, DHA: docosahexaenoic acid, vol.20, pp.1-9

. P/s, polyunsaturated fatty acid/saturated fatty acid ratio; PUFA: polyunsaturated fatty acid; SA: stearic acid, 18:0; SFA: saturated fatty acid

H. Palsdottir and C. Hunte, Lipids in membrane protein structures, Biochim Biophys Acta, vol.1666, pp.2-18, 2004.

S. K. Gebauer, T. L. Psota, and W. S. Harris, Kris-Etherton PM: n-3 fatty acid dietary recommendations and food sources to achieve essentiality and cardiovascular benefits, Am J Clin Nutr, vol.83, pp.1526-1535, 2006.

D. J. Holub and B. J. Holub, Omega-3 fatty acids from fish oils and cardiovascular disease, Mol Cell Biochem, vol.263, pp.217-225, 2004.

C. Wang, W. S. Harris, M. Chung, A. H. Lichtenstein, E. M. Balk et al., n-3 Fatty acids from fish or fish-oil supplements, but not alpha-linolenic acid, benefit cardiovascular disease outcomes in primary-and secondary-prevention studies: a systematic review, Am J Clin Nutr, vol.84, pp.5-17, 2006.

G. L. Russo, Dietary n-6 and n-3 polyunsaturated fatty acids: From biochemistry to clinical implications in cardiovascular prevention, Biochem Pharmacol, 2008.

G. C. Burdge, Metabolism of alpha-linolenic acid in humans, Prostaglandins Leukot Essent Fatty Acids, vol.75, pp.161-168, 2006.

M. Plourde and S. C. Cunnane, Extremely limited synthesis of long chain polyunsaturates in adults: implications for their dietary essentiality and use as supplements, Appl Physiol Nutr Metab, vol.32, pp.619-634, 2007.

A. Ayalew-pervanchon, D. Rousseau, D. Moreau, P. Assayag, P. Weill et al., Long-term effect of dietary {alpha}-linolenic acid or decosahexaenoic acid on incorporation of decosahexaenoic acid in membranes and its influence on rat heart in vivo, Am J Physiol Heart Circ Physiol, vol.293, pp.2296-2304, 2007.

M. Igarashi, J. C. Demar, K. Ma, L. Chang, J. M. Bell et al., Upregulated liver conversion of alpha-linolenic acid to docosahexaenoic acid in rats on a 15 week n-3 PUFA-deficient diet, J Lipid Res, vol.48, pp.152-164, 2007.

Q. S. Tahin, M. Blum, and E. Carafoli, The fatty acid composition of subcellular membranes of rat liver, heart, and brain: dietinduced modifications, Eur J Biochem, vol.121, pp.5-13, 1981.

M. V. Robbez, A. Lucas, A. M. Gueugneau, J. P. Macaire, J. L. Paul et al., Long-chain (n-3) polyunsaturated fatty acids prevent metabolic and vascular disorders in fructose-fed rats, J Nutr, vol.138, pp.1915-1922, 2008.
URL : https://hal.archives-ouvertes.fr/hal-02657613

A. Grynberg, A. Fournier, J. P. Sergiel, and P. Athias, Membrane docosahexaenoic acid vs. eicosapentaenoic acid and the beating function of the cardiomyocyte and its regulation through the adrenergic receptors, Lipids, vol.31, pp.205-210, 1996.
URL : https://hal.archives-ouvertes.fr/hal-02691779

D. Rousseau, C. Héliès-toussaint, D. Moreau, D. Raederstorff, and A. Grynberg, Dietary n-3 PUFAs affect the blood pressure rise and cardiac impairments in a hyperinsulinemia rat model in vivo, Am J Physiol Heart Circ Physiol, vol.285, pp.1294-1302, 2003.
URL : https://hal.archives-ouvertes.fr/hal-02676983

J. Dallongeville, J. Yarnell, P. Ducimetiere, D. Arveiler, J. Ferrieres et al., Amouyel P: Fish consumption is associated with lower heart rates, Circulation, vol.108, pp.820-825, 2003.

J. A. Austria, M. N. Richard, M. N. Chahine, A. L. Edel, L. J. Malcolmson et al., Bioavailability of alpha-linolenic acid in subjects after ingestion of three different forms of flaxseed, J Am Coll Nutr, vol.27, pp.214-221, 2008.

S. Paris, M. Fosset, D. Samuel, and G. Ailhaud, Chick embryo plasma membrane from cardiac muscle and cultured heart cells: isolation procedure and absence of fatty acid-activating enzymes, J Mol Cell Cardiol, vol.9, pp.161-174, 1977.

A. Lombet and M. Lazdunski, Characterization, solubilization, affinity labeling and purification of the cardiac Na+ channel using Tityus toxin gamma, Eur J Biochem, vol.141, pp.651-660, 1984.

J. Folch, M. Lees, S. Stanley, and G. H. , A simple method for the isolation and purification of total lipides from animal tissues, J Biol Chem, vol.226, pp.497-509, 1957.

W. R. Morrison and L. M. Smith, Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoridemethanol, J Lipid Res, vol.5, pp.600-608, 1964.

Y. F. Xiao, D. C. Sigg, and A. Leaf, The antiarrhythmic effect of n-3 polyunsaturated fatty acids: modulation of cardiac ion channels as a potential mechanism, J Membr Biol, vol.206, pp.141-154, 2005.

W. R. Leifert, C. L. Dorian, A. Jahangiri, and E. J. Mcmurchie, Dietary fish oil prevents asynchronous contractility and alters Ca(2+) handling in adult rat cardiomyocytes, J Nutr Biochem, vol.12, pp.365-376, 2001.

K. K. Cheema, M. R. Dent, H. K. Saini, N. Aroutiounova, and P. S. Tappia, Prenatal exposure to maternal undernutrition induces adult cardiac dysfunction, Br J Nutr, vol.93, pp.471-477, 2005.

P. L. Mclennan, M. Y. Abeywardena, and J. S. Charnock, The influence of age and dietary fat in an animal model of sudden cardiac death, Aust N Z J Med, vol.19, pp.1-5, 1989.

A. J. Owen, B. A. Peter-przyborowska, A. J. Hoy, and P. L. Mclennan, Dietary fish oil dose-and time-response effects on cardiac phospholipid fatty acid composition, Lipids, vol.39, pp.955-961, 2004.

D. Rousseau, C. Helies-toussaint, D. Raederstorff, D. Moreau, and A. Grynberg, Dietary n-3 polyunsaturated fatty acids affect the development of renovascular hypertension in rats, Mol Cell Biochem, vol.225, pp.109-119, 2001.
URL : https://hal.archives-ouvertes.fr/hal-02681463

Y. H. Lin and N. Salem, Whole body distribution of deuterated linoleic and alpha-linolenic acids and their metabolites in the rat, J Lipid Res, vol.48, pp.2709-2724, 2007.

S. C. Cunnane, M. A. Ryan, C. R. Nadeau, R. P. Bazinet, K. Musa-veloso et al., Why is carbon from some polyunsaturates extensively recycled into lipid synthesis?, Lipids, vol.38, pp.477-484, 2003.

M. Igarashi, K. Ma, L. Chang, J. M. Bell, and S. I. Rapoport, Rat heart cannot synthesize docosahexaenoic acid from circulating alpha-linolenic acid because it lacks elongase-2, J Lipid Res, vol.49, pp.1735-1745, 2008.

S. Liautaud, A. Grynberg, J. Mourot, and P. Athias, Fatty acids of hearts from rats fed linseed or sunflower oil and of cultured cardiomyocytes grown on their sera, Cardioscience, vol.2, pp.55-61, 1991.

H. Sprecher, Metabolism of highly unsaturated n-3 and n-6 fatty acids, Biochim Biophys Acta, vol.1486, pp.219-231, 2000.

J. T. Goldstein, A. Dobrzyn, M. Clagett-dame, J. W. Pike, and H. F. Deluca, Isolation and characterization of unsaturated fatty acids as natural ligands for the retinoid-X receptor, Arch Biochem Biophys, vol.420, pp.185-193, 2003.

A. Chawla, J. J. Repa, R. M. Evans, and D. J. Mangelsdorf, Nuclear receptors and lipid physiology: opening the X-files, Science, vol.294, pp.1866-1870, 2001.

S. Pepe, Effect of dietary polyunsaturated fatty acids on agerelated changes in cardiac mitochondrial membranes, Exp Gerontol, vol.40, pp.751-758, 2005.

S. Ovide-bordeaux and A. Grynberg, Docosahexaenoic acid affects insulin deficiency-and insulin resistance-induced alterations in cardiac mitochondria, Am J Physiol Regul Integr Comp Physiol, vol.286, pp.519-527, 2004.

Y. J. Jiang, B. Lu, F. Y. Xu, J. Gartshore, W. A. Taylor et al., Stimulation of cardiac cardiolipin biosynthesis by PPARalpha activation, J Lipid Res, vol.45, pp.244-252, 2004.

R. Pamplona, M. Portero-otin, A. Sanz, J. Requena, and G. Barja, Modification of the longevity-related degree of fatty acid unsaturation modulates oxidative damage to proteins and mitochondrial DNA in liver and brain, Exp Gerontol, vol.39, pp.725-733, 2004.

A. Grynberg, A. Fournier, J. P. Sergiel, and P. Athias, Effect of docosahexaenoic acid and eicosapentaenoic acid in the phospholipids of rat heart muscle cells on adrenoceptor responsiveness and mechanism, J Mol Cell Cardiol, vol.27, pp.2507-2520, 1995.

B. Rinaldi, D. Pierro, P. Vitelli, M. R. , D. 'amico et al., Effects of docosahexaenoic acid on calcium pathway in adult rat cardiomyocytes, vol.71, pp.993-1004, 2002.

S. Williams, J. T. Meij, and V. Panagia, Membrane phospholipids and adrenergic receptor function, Mol Cell Biochem, pp.217-221, 1995.

B. Ponsard, I. Durot, P. Delerive, F. Oudot, C. Cordelet et al., Cross-influence of membrane polyunsaturated fatty acids and hypoxia-reoxygenation on alpha-and beta-adrenergic function of rat cardiomyocytes, Lipids, vol.34, pp.457-466, 1999.

R. A. Siddiqui, K. A. Harvey, and G. P. Zaloga, Modulation of enzymatic activities by n-3 polyunsaturated fatty acids to support cardiovascular health, J Nutr Biochem, vol.19, pp.417-437, 2008.

S. Pepe, Dietary polyunsaturated fatty acids and age-related membrane changes in the heart, Ann N Y Acad Sci, vol.1114, pp.381-388, 2007.

S. R. Wassall and W. Stillwell, Docosahexaenoic acid domains: the ultimate non-raft membrane domain, Chem Phys Lipids, vol.153, pp.57-63, 2008.