Cell-derived vesicles as a bioplatform for the encapsulation of theranostic nanomaterials - INRAE - Institut national de recherche pour l’agriculture, l’alimentation et l’environnement
Journal Articles Nanoscale Year : 2013

Cell-derived vesicles as a bioplatform for the encapsulation of theranostic nanomaterials

Abstract

There is a great deal of interest in the development of nanoplatforms gathering versatility and multifunctionality. The strategy reported herein meets these requirements and further integrates a cell-friendly shell in a bio-inspired approach. By taking advantage of a cell mechanism of biomolecule transport using vesicles, we engineered a hybrid biogenic nanoplatform able to encapsulate a set of nanoparticles regardless of their chemistry or shape. As a proof of versatility, different types of hybrid nanovesicles were produced: magnetic, magnetic-metallic and magnetic-fluorescent vesicles, either a single component or multiple components, combining the advantageous properties of each integrant nanoparticle. These nanoparticle-loaded vesicles can be manipulated, monitored by MRI and/or fluorescence imaging methods, while acting as efficient nano-heaters. The resulting assets for targeting, imaging and therapy converge for the outline of a new generation of nanosystems merging versatility and multifunctionality into a bio-camouflaged and bio-inspired approach.
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Dates and versions

hal-02650561 , version 1 (29-05-2020)

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Amanda K. Andriola Silva, Riccardo Di Corato, Teresa Pellegrino, Sophie S. Chat, Giammarino Pugliese, et al.. Cell-derived vesicles as a bioplatform for the encapsulation of theranostic nanomaterials. Nanoscale, 2013, 5 (23), pp.11374-11384. ⟨10.1039/c3nr01541f⟩. ⟨hal-02650561⟩
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