C. D. Davis, Use of exfoliated cells from target tissues to predict responses to bioactive food components, Journal of Nutrition, vol.133, issue.6, pp.1769-1772, 2003.

A. Kamra, G. Kessie, and J. H. Chen, Exfoliated colonic epithelial cells: surrogate targets for evaluation of bioactive food components in cancer prevention, Journal of Nutrition, vol.135, issue.11, pp.2719-2722, 2005.

H. Kitazawa, T. Nishihara, and T. Nambu, Intectin, a novel small intestine-specific glycosylphosphatidylinositolanchored protein, accelerates apoptosis of intestinal epithelial cells, Journal of Biological Chemistry, vol.279, issue.41, pp.42867-42874, 2004.

B. Kaeffer, C. Robert, and M. C. Alexandre-gouabau, Recovery of exfoliated cells from the gastrointestinal tract of premature infants: a new tool to perform "noninvasive biopsies?, Pediatric Research, vol.62, issue.5, pp.564-569, 2007.
URL : https://hal.archives-ouvertes.fr/hal-02661436

F. Aoyama, A. Sawaguchi, S. Ide, K. Kitamura, and T. Suganuma, Exfoliation of gastric pit-parietal cells into the gastric lumen associated with a stimulation of isolated rat gastric mucosa in vitro: a morphological study by the application of cryotechniques, Histochemistry and Cell Biology, vol.129, issue.6, pp.785-793, 2008.

R. S. Chapkin, C. Zhao, and I. Ivanov, Noninvasive stool-based detection of infant gastrointestinal development using gene expression profiles from exfoliated epithelial cells, American Journal of Physiology, vol.298, issue.5, pp.582-589, 2010.

S. M. Frisch and H. Francis, Disruption of epithelial cellmatrix interactions induces apoptosis, Journal of Cell Biology, vol.124, issue.4, pp.619-626, 1994.

J. Debnath, K. R. Mills, N. L. Collins, M. J. Reginato, S. K. Muthuswamy et al., The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini, Cell, vol.111, issue.1, pp.29-40, 2002.

C. Fung, R. Lock, S. Gao, E. Salas, and J. Debnath, Induction of autophagy during extracellular matrix detachment promotes cell survival, Molecular Biology of the Cell, vol.19, issue.3, pp.797-806, 2008.

B. Levine and D. J. Klionsky, Development by self-digestion: molecular mechanisms and biological functions of autophagy, Developmental Cell, vol.6, issue.4, pp.463-477, 2004.

P. A. Thompson, F. F. Kadlubar, and S. M. Vena, Exfoliated ductal epithelial cells in human breast milk: a source of target tissue DNA for molecular epidemiologic studies of breast cancer, Cancer Epidemiology Biomarkers and Prevention, vol.7, issue.1, pp.37-42, 1998.

P. Klein, E. Glaser, and L. Grogan, Biomarker assays in nipple aspirate fluid, Breast Journal, vol.7, issue.6, pp.378-387, 2001.

L. A. Davidson, J. R. Lupton, E. Miskovsky, A. P. Fields, and R. S. Chapkin, Quantification of human intestinal gene expression profiles using exfoliated colonocytes: a pilot study, Biomarkers, vol.8, issue.1, pp.51-61, 2003.

B. Kaeffer, Mammalian intestinal epithelial cells in primary culture: a mini-review, In Vitro Cellular and Developmental Biology, vol.38, issue.3, pp.123-134, 2002.
URL : https://hal.archives-ouvertes.fr/hal-02670321

E. M. Van-lieshout, W. Van-doesburg, R. Van-der, and . Meer, Real-time PCR of host DNA in feces to study differential exfoliation of colonocytes between rats and humans, Scandinavian Journal of Gastroenterology, vol.39, issue.9, pp.852-857, 2004.

R. Lock and J. Debnath, Extracellular matrix regulation of autophagy, Current Opinion in Cell Biology, vol.20, issue.5, pp.583-588, 2008.

S. M. Karam, Lineage commitment and maturation of epithelial cells in the gut, Frontiers in Bioscience, vol.4, pp.286-298, 1999.

C. S. Potten and M. Loeffler, Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt, Development, vol.110, issue.4, pp.1001-1020, 1990.

J. M. Qiu, S. A. Roberts, and C. S. Potten, Cell migration in the small and large bowel shows a strong circadian rhythm, Epithelial Cell Biology, vol.3, issue.4, pp.137-148, 1994.

K. N. Buchi, J. G. Moore, W. J. Hrushesky, R. B. Sothern, and N. H. Rubin, Circadian rhythm of cellular proliferation 8 Journal of Biomedicine and Biotechnology in the human rectal mucosa, Gastroenterology, vol.101, issue.2, pp.410-415, 1991.

G. Marra, M. Anti, and A. Percesepe, Circadian variations of epithelial cell proliferation in human rectal crypts, Gastroenterology, vol.106, issue.4, pp.982-987, 1994.

R. Iwakiri, Y. Gotoh, and T. Noda, Programmed cell death in rat intestine: effect of feeding and fasting, Scandinavian Journal of Gastroenterology, vol.36, issue.1, pp.39-47, 2001.

T. Matsuo, S. Yamaguchi, S. Mitsui, A. Emi, F. Shimoda et al., Control mechanism of the circadian clock for timing of cell division in vivo, Science, vol.302, issue.5643, pp.255-259, 2003.

L. Polidarová, M. Soták, M. Sládek, J. Pácha, and A. Sumová, Temporal gradient in the clock gene and cell-cycle checkpoint kinase wee1 expression along the gut, Chronobiology International, vol.26, issue.4, pp.607-620, 2009.

E. Haus, D. J. Lakatua, L. Sackett-lundeen, and M. White, Circannual variation of intestinal cell proliferation in BDF1 male mice on three lighting regimens, Chronobiology International, vol.1, issue.3, pp.185-194, 1984.

J. R. Gomes, A. A. Pereira, and L. Barth, Circadian variation of the cell proliferation in the jejunal epithelium of rats at weaning phase, Cell Proliferation, vol.38, issue.3, pp.147-152, 2005.

N. Holland, P. Harmatz, and D. Golden, Cytogenetic damage in blood lymphocytes and exfoliated epithelial cells of children with inflammatory bowel disease, Pediatric Research, vol.61, issue.2, pp.209-214, 2007.

M. Steinau, D. R. Lee, M. S. Rajeevan, S. D. Vernon, M. T. Ruffin et al., Gene expression profile of cervical tissue compared to exfoliated cells: impact on biomarker discovery, BMC Genomics, vol.1, 2005.

A. Loktionov, Cell exfoliation in the human colon: myth, reality and implications for colorectal cancer screening, International Journal of Cancer, vol.120, issue.11, pp.2281-2289, 2007.

H. F. Stich, W. Stich, M. P. Rosin, and M. O. Vallejera, Use of the micronucleus test to monitor the effect of vitamin A, betacarotene and canthaxanthin on the buccal mucosa of betel nut/tobacco chewers, International Journal of Cancer, vol.34, issue.6, pp.745-750, 1984.

N. Munoz, M. Hayashi, L. J. Bang, J. Wahrendorf, M. Crespi et al., Effects of riboflavin, retinol, and zinc on micronuclei of buccal mucosa and of esophagus: a randomized double-blind intervention study in China, Journal of the National Cancer Institute, vol.79, issue.4, pp.687-691, 1987.

J. S. Felix and J. W. Littlefield, Human newborn urine as a source of epithelial cells, Birth Defects, vol.16, issue.2, pp.231-237, 1980.

N. Robine, J. P. Relier, and S. L. Bars, Urocytogram, an index of maturity in premature infants, Biology of the Neonate, vol.54, issue.2, pp.93-99, 1988.

W. D. Mojica, A. V. Rapkiewicz, L. A. Liotta, and V. Espina, Manual exfoliation of fresh tissue obviates the need for frozen sections for molecular profiling, Cancer, vol.105, issue.6, pp.483-491, 2005.

W. D. Mojica, L. Stein, and L. Hawthorn, An exfoliation and enrichment strategy results in improved transcriptional profiles when compared to matched formalin fixed samples, BMC Clinical Pathology, vol.7, issue.7, 2007.

A. Loktionov, T. Bandatelova, A. Llewelyn, C. Ferrett, R. C. Lywood et al., Colorectal cell sampling device, World Intellectual Property Organisation. International Publication Number WO, vol.003447, p.1, 2006.

W. Martinet, G. R. Meyer, L. Andries, A. G. Herman, and M. M. Kockx, Detection of autophagy in tissue by standard immunohistochemistry: possibilities and limitations, Autophagy, vol.2, issue.1, pp.55-57, 2006.

S. Chiou, N. Hoa, and A. Hodges, Sulindac sulfide induces autophagic death in gastric epithelial cells via Survivin downregulation: a mechanism of NSAIDs-induced gastric injury, Biochemical Pharmacology, vol.81, issue.11, pp.1317-1323, 2011.

J. Kim, M. Kundu, B. Viollet, and K. L. Guan, AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1, Nature Cell Biology, vol.13, issue.2, pp.132-141, 2011.

H. Roca, Z. S. Varsos, K. Mizutani, and K. J. Pienta, CCL2, survivin and autophagy: new links with implications in human cancer, vol.4, pp.969-971, 2008.

S. Fukuda and L. M. Pelus, Survivin, a cancer target with an emerging role in normal adult tissues, Molecular Cancer Therapeutics, vol.5, issue.5, pp.1087-1098, 2006.

D. C. Altieri, New wirings in the survivin networks, Oncogene, vol.27, issue.48, pp.6276-6284, 2008.

B. Kaeffer, H. Qi, and R. J. Matos, Exfoliated epithelial cells, a source of information on clock genes expression by preterm infants to explore the onset of metabolic syndrome, Proceedings of the 11th Congress of the European Biological Rhythms Society, 2009.

B. Kaeffer and J. Rozé, Procédé d'évaluation in vitro de l'état physiologique d'une muqueuse gastrique et kit pour réaliser une telleévaluation, 2010.

A. Kuma, M. Hatano, and M. Matsui, The role of autophagy during the early neonatal starvation period, Nature, vol.432, issue.7020, pp.1032-1036, 2004.

O. B. Kotoulas, S. A. Kalamidas, and D. J. Kondomerkos, Glycogen autophagy in glucose homeostasis, Pathology Research and Practice, vol.202, issue.9, pp.631-638, 2006.

W. Bursch, A. Karwan, and M. Mayer, Cell death and autophagy: cytokines, drugs, and nutritional factors, Toxicology, vol.254, issue.3, pp.147-157, 2008.

T. Bandaletova, N. Bailey, S. A. Bingham, and A. Loktionov, Isolation of exfoliated colonocytes from human stool as a new technique for colonic cytology, APMIS, vol.110, issue.3, pp.239-246, 2002.

G. Moldenhauer, F. Momburg, P. Moller, R. Schwartz, and G. J. Hammerling, Epithelium-specific surface glycoprotein of M(r) 34,000 is a widely distributed human carcinoma marker, British Journal of Cancer, vol.56, issue.6, pp.714-721, 1987.

K. Sheibani, S. S. Shin, J. Kezirian, and L. M. Weiss, Ber-EP4 antibody as a discriminant in the differential diagnosis of malignant mesothelioma versus adenocarcinoma, American Journal of Surgical Pathology, vol.15, issue.8, pp.779-784, 1991.

B. Kaeffer and L. Pardini, Clock genes of mammalian cells: practical implications in tissue culture, In Vitro Cellular and Developmental Biology, vol.41, issue.10, pp.311-320, 2005.
URL : https://hal.archives-ouvertes.fr/hal-02677655

N. K. Osborn and D. A. Ahlquist, Stool screening for colorectal cancer: molecular approaches, Gastroenterology, vol.128, issue.1, pp.192-206, 2005.

G. P. Albaugh, V. Iyengar, A. Lohani, M. Malayeri, S. Bala et al., Isolation of exfoliated colonic epithelial cells, a novel, non-invasive approach to the study of cellular markers, International Journal of Cancer, vol.52, issue.3, pp.347-350, 1992.

A. P. Gilemore, Anoikis, Journal of Biomedicine and Biotechnology, vol.12, pp.1473-1477, 2005.

S. R. Yan, R. R. Joseph, and K. Rosen, Activation of NF-?B following detachment delays apoptosis in intestinal epithelial cells, Oncogene, vol.24, issue.43, pp.6482-6491, 2005.

Z. Liu, H. Li, and X. Wu, Detachment-induced upregulation of XIAP and cIAP2 delays anoikis of intestinal epithelial cells, Oncogene, vol.25, issue.59, pp.7680-7690, 2006.

D. J. Klionsky, Autophagy, Current Biology, vol.15, issue.8, pp.282-283, 2005.
URL : https://hal.archives-ouvertes.fr/hal-02373917

A. C. Massey, S. Kaushik, and A. M. Cuervo, Lysosomal chat maintains the balance, Autophagy, vol.2, issue.4, pp.325-327, 2006.

F. Cecconi and B. Levine, The role of autophagy in mammalian development: cell makeover rather than cell death, Developmental Cell, vol.15, issue.3, pp.344-357, 2008.

E. F. Blommaart, J. J. Luiken, P. J. Blommaart, G. M. Van-woerkom, and A. J. Meijer, Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes, Journal of Biological Chemistry, vol.270, issue.5, pp.2320-2326, 1995.

A. Chen, The circadian rhythm of expression of Bmal1 and Cry1 in peripheral blood mononuclear cells of preterm neonates, Journal of Maternal-Fetal and Neonatal Medicine, vol.23, issue.10, pp.1172-1175, 2010.

M. Hausmann, K. Leucht, and C. Ploner, BCL-2 modifying factor (BMF) is a central regulator of anoikis in human intestinal epithelial cells, Journal of Biological Chemistry, vol.286, issue.30, pp.26533-26540, 2011.

M. M. Godlewski, N. Hallay, J. B. Bier?a, and R. Zabielski, Molecular mechanism of programmed cell death in the gut epithelium of neonatal piglets, Journal of Physiology and Pharmacology, vol.58, issue.3, pp.97-113, 2007.

P. Nair, S. Lagerholm, and S. Dutta, Coprocytobiology: on the nature of cellular elements from stools in the pathophysiology of colonic disease, Journal of Clinical Gastroenterology, vol.36, issue.5, pp.84-93, 2003.

D. S. Chandel, G. T. Braileanu, J. J. Chen, H. H. Chen, and P. Panigrahi, Live colonocytes in newborn stool: surrogates for evaluation of gut physiology and disease pathogenesis, Pediatric Research, vol.70, issue.2, pp.153-158, 2011.

S. C. Kalhan and J. M. Edmison, Effect of intravenous amino acids on protein kinetics in preterm infants, Current Opinion in Clinical Nutrition and Metabolic Care, vol.10, issue.1, pp.69-74, 2007.

U. M. Sachdeva and C. B. Thompson, Diurnal rhythms of autophagy, Autophagy, vol.4, issue.5, pp.581-589, 2008.

M. Gallego and D. M. Virshup, Post-translational modifications regulate the ticking of the circadian clock, Nature Reviews Molecular Cell Biology, vol.8, issue.2, pp.139-148, 2007.

R. A. Waterland and K. B. Michels, Epigenetic epidemiology of the developmental origins hypothesis, Annual Review of Nutrition, vol.27, pp.363-388, 2007.

T. Alenghat, K. Meyers, and S. E. Mullican, Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology, Nature, vol.456, issue.7224, pp.997-1000, 2008.

K. Yagita, F. Tamanini, G. T. Van-der, H. Horst, and . Okamura, Molecular mechanisms of the biological clock in cultured fibroblasts, Science, vol.292, issue.5515, pp.278-281, 2001.

M. Reick, J. A. Garcia, C. Dudley, and S. L. Mcknight, NPAS2: an analog of clock operative in the mammalian forebrain, Science, vol.293, issue.5529, pp.506-509, 2001.

J. Rutter, M. Reick, L. C. Wu, and S. L. Mcknight, Regulation of crock and NPAS2 DNA binding by the redox state of NAD cofactors, Science, vol.293, issue.5529, pp.510-514, 2001.

B. Gan, Y. Yoo, and J. L. Guan, Association of focal adhesion kinase with tuberous sclerosis complex 2 in the regulation of S6 kinase activation and cell growth, Journal of Biological Chemistry, vol.281, issue.49, pp.37321-37329, 2006.

K. A. Stokkan, S. Yamazaki, H. Tei, Y. Sakaki, and M. Menaker, Entrainment of the circadian clock in the liver by feeding, Science, vol.291, issue.5503, pp.490-493, 2001.

E. Nagoshi, C. Saini, C. Bauer, T. Laroche, F. Naef et al., Circadian gene expression in individual fibroblasts: cell-autonomous and self-sustained oscillators pass time to daughter cells, Cell, vol.119, issue.5, pp.693-705, 2004.

S. A. Brown, F. Fleury-olela, and E. Nagoshi, The period length of fibroblast circadian gene expression varies widely among human individuals, PLoS Biology, vol.3, issue.10, p.6, 2005.

N. Mizushima, A. Yamamoto, M. Matsui, T. Yoshimori, and Y. Ohsumi, In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker, Molecular Biology of the Cell, vol.15, issue.3, pp.1101-1111, 2004.

R. Orozco-sólis, R. J. Matos, and S. Lopes-de, Perinatal nutrient restriction induces long-lasting alterations in the circadian expression pattern of genes regulating food intake and energy metabolism, International Journal of Obesity, vol.35, pp.990-1000, 2011.

A. Loboda, B. Fine, and J. Joseph, Diurnal variation of the human adipose transcriptome and the link to metabolic disease, BMC Medical Genomics, vol.2, issue.7, 2009.

A. Sumová, Z. Bendová, and M. Sládek, Setting the biological time in central and peripheral clocks during ontogenesis, FEBS Letters, vol.580, issue.12, pp.2836-2842, 2006.

H. Guo, J. M. Brewer, M. N. Lehman, and E. L. Bittman, Suprachiasmatic regulation of circadian rhythms of gene expression in hamster peripheral organs: effects of transplanting the pacemaker, Journal of Neuroscience, vol.26, issue.24, pp.6406-6412, 2006.