Alminana, D. del Olmo, J. Roca, et al.. Seminal Plasma Proteins as Modulators of the Sperm Function and Their Application in Sperm Biotechnologies. Reproduction in Domestic Animals, 2012, 47 (Suppl.3), pp.12-21. ⟨10.1111/j.1439-0531.2012.02028.x⟩. ⟨hal-02649909⟩

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