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Lack of Effect of Propranolol in the Treatment of Lymphangioma in Two Children

Abstract : Vascular lesions such as hemangiomas and lymphangiomas can cause significant mortality and morbidity, as well as amblyopia when located in the orbit. Oral propranolol can regress infantile hemangioma during infancy and up to 23months of age, but its effect on lymphangioma has not been demonstrated. We present two cases of lymphatic malformations treated with oral propranolol. Patient 1 is a 2-year-old boy with macrocystic bilateral cervical lymphangioma extending to the pharynx and larynx and microcystic lymphangioma of the tongue. The patient was started on propranolol 2mg/kg/day starting at 17months of age, and after 3months only a very slight decrease in tongue volume was noted. Patient 2 is a 3.5-year-old boy with magnetic resonance imaging evidence of right facial complex lymphangioma with venous malformation. The patient was placed on oral propranolol 2mg/kg/day. After 3months of treatment, no change in the lesion was noted except for a transient decrease in the size of the conjunctival telangiectasia. Propranolol 2mg/kg/day was not effective in treating lymphatic malformations in two children, both older than 17months at the time of treatment.
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https://hal.inrae.fr/hal-02652414
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Submitted on : Friday, May 29, 2020 - 7:12:15 PM
Last modification on : Thursday, May 6, 2021 - 2:22:43 PM

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Annabel Maruani, Shanna Brown, Gérard Lorette, Soizick Pondaven-Letourmy, Denis Herbreteau, et al.. Lack of Effect of Propranolol in the Treatment of Lymphangioma in Two Children. Pediatric Dermatology, Wiley, 2013, 30 (3), pp.383 - 385. ⟨10.1111/j.1525-1470.2012.01864.x⟩. ⟨hal-02652414⟩

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