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 Novel aspects of COP9 signalosome functions revealed through analysis of hypomorphic csn mutants. Johannes Stuttmann 9f46567d54d493bfdb42092d540e146f genetik.uni-halle.de johannes-stuttmann 1194366 1615609-1194366 https://orcid.org/0000-0002-6207-094X https://www.idref.fr/139593454 emRc1xsAAAAJ Jane E Parker 569582-0 Laurent Noel f45662db49a1090f1bc2144e58bea8a0 inrae.fr laurent-noel 738400 677465-738400 https://orcid.org/0000-0002-0110-1423 Migration ProdInra 9e5ed7d56b52b3d4383123b1ffb42236 inrae.fr 2020-05-30 00:15:57 2025-10-22 18:04:08 2020-05-30 00:15:57 2009 Scientists contributor Migration ProdInra 9e5ed7d56b52b3d4383123b1ffb42236 inrae.fr CCSD hal-02656883 https://hal.inrae.fr/hal-02656883 stuttmann:hal-02656883 <i>Plant Signaling and Behavior</i>, 2009, 4 (9), pp.896-8 Plant Signaling and Behavior, 2009, 4 (9), pp.896-8 Université de Toulouse CNRS - Centre national de la recherche scientifique INRA - Institut national de la recherche agronomique Archive ouverte en agrobiosciences Institut National de Recherche en Agriculture, Alimentation et Environnement Université Toulouse 3 Université de Toulouse / Toulouse INP Université de Toulouse / Toulouse INP International No Yes Novel aspects of COP9 signalosome functions revealed through analysis of hypomorphic csn mutants. Johannes Stuttmann 9f46567d54d493bfdb42092d540e146f genetik.uni-halle.de johannes-stuttmann 1194366 1615609-1194366 https://orcid.org/0000-0002-6207-094X https://www.idref.fr/139593454 emRc1xsAAAAJ Jane E Parker 569582-0 Laurent Noel f45662db49a1090f1bc2144e58bea8a0 inrae.fr laurent-noel 738400 677465-738400 https://orcid.org/0000-0002-0110-1423 35537 1559-2316 1559-2324 Plant Signaling and Behavior Taylor & Francis 4 9 896-8 2009 262276 19847120 English Life Sciences [q-bio] Life Sciences [q-bio]/Vegetal Biology Journal articles Journal articles Journal articles

The COP9 signalosome (CSN) is a conserved eukaryotic protein complex implicated in the regulation of cullin-RING type E3 ubiquitin ligases by cleaving the small peptide RUB/Nedd8 from cullins. However, detailed analysis of CSN physiological functions in Arabidopsis has been hampered by the early seedling-lethality of csn null mutants. We and others have now identified a number of viable hypomorphic csn mutants which start to reveal novel CSN-dependent activities in adult Arabidopsis plants. Here, we present a detailed comparative analysis of the csn5a-1 and csn2-5 mutants as a mean to improve understanding of CSN functions in plant cells. Our observations point to CSN-independent activities of CSN5 and suggest a role of the CSN in cytoskeleton assembly/organization.

 Unité mixte de recherche interactions plantes-microorganismes 1999-01-01 2014-12-31
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https://ror.org/01x3gbx83 Institut National de la Recherche Agronomique INRA 1946-05-18 2019-12-31
http://www.inra.fr 026404672 0000000121617331 https://ror.org/02v6kpv12 Q1273188 Université Toulouse III - Paul Sabatier UT3 2025-01-01
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https://www.univ-toulouse.fr/ 02636817X 0000000122597504 https://ror.org/02feahw73 Centre National de la Recherche Scientifique CNRS 1939-10-19
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