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Journal articles

Réponses antivirales des poissons : de l'interféron aux lymphocytes T

Abstract : Viruses affecting farmed fish species, such as the rainbow trout, have been studied extensively because they cause significant economic losses. Studies on vaccines developed against Viral Hemorrhagic Septicemia (VHS) have provided evidence of an effective and specific response based on neutralizing antibodies, as well as of an immune memory. Various techniques of differential transcript analysis were used to investigate the non-specific leukocyte response to the VHS virus in trout. As in mammals, this response was dependent on interferon-responsive genes. A VDJ junction spectratyping approach of transcripts of the specific T-cell antigen receptor (TCR) was also developed to examine the specific cellular response in rainbow trout. This approach was used to show the existence of complex antiviral T-cell responses in fish.
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Journal articles
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https://hal.inrae.fr/hal-02653970
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Submitted on : Friday, May 29, 2020 - 9:19:39 PM
Last modification on : Tuesday, April 5, 2022 - 11:38:02 AM

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  • HAL Id : hal-02653970, version 1
  • PRODINRA : 147997

Citation

Pierre Boudinot, Abdenour Benmansour. Réponses antivirales des poissons : de l'interféron aux lymphocytes T. Bulletin de l'Académie Vétérinaire de France, Académie vétérinaire de France, 2007, 160 (1), pp.39-44. ⟨hal-02653970⟩

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